Team:UESTC-China/Hardware

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Overview

In order to combine the project and the progress of the experiment, we designed the community drug recycling bin and the fluorescence detection device in the hardware part.

The community drug recycling bin is used to collect and recycle expired drugs. The initial modular design allows for the recovery of three types of drugs, and the design and implementation of the detection and processing module for ciprofloxacin. Figure 1 and animation show the design and theoretical ideas of a special CIP detection module.

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Fig. 1. Expired drugs recycling and degrading device, which we call it Drug Avenger

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Fig. 2. Print of the Drug Avenger

The fluorescence detection device is used to specifically detect the CIP concentration, and is assembled by a switching power supply, water pumps, capture card, photodetector, and an external device.
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Fig. 3. The fluorescence detection device

Device iteration

In the development process of hardware, our detection device module has been updated three times, and finally realized the design realization of the third generation version.

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The first generation of detection modules consists of photodetectors, laser sources, STM32 Development board, pumps, filters, lenses, and external devices with an optical path of 90°.
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Fig. 4. Light path of the first generation device

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The first-generation device is not efficient in fluorescence excitation, and the individual details are unreasonable because of the requirements and cost of 3D printing technology. But the second-generation device optimizes the optical path based on the first-generation device and no longer needs transparent parts. It use 45° angle to enhance the acquisition of fluorescent signals.
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Fig. 5. Light path of the second generation device

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Through the communication with a doctor, we made up for the shortcomings of the original device in the fixation of the engineering bacteria, and designed the funnel-shaped groove, which is conducive to the accumulation of engineering bacteria and also improve the stability of the detection fluorescent signal.
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Fig. 6. The funnel-shaped groove of the third generation device

Finally, we designed a community drug recycling bin and fluorescence detection device based on the third generation of detection module devices. For more detailed information on the design of community drug recycling bins and fluorescence detection devices,

please click on the two pictures below.

Expired drugs recycling and degrading device
Fluorescence detection devices
Open source
In order to make other teams purchase them and improve our hardware, we share important parameters, 3D models and acquisition software below.
Parameters
Input Output Size Wavelength Chip Power Aperture Cut-On Wavelength focal length diameter
Photodetector Silicon-based avalanche diode 200~1000nm
Laser 450nm 4.8mw
Development board 12V STM32F103C8T6
Relay 12V Four-way optocoupler isolation
Water pump 5V
Filter membrane 0.22μm
Switching power supply 220V/110V 12V/5V
optical filter 500nm
Convex lens 25mm 1 inch

Expectation

In the future, we intend to improve the usability and extensiveness of our recycling bins by designing other drug degradation modules. We have reserved some modular designs to make them more convenient and easy to implement. We also hope to optimize the design detection module. Our signals are more stable and efficient, enabling the implementation of the device at a lower cost.

Copyright © 2019 iGEM UESTC-China
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