Difference between revisions of "Team:NCKU Tainan"
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<h3>Abstract</h3> | <h3>Abstract</h3> | ||
| − | <p>Chronic Kidney | + | <p>Patients suffering from Chronic Kidney disease are unable to filter out uremic toxins inside the body due to a failing kidney. Accumulation of <i>p</i>-Cresol, one of the uremic toxins, have been associated with cardiovascular disease and worsening of Chronic Kidney Disease. To solve this problem, iGEM NCKU will be engineering <i>E. coli</i> Nissle, which is an FDA approved probiotic, to have two specific functions. First, to secrete bacteriocin and reduce the major gut <i>p</i>-Cresol producer, the <i>Clostridium</i> population. Second, to convert excess <i>p</i>-Cresol precursor, tyrosine into a harmless byproduct called <i>p</i>-Coumaric acid rather than <i>p</i>-Cresol. For biosafety concern, we knocked out the <i>yadF</i> gene to ensure <i>E. coli</i> will die when they enter the atmosphere. To provide additional aid in monitoring the level of <i>p</i>-Cresol in these patients’ body, we will also provide an open-source biosensing platform that uses live bacteria to detect specific compounds inside the blood. |
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</p> | </p> | ||
<h4>Contact Us</h4> | <h4>Contact Us</h4> | ||
Revision as of 16:36, 21 August 2019
Oh My Gut (Therapeutics)
Abstract
Patients suffering from Chronic Kidney disease are unable to filter out uremic toxins inside the body due to a failing kidney. Accumulation of p-Cresol, one of the uremic toxins, have been associated with cardiovascular disease and worsening of Chronic Kidney Disease. To solve this problem, iGEM NCKU will be engineering E. coli Nissle, which is an FDA approved probiotic, to have two specific functions. First, to secrete bacteriocin and reduce the major gut p-Cresol producer, the Clostridium population. Second, to convert excess p-Cresol precursor, tyrosine into a harmless byproduct called p-Coumaric acid rather than p-Cresol. For biosafety concern, we knocked out the yadF gene to ensure E. coli will die when they enter the atmosphere. To provide additional aid in monitoring the level of p-Cresol in these patients’ body, we will also provide an open-source biosensing platform that uses live bacteria to detect specific compounds inside the blood.
Contact Us
FB: https://www.facebook.com/igem.ncku/
Email: igem.ncku.tainan@gmail.com
Instagram: https://www.instagram.com/igemncku/?igshid=umwewh0j47m5
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