Difference between revisions of "Team:DTU-Denmark"

Line 599: Line 599:
 
      
 
      
 
     desc_p2 = "Whilst filamentous fungi are hugely important in industry, a disproportionately small number of iGEM teams have worked with this group of organisms.  
 
     desc_p2 = "Whilst filamentous fungi are hugely important in industry, a disproportionately small number of iGEM teams have worked with this group of organisms.  
−
The 2018 DTU iGEM team Hyphae Hackers exploited filamentous fungi in their project but realised that the accessibility of parts was lacking severely compared to that of bacteria and yeasts (e.g. Escherichia coli and Saccharomyces cerevisiae).";
+
The 2018 DTU iGEM team Hyphae Hackers exploited filamentous fungi in their project but realized that the accessibility of parts was lacking severely compared to that of bacteria and yeasts (e.g. Escherichia coli and Saccharomyces cerevisiae).";
 
      
 
      
 
     desc_p3 = "In the 15 years of iGEM, 2754 teams have participated but until last year only 5 had worked in filamentous fungi, and these accounted for less than 5% of the promoters in the iGEM registry.";
 
     desc_p3 = "In the 15 years of iGEM, 2754 teams have participated but until last year only 5 had worked in filamentous fungi, and these accounted for less than 5% of the promoters in the iGEM registry.";
 
      
 
      
−
     desc_p4 = "The lack of filamentous fungal parts therefore resulted in great difficulties for the 2018 DTU iGEM team with transforming the fungi and achieving the desired expression. While several promoter libraries exist for bacteria and eukaryotic organisms such as yeast and mammalian cells, there are currently no such libraries for filamentous fungi in the scientific literature (3).";
+
     desc_p4 = "The lack of filamentous fungal parts, therefore, resulted in great difficulties for the 2018 DTU iGEM team with transforming the fungi and achieving the desired expression. While several promoter libraries exist for bacteria and eukaryotic organisms such as yeast and mammalian cells, there are currently no such libraries for filamentous fungi in the scientific literature (3).";
 
      
 
      
 
     desc_p5 = "The Technical University of Denmark harbors unique facilities and personnel with great expertise in working with synthetic biology in filamentous fungi. The department furthermore has a fermentation core which allows fungi to be examined in multiple scales and under differing conditions as well as control of the pH and monitoring of CO2-production during growth.";
 
     desc_p5 = "The Technical University of Denmark harbors unique facilities and personnel with great expertise in working with synthetic biology in filamentous fungi. The department furthermore has a fermentation core which allows fungi to be examined in multiple scales and under differing conditions as well as control of the pH and monitoring of CO2-production during growth.";

Revision as of 13:18, 21 October 2019

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Library of Engineered Aspergillus Promoters

A World of Biotechnology

Many everyday products are produced using microorganisms such as fungi. The production of these products is regulated by small DNA sequences called promoters. These are necessary tools to optimize the yield of the desired product and minimize the yield of others.

Promoters

These promoters work as regulators for gene expression. Think of it as a gear in a car. Some gears make the car go fast, and others lower the speed. This is done by controlling the transcription of a gene, as it determines the strength at which the RNA polymerase can bind.

Our Library

Therefore we are creating a library of synthetic fungal promoters that are: predictable, robust, and scalable. These were designed using special software based on sequence conservation. In the design we have included feedback from relevant companies and scientists, meaning that the promoters are useful in both industry and academia.

Did you know?

The total annual revenue from enzymes produced by Aspergillus spp. is 480 mio USD per year [3].

A small step for man, a giant LEAP for iGEM