As a mosquito-borne disease, malaria causes hundreds of thousands of deaths every year. This year NAU-CHINA hopes to block the transmission of malaria by engineering symbiotic bacteria in mosquito's midgut to secret multiple anti-Plasmodium peptides to kill the Plasmodium parasites in their most vulnerable stage.Get Started!
We used two systems, a TEV protease cleavage system and a HasA secretion system, which worked together to guarantee the anti-Plasmodium effect. The symbiotic bacteria Serratia marcescens we chose make our project hopefully work under realistic conditions.Get Started!
Our large amount of experimental data supporting our project was really exciting —— TEVp's cutting efficiency was beyond our expectations, and the success of the secretion system in S. marcescens has made our project practical.
We constructed an expression model to ensure an appropriate ratio of the fusion effector protein and TEVp, and an epidemic model is made to realize our project to control malaria in the natural environment.
MARS: HUMAN PRACTICES
We did lots of work to make sure that our project can be good for the world, since science would be nothing if it is not related to the society.