Congratulations to the Austin UTexas 2019 iGEM team for their achievements!
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Team representatives receive the 2019 special award for Best Measurement!
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Austin UTexas tied with the Grand Prize Winner!
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Members of the team during the poster session
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The team stands proudly with their achievements
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The team strikes a pose for the 2019 Jamboree
Metabolic burden is often overlooked when designing genetic devices.
We use modeling to determine how big of a metabolic burden would lead to evolutionary instability.
How Do We Measure Burden?
Burdensome parts are identified by measuring and analyzing the growth rates of each part. The burdensome parts are further analyzed to determine the types of burden that they produce, which is achieved by observing GFP expression rates.
We have measured the burden of 330 parts from iGEM distribution kits
Impact on Synthetic Biology Community
We measured 330 parts from iGEM distribution kits, which includes frequently used promoters, coding regions, terminators, ribosome binding sites, and many other types of BioBricks. Synthetic biologists and iGEM students rely on the constructs within the iGEM registry without knowing if those parts are reliable. With our “Burdenometer," researchers can now assess the burden associated with those parts and choose more evolutionarily stable constructs. This information is important if a specific type of output is expected, maximizing productivity is a priority, or long-term propagation is pursued. It is also useful when troubleshooting cultivation failure. However, we are not confined to just these 330 parts! Synthetic biologists can now use our standardized measurement system to determine the burden of any genetic part that interests them.
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