Difference between revisions of "Team:ShanghaiFLS China/Demonstrate"

Latest revision as of 15:33, 21 October 2019

ShanghaiFLS_China: Model

Demonstrate

In our project, we rewired the homogeneous regulatory pathways of Pichia pastoris GS115 to improve its methanol metabolizing capabilities. When we consulted research professionals and industry leaders regarding the feasibility of our approach in industrial settings, most were not optimistic. To address this doubt, we constructed a model calculating the oxygen consumption and heat generation of our yeast strains, two main factors to be considered in industrial processes. We based our models on validated and published equations and data from our experiments. The results of our calculations confirm the potential industrial applications of our modified P. pastoris GS115 strains.

@@ Line 105: / Line 105: @@
                  <div class="col-md-8 w3layouts_banner_margin">
                      <h2 class="editContent">Demonstrate</h2>
-                     <p>When we asked professors and industrial leaders whether our project would be successful in the industry, they were not optimistic. However, due to constraints in our experimental settings, we were not able to demonstrate through experiments how our designs would work. This problem led us to construct a model, modifying existent formulas from literary works, to demonstrate this possibility. The rate of oxygen consumption and heat emission are two main factors to be considered in industrial processes, and our project mainly looks at methanol consumption. When we looked at the three factors separately in three models below, they all prove adequate possibilities of industrial production.</p>
+                     <p>In our project, we rewired the homogeneous regulatory pathways of <em>Pichia pastoris</em> GS115 to improve its methanol metabolizing capabilities. When we consulted research professionals and industry leaders regarding the feasibility of our approach in industrial settings, most were not optimistic. To address this doubt, we constructed a model calculating the oxygen consumption and heat generation of our yeast strains, two main factors to be considered in industrial processes. We based our models on validated and published equations and data from our experiments. The results of our calculations confirm the potential industrial applications of our modified <em>P. pastoris</em> GS115 strains.</p>
                  </div>
              </div>