Team:SMMU-China/Part Collection
1.Synthetic receptors
OverView
Transmembrane receptors can continuously monitor the extracellular milieu, and transduce specific extracellular signals into intracellular responses. Binding of ligands that match the receptors triggers intracellular signaling cascades and ultimately induces transcriptional changes[1]. We found some latest receptors, with some of them sensing and responding to soluble molecules while others sensing and responding to surface-bound molecules. We placed them in our different devices, giving them different roles, and compared their function to determine the most suitable one.
Receptors for surface-bound molecules:
CAR
The best-known examples of synthetic receptors that sense and respond to molecules bound to the surface of other cells are the so-called chimeric antigen receptors (CARs). Based on large number of researches and characterization of CARs, we chose it as the core tool to achieve the killing function of the core device.
Our synthetic receptor CARs contained an extracellular scFv trastuzumab (BBa_K3132022) and an intracellular regulatory domain of the NK-cell receptor complex (BBa_K3132021) (figure 1a). CAR-expressing NK cells can detect tumor cells with HER2 on the surface and attack them.
DEMO PART 2
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DEMO PART 3
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