Team:IIT-Madras/Chassis
MEET F. SOLANI!
F. solani in Literature
Fusarium solani is a species complex of at least 26 closely related filamentous fungi in the division Ascomycota. F. solani is found in soils across the world and as a soil fungus, it is associated with the roots of plants and may be found as deep in the ground as 80 cm. It is frequently isolated in tropic, subtropic, and temperate locations.
Endophytes are a group of microorganisms that spend their entire or a significant fraction of their life cycle within the living tissues of a host plant without causing any visible symptoms. F. solani was originally found as an endophytic fungus in Cyanea acuminata. In the Indian context, the fungus is primarily found as an endophyte in Nothapodytes nimmoniana, a tree that is endemic to the Western Ghats of South India.
F. solani usually produces loose, slimy colonies that are white and cottony, and has aerial hyphae that give rise to conidiophores laterally.
F. solani as a Chassis
Optimum temperature for growth : 27-28°C
F. solani grows rapidly on Potato Dextrose Agar (PDA), and the spores were collected and stored as glycerol stock after a growth period of 7 days. The fungus produced colonies that were white in colour, and occasionally a reddish-pink.
F. solani has most of the biosynthetic machinery to produce camptothecin except strictosidine synthase (STR). N. nimmoniana produces the protein STR and together, their association is responsible for the production of the alkaloid topoisomerase-1 inhibitor CPT.
References
Yamazaki Y, Kitajima M, Arita M, et al. Biosynthesis of camptothecin. In silico and in vivo tracer study from [1-13C]glucose. Plant Physiol. 2004;
Kusari S, Zühlke S, Spiteller M. Effect of artificial reconstitution of the interaction between the plant Camptotheca acuminata and the fungal endophyte Fusarium solani on camptothecin biosynthesis. J Nat Prod. 2011
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Department of Biotechnology, IIT Madras.
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