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iGEM IIT MADRAS: A SIMPLE DESCRIPTION

The main players of our project for 2019 are the fungus Fusarium solani, a plant Nothapodytes nimmoniana and the anti-cancer drug camptothecin. Camptothecin and its analogues are used in the treatment of a number of cancers including ovarian and colon cancers. Nothapodytes nimmoniana is endemic to the Western Ghat region of India and has been overharvested for medicinal purposes. As an alternative, we aim to produce camptothecin using F. solani - our organism of choice for this year’s project.

The pathway for the production of camptothecin in plants is also found in our fungus but it lacks one key component - an important enzyme strictosidine synthase. We aim to engineer our fungus with this enzyme to produce camptothecin.

Team:IIT-Madras/Simple

iGEM IIT MADRAS: A SIMPLE DESCRIPTION