Team:Fudan/Human Practices
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Human Practices
Limits of Existing Treatments
Last year when Yichen Gong( One of our team members) was doing voluntary work at Obstetrics and Gynecology Hospital of Fudan University, she found that lots of babies were suffering from lactose intolerance. She discussed with us and we found that this disease was very common in China, but the existing treatment is inconvinent. click to see more...
Survey
When we were planning our project, we decided to use Nissle 1917( a kind of e.coli) to achieve our goal.
Among the gram-negative microorganisms with probiotic properties, E.coli strain Nissle 1917 is probably the most intensively investigated bacterial strain today. Since nearly 100 years, the Nissle strain is used as the active pharmaceutical ingredient in a licensed medicinal product that is distributed in Germany and several other countries. Over the last few decades, novel probiotic activities have been detected, which taken together are specific of this versatile E. coli strain. Nissle can impede the growth of Salmonella strains, so it is used to treat Gastrointestinal diseases. Also, efficacy was shown in the treatment of acute and chronic diarrhea in toddlers and children.[1] Based on these properties, by modifying Nissle, we can make it achieve our goal.
[1]: Michael Schultz, Jeremy Paul Burton. Escherichia coli Nissle 1917[J]. The Microbiota in Gastrointestinal Pathophysiology, pp.59-69
Since we were going to put Nissle into babies' intestinal tract, we wondered whether parents would accept this treatment, so we went back to Obstetrics and Gynecology Hospital of Fudan University again to conduct a survey. click to see more...
Safety
Most parents accept these kind of treatment, but they still concerned about safety problems. We found one of the members of China Biosafety Committee, Baorong Lu, for advice. Also, we used our collaboration team UCAS's project to ensure Nissle won't grow in the environment. click to see more...
Adhesion VS Competition
Ordinary probiotics can't stay in human body for a long time, so we decide to improve Nissle's adhesion. Then we wanted to know whether improving it's adhesion is feasible, so we visited professor Lihui Feng, majoring in intestinal flora. She told us that improving adhesion isn't quite necessary, we should focus on bacterial competition. click to see more...
Market Preparation
In the further vision, we want to release our product into the market. Situations in the market is quite different with what in the laboratory. Though we haven't marketize our product yet, we have done some market preparation by consulting Hong Lv, a professor who is working on marketizing microbial products. By doing market preparation, we learned a lot about how a microbial products was released to the market. click to see more...
