Team:Jiangsu High School

Team Name: Jiangsu_High_School


Abstract:


Alzheimer's disease (AD) is a progressively neurodegenerative disease, characterized by cognitive deficits and personality and behavioral changes. Formation of amyloid plaque and neurofibrillary tangles (NFTs) resulted from the accumulation of β- amyloid and hyperphosphorylation of tau protein,respectively, are key manifestation of AD, which even precedes the Irreversible apoptosis and loss of neurons and synapses. Autophagy is a self-degradative process,plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles. It is worth noting that studies have shown that stimulation of autophagy promotes clearance of Aβ and phosphorylated Tau. In our study, we have established an autophagy agonist screening platform based on autophagic flow detection, and it is expected that compounds with autophagy agonism will be screened from the compound library for the treatment of AD.

Key words:


Alzheimer’ disease; amyloid plaque;neurofibrillary tangles;autophagy;autophagy agonist screening platform.