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− | + | congresswoman Xiomara Rodríguez</div> | |
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− | + | Melvin Núñez from the PRN political party.</div> | |
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+ | class="img-fluid" style="height:500px;"> | ||
+ | <div class="numbertext description-text">Reunion with Ramón Carranza | ||
+ | from the PAC political party.</div> | ||
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− | + | <h3>Health Care System</h3> | |
− | + | <p>In a meeting with Dr. Fernando Morales and Dr. Gustavo Leandro, we talked about the prospects of | |
− | + | synthetic biology in health. In regards of their interest on the topics discussed, they helped | |
− | + | us organize a broadcast event in the National Hospital of Geriatrics and Gerontology, Dr. Raúl | |
− | + | Blanco Cervantes Hospital, which is also a WHO collaborative center. | |
− | + | </p> | |
+ | <p>The event was attended by 72 health professionals (the list of attendance is shown in the | ||
+ | following table). Participation was not only from the Dr. Raúl Blanco Cervantes Hospital, but | ||
+ | also from the infectology department of San Juan de Dios Hospital, both of them belong to the 29 | ||
+ | public hospitals of our country. It was important for us to exchange ideas with experts of both | ||
+ | institutions because they frequently attend cases of multidrug resistant bacteria, which could | ||
+ | eventually be treated through synthetic biology solutions. | ||
+ | </p> | ||
+ | <p>During the event, we were able to share with the audience the concept of synthetic biology, how | ||
+ | it is applied in Costa Rica and the possible use of bioengineered microorganisms as treatment. | ||
+ | The response of the participants about the topic was positive; however, we were interested to | ||
+ | know if they considered that a bioengineered probiotic as a therapeutic was a possible option in | ||
+ | our healthcare system. Among the comments we received, doctors reaffirmed to us the importance | ||
+ | of divulging this new kind of treatments, so that the public is more recipient of it and less | ||
+ | scared about its side effects. In words of one of the doctors: “if you publish, communicate and | ||
+ | socialize your treatment, then it is easier for us to suggest it as a therapeutic to patients | ||
+ | that have heard about it, in contrast with those who have not”. | ||
+ | </p> | ||
+ | <p>Hand in hand with the above, another engagement activity we did in the Dr. Raúl Blanco Cervantes | ||
+ | Hospital consisted in providing the information of the booklet to various patients and | ||
+ | companions. As this hospital is specialized in the elderly, we were able to share about | ||
+ | antibiotic resistance with a vulnerable public. Must of patients were really interested on the | ||
+ | topic and they took their time to read the information provided and ask us questions. Therefore, | ||
+ | in the hospitals we were able to bring synthetic biology as an alternative closer to the Costa | ||
+ | Rican healthcare system and final beneficiaries. | ||
+ | </p> | ||
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− | + | <h3>Academic Talks | |
− | + | </h3> | |
− | + | <p>Costa Rica is recognized as one of the leading countries in terms of education in Latin America. | |
− | + | However, for Costa Rican educational policy and practice there’s a lot to improve in the field | |
− | + | of science and technology. Within it, synthetic biology is undoubtedly an unexplored topic in | |
− | + | Costa Rican education. | |
− | + | </p> | |
− | + | <p>Therefore, our team gave the booklet and talked to high school and undergrad students who aren’t | |
− | + | able to learn of it in order place. We introduced basic concepts of synthetic biology such as | |
− | + | genetic modification, recombinant proteins, domain fusions, among others. We also explained our | |
− | + | project diffEASY, raised awareness about the situation of Costa Rican politics regulation and | |
− | + | mainly, motivated them to don’t lose their interest to understand their surroundings. | |
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− | + | <div class="numbertext description-text">Talk at the "Colegio Madre del Divino Pastor"</div> | |
− | + | </div> | |
− | + | <h3>Press Release</h3> | |
− | + | <p>Our booklet aimed to engage synthetic biology with Costa Rican society too, considering the | |
− | + | beliefs of general population, some of them based on disinformation. Therefore, we reached | |
− | + | different press media from our country to help us inform a larger public. It is important to | |
− | + | emphasize that this kind of involvement with general public is key in the improvement of an | |
− | + | informed and critical society, in order to create awareness of the possibilities with GMOs and | |
− | + | their limitations. | |
− | + | </p> | |
− | + | <p>Fortunately, we were featured in multiple press releases, including social media, radio and | |
− | + | television. Notably, TV interviews were hosted in the main TV news channels of the country. | |
− | + | Also, thanks to Kantar Media Ibope, software for press monitoring used by ITCR, here we show you | |
− | + | a summary with all the press publications and their reach, which had a total of 204 373 people. | |
− | + | </p> | |
− | + | <h3>Our booklet design</h3> | |
− | + | <p>(Hover mouse over to stop)</p> | |
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+ | </div> | ||
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− | + | <h2>Antibiotic resistance: A global problem</h2> | |
− | + | <p>Since we were brainstorming about possible problems to be addressed, we quickly (not so much) | |
− | + | stumbled upon the issue of antibiotic resistance. This phenomenon is expected to provoke up to 10 | |
− | + | million annual deaths by 2050 (O'Neill, 2014), possibly the first death cause worldwide. This has | |
− | + | lead the United Nations to declare antibiotic resistance as one of the greatest threats to global | |
− | + | public health. </p> | |
− | + | <h2>Resistant bacterial infections: Choosing our project aim</h2> | |
− | + | <p>Antibiotic resistance is an exponential growing problem around the world and it has a very serious | |
− | + | social impact. Looking for a solution to this problem we focused on a gastrointestinal pathogen, | |
− | + | <i>Clostridioides difficile</i>. This bacteria infected patients in 21 of the 29 hospitals of Costa Rica | |
− | + | from 2011-2014. Even one of our team members has suffered from this illness.</p> | |
− | + | <h2>Problems: </h2> | |
− | + | <h3>Awareness for antibiotic resistance is lacking</h3> | |
− | + | <p>There is a worldwide lack of knowledge on the subject of microbial resistance to antibiotics and Costa Rica | |
− | + | is not the exception. Globally, the main cause of this problem is the misuse of antibiotics, leading | |
− | + | to the survival of some resistant bacteria, able to spread again. Also, the bad waste management of | |
− | + | these drugs contributes to increase resistant bacteria. This bacteria can later transfer their | |
− | + | resistance to human microbiota (van Rijn et al., 2019). </p> | |
− | + | <p>Research is being conducted to discover new antibiotics. However, only two new antibiotic classes | |
− | + | (lipopeptides and oxazolidinones) have been developed and approved by international drug agencies | |
− | + | (US Food and Drug Administration and European Medicines Agency) in the last three decades | |
− | + | (Tacconelli et al., 2018). The field of antibiotics is not lucrative enough for pharmaceutical | |
− | + | companies and newly discovered compounds remain similar in function to current antibiotics. As a | |
− | + | result, only a few large companies such as GlaxoSmithKline, Novartis, Merck and Roche are still | |
− | + | actively engaged in antibiotic research and development (Jackson, Czaplewski & Piddock, 2018).</p> | |
− | + | <p>During our problems exploration we realized antibiotic resistance consists on the two problems | |
− | + | mentioned above. Therefore, we decided to go out the lab to help create awareness on antibiotic | |
− | + | resistance in our country and prove the prevalence of antibiotic resistance bacteria using the agar | |
− | + | antibiotic resistance test.</p> | |
− | + | <h3>Larger agar antibiotic resistance test</h3> | |
− | + | <p>We went to the streets to have a closer encounter with people. In total we sampled 10 different | |
− | + | places of Costa Rica: La Agonía Park in Alajuela, Central Park in Heredia, Central Park in Cartago | |
− | + | and seven different places in San Jose (Central Park, El Mercado Central, La Sabana Metropolitan | |
− | + | Park, France Park and the buses stations from Limón, Puntarenas and Liberia). We talked to 100 Costa | |
− | + | Ricans, explained them a little bit of our problem and sampled their mouth with sterile swabs and | |
− | + | following the National Health Ministry regulations. Samples were grown in petri dishes supplemented | |
− | + | with amoxicillin (antibiotic most commonly used in Costa Rica) for 24h at 37 °C. </p> | |
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Revision as of 01:14, 21 October 2019
Human practices are meant to explain why our project is important to the world. Here we present how we do an intense work to inform the people of Costa Rica about Synthetic Biology, iGEM and the new possibilities of Engineered Probiotics.