Difference between revisions of "Team:DTU-Denmark"
| Line 535: | Line 535: | ||
desc_p1="Filamentous fungi are responsible for 50% of all industrially produced enzymes and 10% of all known bioactive compounds, therefore this multi-billion dollar industry is a big part of everyday life. Yet, while this is impressive, filamentous fungi can be utilized in the production of many other compounds (1)(2)."; | desc_p1="Filamentous fungi are responsible for 50% of all industrially produced enzymes and 10% of all known bioactive compounds, therefore this multi-billion dollar industry is a big part of everyday life. Yet, while this is impressive, filamentous fungi can be utilized in the production of many other compounds (1)(2)."; | ||
| − | desc_p2 = "Whilst filamentous fungi are hugely important in industry, a disproportionately small number of iGEM teams have worked with this group of organisms. | + | desc_p2 = "Whilst filamentous fungi are hugely important in industry, a disproportionately small number of iGEM teams have worked with this group of organisms. The 2018 DTU iGEM team Hyphae Hackers exploited filamentous fungi in their project but realized that the accessibility of parts was lacking severely compared to that of bacteria and yeasts (e.g. Escherichia coli and Saccharomyces cerevisiae)."; |
| − | The 2018 DTU iGEM team Hyphae Hackers exploited filamentous fungi in their project but realized that the accessibility of parts was lacking severely compared to that of bacteria and yeasts (e.g. Escherichia coli and Saccharomyces cerevisiae)."; | + | |
desc_p3 = "In the 15 years of iGEM, 2754 teams have participated but until last year only 5 had worked in filamentous fungi, and these accounted for less than 5% of the promoters in the iGEM registry."; | desc_p3 = "In the 15 years of iGEM, 2754 teams have participated but until last year only 5 had worked in filamentous fungi, and these accounted for less than 5% of the promoters in the iGEM registry."; | ||
Revision as of 13:23, 21 October 2019
A World of Biotechnology
Many everyday products are produced using microorganisms such as fungi. The production of these products is regulated by small DNA sequences called promoters. These are necessary tools to optimize the yield of the desired product and minimize the yield of others.
Promoters
These promoters work as regulators for gene expression. Think of it as a gear in a car. Some gears make the car go fast, and others lower the speed. This is done by controlling the transcription of a gene, as it determines the strength at which the RNA polymerase can bind.
Our Library
Therefore we are creating a library of synthetic fungal promoters that are: predictable, robust, and scalable. These were designed using special software based on sequence conservation. In the design we have included feedback from relevant companies and scientists, meaning that the promoters are useful in both industry and academia.
The total annual revenue from enzymes produced by Aspergillus spp. is 480 mio USD per year [3].
A small step for man, a giant LEAP for iGEM
