Why Modeling?
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PET degradation by Chlamydomonas reinhardtii
A C. reinhardtii which expresses and secretes the enzymes PETase and MHETase could pose as a solution for the problem of micro-plastic polluted water. Nevertheless, the viability of PET-degradation by C. reinhardtii at a larger scale is yet unknown. To assess the efficiency of PET-degradation by C. reinhardtii, a model of the expression, secretion and kinetics of the enzymes PETase and MHETase in C. reinhardtii was designed. The goal of the model is to simulate the degradation of PET while taking into account the parameters of enzyme kinetics, expression rate, secretion rate and cultivation density. By varying the parameters, an approximation on PET degradation under various conditions can be made to examine what the appropriate parameters are for an optimal PET-degradation. To achieve this, the kinetics of MHETase and the optimized PETase (I179F) were taken from literature (Palm et al., 2019) (Ma et al., 2019).
1 mg of PET is degraded after 22.2 hours
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