Team:SYSU-Medicine/Model
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OVERVIEW
To make a more critical experiment criteria and bring our project a promotion for clinical use, we established 9 models to describe the process. Our modeling contained 2 parts. In part 1, M1 Cultivation searched for the best time to collect M1. And Injection System helped us find the rule of interaction of M1, tumor cells, prodrug and actinomycin D, by which we find the best time for injection. These two criteria is more objective and scientific compared to empirical method. In part 2, Targeting Ability, Safety and Effectiveness showed that our method was safe and effective. Future section provided a probable prediction on human body. In a sense, these result of models fit for biological and medical study, and are confirmed by our experiment. And our result provides guidance for our experiment, enhancing the coming research.download PDF
our github here
M1 Cultivation
Aim: To find the best time when the copy rate and the number of M1
with 2 mutation sites is the highest.
Method: ODE model, Poisson Process.
Injection System
Aim: To find complex concentration variation of tumor cells, M1, pro-
drug and actinomycin D in the experiment on mouse. And to find the
time-varying concentration distribution of M1.
Method: Improved Michaelis-Menten Equation, Compartment Model, Impulsive Differential
Equation.
Targeting Ability, Safety and Effectiveness
Aim: To confirm the targeting ability, safety and effectiveness of our
system on animals.
Method: Improved ODE Model, comparison, t-test, Fitting.
Future
Aim: To give a prediction of our method on human body, and provide
a treatment model with higher precision.
Method: BP Neural Network, DTR.
Conclusion
Aim: To summarize the advantages and disadvantages of our model, and give an expectation for the future.