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Learning from previous research, we found that volatile organic metabolites (VOM) can be found in many human disease samples. We then consulted some medical doctors to investigate the recent devlopment in clinical practice.

Dr. Chun-Ying Wu 吳俊穎

Current Position

  • Chief, Division of Translational Research, Taipei Veterans General Hospital
  • Professor, Division of Gastroenterology & Hepatology, Taipei Veterans General Hospital
  • Joint Appointment Researcher, National Institute of Cancer Research

Principle Expertise

  • Hepatoma
  • Stomach cancer
  • Functional dyspepsia

Dr. Wu briefly introduced the recent research and devlopment in Gastroenterology. As not only a doctor, but also a researcher, he gave us some advice about our research direction, making us think of our aim (to detect disease or to cure disease) and of taking what disease as our example. After discussing with him, we narrowed down our topics to early screening of disease, and found that many gastrointestinal diseases can be our potential targets. To learn more about gastrointestinal diseases and to find out what disease is harmful yet the patients are often diagnosed in late stages, we visited Dr. Chen.

Dr. Wei-Shone Chen 陳維熊

Current position

  • Former Dean, School of Medicine, National Yang-Ming University, Taiwan
  • Professor of Surgery, School of Medicine, National Yang-Ming University, Taiwan
  • Attending Physician, Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taiwan
  • Chairman, Global Health Education Society

Principle expertise

  • Surgery of colorectal cancer
  • Research of colorectal cancer
  • Cancer epidemiology
  • Medical education

Dr. Chen told us that most abnormalities in colon, can be easily seen by colonoscopy; however, colorectal cancer and constipation are two major tricky issues in the field, so we aimed at collorectal cancer.

In addition to clinical field, we also noticed the importance of our project in commerce and industry. Moreover, after discussing with Dr. Chen, we found that probiotics may be used as a detector. Thus, we invited Professor Tsai.

Dr. Ying-Chieh Tsai 蔡英傑

Current position

  • Chief founder and advisor of BENED BIOMEDICAL
  • Former Professor, Institute of Biochemistry and Molecular Biology, National Yang Ming University

Principle expertise

  • Biological technology
  • Molecular biology
  • Probiotics

As the founder of BENED BIOMEDICAL, he told us his experience about research, showing us some research ongoing in his company.

Fig 1. Photo with Dr. Ying-Chieh Tsai.

Targeting Lung Diseases


However, we faced difficulties that there are few receptors can bind with the gas generated by gastrointestinal diseases. Finally, we taked lung cancer and tuberculosis disease as our example.

Dr. Hsiao-Yu Yang 楊孝友

Current position

  • Associate professor, College of Public Health, National Taiwan University
  • Attending physician, department of environmental and occupational medicine, National Taiwan University Hospital

Principle expertise

  • ILO Certified Intensive Reader of Pneumoconiosis
  • Occupational medicine
  • Forensic Medicine

After making sure that our project is related to screening of lung disease, we had a conference call with Dr. Yang, who was in the USA for researching at that time. Since Dr. Yang is the expert in Pneumoconiosis detection, he told us a great number of details about the detection of respiratory disease. For example, he told us that the we should set up a procedure of criteria of gas collection, for the reason that the consequence of collection will absolutely influence the next stage of test.

He also invited us to participate in the oral defense of his postgraduate because the topic of thesis is also related to the respiratory disease. From the speech delivered from his student, Chian Zeng, we found there are still imperfect, which also inspired us to make our project better.

Fig 2. Photo with Dr. Hsiao-Yu Yang's graduate student.

Because our project is related to quick screening of Tuberculosis, we decided to visit Dr. Su, who is the expert of Tuberculosis and other lung diseases.

Dr. Wei-Juin Su 蘇維鈞

Current position

  • Director, Division of Pulmonary Immunology & Infectious Diseases, Taipei Veterans General Hospital, Taiwan
  • Chairman, Taiwan Society of Tuberculosis and Lung Disease
  • Chairman, Taiwan Association of Respiration Education

Principle expertise

  • Tuberculosis
  • Asthma
  • Lung cancer

Dr. Su told us that the related topics had been researched for decades, and a great number of scientists are devoted to improving the original diagnosis way or creating a totally new method, which means it’s a field hard to bforreak through.

He advised that we should emphasize on the design and method of our projects, trying to find the advantages and display them, such as whether our diagnosis way is more sensitive of effective than the original ones. He also told us that the different stage of tuberculosis may also influence the result of diagnosis so that we should consider more details which we will faced in our project.

Thanks to the comments from Dr. Su, we were able to find the points which should be revised or improved in our research. The communication with Dr. Su also make us notice how complicated the tuberculosis is, which means we should work harder to make our project better.

Fig 3. Photo with Dr. Wei-Juin Su.