Team:Shanghai High School/Contribution

The characterization protein and early diagnosis of cervical cancer

Here we demonstrate specific protein expression variations related to NFX1 over-expression, a gene found to be closely associated with cervical cancer.

Contribution

Contribution
In the early 21st century, scientists made great progress on scientific research especially in the medical field: artemisinins are popularized in Africa, the artificial-organ technique is well-developed and new progression on curing lung cancer. As the medicine industries flourishing nowadays, news about unqualified-vaccines are exploded in the peacetime. Why? Because there are many systematic gaps in the preparation of vaccines, many unqualified vaccines have been sent to various medical centers in the country. It is well known that in the case of a deterioration of the vaccine, it is easy to cause side effects or even life-threatening to humans. It's hard to imagine a healthy ordinary person getting sick after vaccination. In this case, who is willing to vaccinate? To eliminate public concerns about vaccines, we have practiced and innovated vaccine temperature testing.
The old temperature indicator label, a label with a heat-sensitive material, reflects the heat damage of the vaccine through its color change. It is also the only temperature indicator that can track the entire time from the exit to the end-user. However, such indicators have the disadvantage that they change color due to the accumulated heat at any temperature. In the case where the optimal injection temperature of the rabies vaccine is about 10 degrees Celsius, the indicator will still change color due to the slight heat at this temperature. It may be that the heat of this smile is not enough to cause an effect, but it is easy to cause significant discoloration of the indicator after the vaccine is stored for a sufficient time like 1, 2 weeks. Because discolored vaccines may be qualified or degraded, it is difficult for medical personnel to identify the quality of the vaccine. Vaccines are a product of high price and value. If these qualified color-changing vaccines are thrown away, it will cause unnecessary medical waste and cause welfare losses. Even some people will simply use a vaccine marked with a color change to give a medical accident.
Fortunately, we have found a new solution. By using heat shock fluorescent proteins, we solved the problem of unnecessary loss due to heat accumulation. Because this protein only opens the RNA single-strand structure at a certain temperature, allowing the protein to change color, which not only ensures that the staff does not have unnecessary difficulty in distinguishing quality due to heat accumulation problems, but also reduces the low-quality vaccine. The risk of putting it into use. At the same time, the discolored protein is easier to distinguish and improves work efficiency.
Therefore, as long as we put this protein into the temperature indicator, the public's health benefits will be guaranteed. More importantly, economic losses will also be effectively cut for the benefit of the government and society.

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