DNA is a biological macro-molecule which can carry huge amount of information accurately, and this feature can be used to achieve data recordings in vivo. Our project aims to build a biological recorder that can monitor extracellular information and record it on DNA. Recombinase or CRISPR base-editor is used to target specific DNA addresses and generate mutations in a reporter gene, so the recordings can be quantitatively measured to infer intensity and duration information about the chemicals of disease, such as inflammatory bowel disease. Additionally, we designed a hardware for in situ biomolecular detection to monitor gastrointestinal health. This platform could enable more precise detection and could help improve the management and diagnosis of gastrointestinal disease.
Our Star Designs!
Integrated Human Practices
It helps us to optimize our design and make our project more practical and accurate. We visited and investigated two hospitals, one pharmaceutical factory, took part in CCIC and interacted with BNU.
In order to educate and introduce synthetic biology to students, we set up the SHSBNU_China Synthetic Biology Club. In the meanwhile, we created videos about some intriguing experiments to attract students.
For the container for the bacteria, we designed a capsule using environment-friendly materials. Patients can easily use the kit to get a qualitative result. The detailed design of the capsule is shown in the hardware page.