Difference between revisions of "Team:Jilin China"

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<section class="s0 banner" style="padding: 0 0;">
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<div class="title"><img alt="" src="https://static.igem.org/mediawiki/2019/f/f8/T--Jilin_China--Main--Words_-_Title.svg"/></div>
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<canvas id="maincabg" width="1920px" height="1080px" style="height:100%; height:auto;display: block;position: absolute;top: 0px; z-index: -1;"></canvas>
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</section>
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<section class="s1 introduction left">
 +
<div></div>
 +
<div class="text">
 +
<h1 class="bg-white">What's VVC?</h1>
 +
<p>Vulvovaginal candidiasis (VVC) has been recognized as one of the most common infections in female reproductive organs. </p>
 +
<p>VVC is mainly caused by Candida albicans (C. albicans), accounting for more than 85% of the incidence, which seriously affects the normal life of women.</p>
 +
</div>
 +
<div class="clear"></div>
 +
</section>
 +
<section class="s2 symptom">
 +
<div class="digits">
 +
<p class="digit">70-75%</p>
 +
<p class="explain">of women will suffer from VVC at least once in thier life time.</p>
 +
<p class="digit">40-45%</p>
 +
<p class="explain">will have 2 or more episodes.</p>
 +
</div>
 +
<div class="small-bg">
 +
<div class="title">
 +
<h2 class="bg-colored">Symptoms</h2>
 +
</div>
 +
<div class="image">
 +
<img alt="" src="https://static.igem.org/mediawiki/2019/7/71/T--Jilin_China--Main--Girl_under_Period.svg" />
 +
</div>
 +
<div class="text">
 +
<p>Abnormal Vaginal Discharge</p>
 +
<p>Genital and Vaginal burning</p>
 +
<p>External Dysuria</p>
 +
<p>Itching and Redness</p>
 +
</div>
 +
 +
<div class="clear"></div>
 +
</div>
 +
</section>
 +
<section class="s3 current-treatment right">
 +
<div class="text">
 +
<h1 class="bg-white">How to Treat?</h1>
 +
<p>Till now, as a commonly used antifungal drug for VVC treatment, vaginal azole preparations can inhibit the growth of C. albicans, or kill them directly.</p>
 +
</div>
 +
<div class="clear"></div>
 +
</section>
 +
<div class="interspace">
 +
<p>HOWEVER</p>
 +
<div class="clear"></div>
 
</div>
 
</div>
−
</div>
+
<section class="s4 resistance right">
 +
<div class="text">
 +
<p id="ssss">The widespread usage of antifungal drugs and the increase in the number of fungal infections have led to the emergence of drug resistance, even the repeated recurrence to VVC of patients.</p>
 +
</div>
 +
<div class="clear"></div>
 +
<div class="button colored"><a href="https://2019.igem.org/Team:Jilin_China/Background"><p>Learn More about The Background</p></a></div>
 +
<div class="clear"></div>
 +
</section>
 +
<section class="s5 reverse">
 +
<p>But, there is a</p>
 +
<p>New Therapy for Vulvovaginal Candidasis:</p>
 +
<div class="clear"></div>
 +
</section>
 +
<section class="s6 our-system">
 +
<h1>Our Systems</h1>
 +
<div class="sensing">
 +
<h2>Sensing System</h2>
 +
<p style="margin-bottom:30px;margin-top:30px;  ">Sensing system can sense C. albicans and activate the downstream gene.</p >
 +
<img alt="" src="https://static.igem.org/mediawiki/2019/5/56/T--Jilin_China--Main--Words_-_Sensing_System.svg" />
 +
<p></p>
 +
</div>
 +
  
−
    </div>
+
<div class="theraputic">
 +
<h2>Theraputic System</h2>
 +
<div>
 +
<div class="effector1"><p>LL37 can perforate the cell membrane of C.albicans.</p><img alt="" src="https://static.igem.org/mediawiki/2019/2/2e/T--Jilin_China--Main--LL37.svg"/></div>
 +
<div class="effector2"><p>The β-1,3-glucanase can disrupt the </br>biofilm of C. albicans.</p><img alt="" src="https://static.igem.org/mediawiki/2019/3/32/T--Jilin_China--Main--beta-1%EF%BC%8C3-glu.svg"/></div>
 +
<div class="effector3"><p>BDSF can inhibit hypha formation </br>by C. albicans.</p><img alt="" src="https://static.igem.org/mediawiki/2019/e/ed/T--Jilin_China--Main--BDSF.svg"/></div>
 +
<div class="effector4"><p>Msp1 can destabilize the hyphae of C. albicans.</p><img alt="" src="https://static.igem.org/mediawiki/2019/c/cc/T--Jilin_China--Main--Msp1.svg"/></div>
 +
</div>
 +
</div>
 +
<div class="clear"></div>
 +
<div class="button colored"><a href="https://2019.igem.org/Team:Jilin_China/Design"><p>Learn More about Our Design</p></a></div>
 +
<div class="clear"></div>
 +
</section>
 +
<section class="s7 hp">
 +
 
 +
 
 +
 
 +
 
 +
 
 +
<h1 class="bg-white">Practices Facilitated Our Project</h1>
 +
 
 +
<div class="third_s">
 +
  <div id="third_1">
 +
 
 +
  <div class="t1inb"><div class="t1nb0"><img class="yilei"  src="https://static.igem.org/mediawiki/2019/9/96/T--Jilin_China--Main--HP_Brain_Half.svg" width="60%" ></div><div class="t1nb1"><div class="t1nb11">Initially, we brainstormed to decide our project. We came up with three projects: General White Resistance, Vaginitis Treatment and Plant Resistance Improvement</div></div></div>
 +
 
 +
  <div class="t1inb "><div class="t1nb0"><img class="erlei" class="imgdo"  src="https://static.igem.org/mediawiki/2019/c/c7/T--Jilin_China--Main--HPwomen.svg" height="90%" ></div><div class="t1nb1 t1do"><div class="t1nb11">After attending the women's lecture, we decided to study the method of treating vaginitis and confirmed VVC through questionnaire collection.</div></div></div>
 +
 
 +
  <div class="t1inb"><div class="t1nb0"><img class="yilei"  src="https://static.igem.org/mediawiki/2019/3/3a/T--Jilin_China--Main--HP_Brain_Full.svg" width="60%" ></div><div class="t1nb1"><div class="t1nb11">After interviewing patients and doctors, we learned about the current problems in the treatment of VVC and brainstormed the project 1.0.</div></div></div>
 +
 
 +
  <div class="t1inb "><div class="t1nb0"><img class="sanlei aha"    src="https://static.igem.org/mediawiki/2019/5/5d/T--Jilin_China--Main--HP1.0.svg" width="45%" ></div><div class="t1nb1 t1do"><div class="t1nb11">After having brainstormed project 1.0.We interviewed professors give us suggestions to improve our project 1.0 and obtained project 2.0.</div></div></div>
 +
 
 +
  <div class="t1inb"><div class="t1nb0"><img class="sanlei"  src="https://static.igem.org/mediawiki/2019/7/72/T--Jilin_China--Main--HP2.0.svg" width="45%" ></div><div class="t1nb1"><div class="t1nb11"> We interviewed experts for a comprehensive assessment of our project. To make project practical, we interviewed ethical experts, pharmacies and pharmacies.</div></div></div>
 +
  <div id="hparrow"><img  src="https://static.igem.org/mediawiki/2019/c/c7/T--Jilin_China--Main--HP_arrow.svg" width="130%"></div></div>
 +
  </div>
 +
  </div>
 +
 
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<section class="s8 model right">
 +
<h1 class="bg-white">Model</h1>
 +
<div class="text">
 +
 
 +
<p>Our project is well conducted by Model in terms of experiments and prediction of future application. Our Model is constituted with</br></br>1. C. albicans Sensing Model</br>2. Gene Concentration Prediction Model</br>3. Market Prediction Model</p>
 +
</div>
 +
<div class="clear"></div>
 +
<div class="button colored"><a href="https://2019.igem.org/Team:Jilin_China/Model"><p>Learn More about Our Model</p></a></div>
 +
<div class="clear"></div>
 +
</section>
 +
 
 +
 
 +
 
 +
 
 +
<section class="s9 more">
 +
<h1>In Case You Missed Them:</h1>
 +
<div class="bottons">
 +
<div id="bbgd"  class="botton otr"><p>Background</p><a class="foota otr1" href="https://2019.igem.org/Team:Jilin_China/Background"></a></div>
 +
<div id="design" class="botton otr"><p>Design</p><a class="foota otr1" href="https://2019.igem.org/Team:Jilin_China/Design"></a></div>
 +
 
 +
<div id="result" class="botton otr"><p>Result</p><a class="foota otr1" href="https://2019.igem.org/Result"></a></div>
 +
 
 +
<div id="par" class="botton otr"><p>Our Parts</p><a class="foota otr1" href="https://2019.igem.org/Team:Jilin_China/Parts"></a></div>
 +
 
 +
<div id="hpp" class="botton otr"><p>Practices</p><a class="foota otr1" href="https://2019.igem.org/Team:Jilin_China/Human_Practices"></a></div>
 +
<div id="medal" class="botton otr"><p>Medals</p><a class="foota otr1" href="https://2019.igem.org/Team:Jilin_China/Medals"></a></div>
 +
</div>
 +
<div class="clear"></div>
 +
</section>
 +
 
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 +
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 +
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 +
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 +
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 +
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 +
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 +
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Revision as of 16:45, 20 October 2019

Team
Project
Lab
Model
Parts
HP
Judging
Home
Members
Collaborations
Attributtions
Background
Description
Design
Result
Demonstrate
Notebook
Protocols
Safety
Model
Our parts
Improvement
Measurement
Integrated
Engagement
Juding Form
Medals






What's VVC?

Vulvovaginal candidiasis (VVC) has been recognized as one of the most common infections in female reproductive organs.

VVC is mainly caused by Candida albicans (C. albicans), accounting for more than 85% of the incidence, which seriously affects the normal life of women.

70-75%

of women will suffer from VVC at least once in thier life time.

40-45%

will have 2 or more episodes.

Symptoms

Abnormal Vaginal Discharge

Genital and Vaginal burning

External Dysuria

Itching and Redness

How to Treat?

Till now, as a commonly used antifungal drug for VVC treatment, vaginal azole preparations can inhibit the growth of C. albicans, or kill them directly.

HOWEVER

The widespread usage of antifungal drugs and the increase in the number of fungal infections have led to the emergence of drug resistance, even the repeated recurrence to VVC of patients.

Learn More about The Background

But, there is a

New Therapy for Vulvovaginal Candidasis:

Our Systems

Sensing System

Sensing system can sense C. albicans and activate the downstream gene.

Theraputic System

LL37 can perforate the cell membrane of C.albicans.

The β-1,3-glucanase can disrupt the
biofilm of C. albicans.

BDSF can inhibit hypha formation
by C. albicans.

Msp1 can destabilize the hyphae of C. albicans.

Learn More about Our Design

Practices Facilitated Our Project

Initially, we brainstormed to decide our project. We came up with three projects: General White Resistance, Vaginitis Treatment and Plant Resistance Improvement
After attending the women's lecture, we decided to study the method of treating vaginitis and confirmed VVC through questionnaire collection.
After interviewing patients and doctors, we learned about the current problems in the treatment of VVC and brainstormed the project 1.0.
After having brainstormed project 1.0.We interviewed professors give us suggestions to improve our project 1.0 and obtained project 2.0.
We interviewed experts for a comprehensive assessment of our project. To make project practical, we interviewed ethical experts, pharmacies and pharmacies.

Model

Our project is well conducted by Model in terms of experiments and prediction of future application. Our Model is constituted with

1. C. albicans Sensing Model
2. Gene Concentration Prediction Model
3. Market Prediction Model

Learn More about Our Model

In Case You Missed Them:

Background

Design

Result

Our Parts

Practices

Medals