Team:Tianjin
Evolution is an old and continuous topic. Species evolution caused by mutation and natural selection has continued in nature for 4.6 billion years. And the general trend of biological evolution is from low to high, from simple to complex.
After the birth of molecular biology, people began to transform organisms on the molecular level, such as targeted screening using induced changes, or genetic engineering to obtain the desired strains (these transformations are, to some extent, a directed evolution), but the above method is not only small in scale but also time consuming.
Therefore, we hope to achieve rapid evolution through gene-level transfer in chromosomes, so as to build an engineering scheme to achieve the stability of large segments of transfer and the reliability and repeatability of evolution.
Thanks for the voice from Apple Inc.
This includes the background and Inspiration of the project, the specific experimental design, the schedule of the project, and the final experimental results and conclusions.
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In the project, we designed several BioBricks, recorded and characterized their sequence, molecular construction and function in detail. It includes basic parts, composite parts and improved parts.
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We developed a mathematical model to predict the influence of where to insert the centromere and the dynamics of cells affected. By doing so, we expect to estimate the efficiency with OD600 after using our centromere stabilizing element so as to modify our design.
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We creatively integrated the "Reflexivity Principle + Principles of Economics" agreement to collect all kinds of information from outside to guide the design, formulation, implementation and adjustment of our project and assess how the world might affect our work and how our work might affect the world. Abundant education and public engagement activities and effective team cooperation are also the important parts of our work.
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