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<div class="row w3pvt_banner_info"> | <div class="row w3pvt_banner_info"> | ||
<div class="col-md-8 w3layouts_banner_margin"> | <div class="col-md-8 w3layouts_banner_margin"> | ||
− | <h3 class="editContent"> | + | <h3 class="editContent"><em>Pichia Pastoris</em> GS115:</h3> |
<h2 class="editContent">The Methanol Converter</h2> | <h2 class="editContent">The Methanol Converter</h2> | ||
− | <p> | + | <p>Methanol is a major byproduct of the coal industry. Engineered <em>Pichia pastoris</em> GS115, a strain of methylotrophic yeast, is capable of converting methanol into medical compounds such as the insulin precursor and lovastatin. However, this metabolism pathway is highly specific and results in significant oxygen consumption and heat generation, which has limited its industrial applications. We addressed this issue by improving the methanol conversion rate in <em>P. pastoris</em> by re-engineering its homogeneous circuits expressing the transcription factors that would up-regulate the expression of AOX1, the protein allowing it to metabolize methanol. Through our multiple rounds of experiments, we eventually acquired strains that are capable of yielding an up to 20% increase in total GFP production per gram methanol compared to the wildtype.</p> |
− | + | <a href="https://2019.igem.org/Team:ShanghaiFLS_China/Design">Design</p> | |
− | + | <a href="https://2019.igem.org/Team:ShanghaiFLS_China/Experiments">Experiment</a> | |
+ | <a href="https://2019.igem.org/Team:ShanghaiFLS_China/results">Results</a> | ||
+ | <a href="https://2019.igem.org/Team:ShanghaiFLS_China/Parts">Parts</a> | ||
</div> | </div> | ||
</div> | </div> | ||
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<section class="about py-5" id="about"> | <section class="about py-5" id="about"> | ||
<div class="container py-3"> | <div class="container py-3"> | ||
− | <h3 class="heading"> | + | <h3 class="heading">About us</h3> |
<div class="row about-grids"> | <div class="row about-grids"> | ||
− | + | <p class="my-4">We are a diverse group of high school students from China, studying in Beijing, Tianjin, the United States or Switzerland, as well as in Shanghai Foreign Language School. We have different hobbies, ambitions, and views towards bioengineering. We also have different jobs o realize this complicated project. For more information about us, please click on the links below:<br /><br /></a> | |
− | <p class="my-4"> | + | <a href="https://2019.igem.org/Team:ShanghaiFLS_China/Team"> Team Members </a> |
− | <a href="https://2019.igem.org/Team:ShanghaiFLS_China | + | <a href="https://2019.igem.org/Team:ShanghaiFLS_China/Attributions"> Attributions </a> |
− | + | </div> | |
− | + | ||
− | <a href="https://2019.igem.org/Team:ShanghaiFLS_China/ | + | |
− | + | ||
− | </div> | + | |
</div> | </div> | ||
</section> | </section> |
Revision as of 05:13, 21 October 2019
About us
We are a diverse group of high school students from China, studying in Beijing, Tianjin, the United States or Switzerland, as well as in Shanghai Foreign Language School. We have different hobbies, ambitions, and views towards bioengineering. We also have different jobs o realize this complicated project. For more information about us, please click on the links below:
Team Members
Attributions