Difference between revisions of "Team:Tuebingen/landing animation"

(Created page with "<html lang="en" dir="ltr" class="client-nojs"> <meta charset="UTF-8" content="width=device-width, initial-scale=1.0"/> <style> /*! * Bootstrap v4.1.0 (https://getbootstr...")
 
 
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         Your browser does not support HTML5 video.
 
         Your browser does not support HTML5 video.
 
     </video>
 
     </video>
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    <div class="text-light d-flex flex-column justify-content-center ml-auto mr-auto"
+
 
−
        style="position: absolute; bottom:30vh; width: 100%; padding: 50px;">
+
−
        <div id="goToBox" class="mt-5">
+
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            <a id="goTo" href="#whyTitle">
+
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                <div class="chevron"></div>
+
−
                <div class="chevron"></div>
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                <div class="chevron"></div>
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−
            </a>
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        </div>
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−
    </div>
+
 
</div>
 
</div>
  
  
−
<div id="whyTitle" class="container-fluid jumbotron jumbotron-fluid text-center mb-0 p-0 align-items-center text-light">
+
<div id="whyTitle" class="container-fluid jumbotron jumbotron-fluid text-center mb-0 p-0 align-items-center text-light" style="overflow-x: hidden; overflow-y: hidden; font-family: 'Righteous'">
−
 
+
<div data-aos="zoom-out-left"
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    <div class="row pt-5 pb-3 ">
+
−
        <div class="warningContent col-12" data-aos="fade-up"
+
 
     data-aos-offset="200"
 
     data-aos-offset="200"
 
     data-aos-delay="50"
 
     data-aos-delay="50"
−
     data-aos-duration="1000"
+
     data-aos-duration="2000"
−
     data-aos-easing="ease-in-out"
+
     data-aos-easing="ease-in-out-cubic"
 
     data-aos-mirror="true"
 
     data-aos-mirror="true"
−
     data-aos-once="true">
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     data-aos-once="false">
 +
    <div class="row pt-5 pb-3 ">
 +
        <div class="warningContent col-12">
 
             <span class="align-middle">GLP.exe - a cheap and safe treatment for diabetes mellitus type 2</span>
 
             <span class="align-middle">GLP.exe - a cheap and safe treatment for diabetes mellitus type 2</span>
 
         </div>
 
         </div>
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     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
−
         <div class="col-12 col-md-6" data-aos="fade-up"
+
         <div class="col-12 col-md-6">
−
    data-aos-offset="200"
+
−
    data-aos-delay="50"
+
−
    data-aos-duration="1000"
+
−
    data-aos-easing="ease-in-out"
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−
    data-aos-mirror="true"
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−
    data-aos-once="false">
+
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif"
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif"
 
                 alt="meetUp" style="padding-left: 6vw;">
 
                 alt="meetUp" style="padding-left: 6vw;">
 
         </div>
 
         </div>
−
         <div class="col-12 col-md-6 slide-in pt-3" style="padding-right: 6vw;">
+
         <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;">
−
             <p class="text-justify text-phactory2 mobileText">Several treatment options for type 2 diabetes mellitus
+
             <p class="text-justify mobileText">Several treatment options for type 2 diabetes mellitus
 
                 have been developed in recent years.
 
                 have been developed in recent years.
 
             </p>
 
             </p>
  
−
             <p class="text-justify text-phactory2 mobileText">
+
             <p class="text-justify mobileText">
 
                 Hence, the diagnosis of type 2 diabetes mellitus is no longer a death sentence.
 
                 Hence, the diagnosis of type 2 diabetes mellitus is no longer a death sentence.
 
             </p>
 
             </p>
 
         </div>
 
         </div>
 
     </div>
 
     </div>
 +
</div>
  
 
     <div class="row pt-5 pb-3 ">
 
     <div class="row pt-5 pb-3 ">
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     </div>
 
     </div>
  
 +
    <div data-aos="zoom-out-right"
 +
    data-aos-offset="200"
 +
    data-aos-delay="50"
 +
    data-aos-duration="2000"
 +
    data-aos-easing="ease-in-out-cubic"
 +
    data-aos-mirror="true"
 +
    data-aos-once="false">
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
−
         <div class="col-12 col-md-6 slide-in">
+
         <div class="col-12 col-md-6">
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif"
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif"
 
                 alt="meetUp" style="padding-left: 6vw;">
 
                 alt="meetUp" style="padding-left: 6vw;">
 
         </div>
 
         </div>
  
−
         <div class="col-12 col-md-6 slide-in pt-3" style="padding-right: 6vw;">
+
         <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;">
−
             <h2 class="text-phactory2 display-4 mobileTitle">Current Drugs</h2>
+
             <h2 class="display-4 mobileTitle">Current Drugs</h2>
−
             <p class="text-justify text-phactory2 mobileText">...are expensive, require fine tuning and daily shots.
+
             <p class="text-justify mobileText">...are expensive, require fine tuning and daily shots.
 
                 Moreover, they have severe side-effects, causing patients to skip doses.</p>
 
                 Moreover, they have severe side-effects, causing patients to skip doses.</p>
  
−
             <p class="text-justify text-phactory2 mobileText">“Many patients don’t want to use insulin. They don’t want
+
             <p class="text-justify mobileText">“Many patients don’t want to use insulin. They don’t want
 
                 to do finger sticks and they’re afraid of hypoglycemia.”<br>
 
                 to do finger sticks and they’re afraid of hypoglycemia.”<br>
 
             </p>
 
             </p>
  
−
             <p class="text-justify text-phactory2 mobileText">
+
             <p class="text-justify mobileText">
 
                 “To fight the global diabetes pandemic, we would ideally have an accessible cost-effective
 
                 “To fight the global diabetes pandemic, we would ideally have an accessible cost-effective
 
                 easily-compliant intervention that has high clinical efficacy and that is free of adverse side effects.”<br><br>
 
                 easily-compliant intervention that has high clinical efficacy and that is free of adverse side effects.”<br><br>
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             </p>
 
             </p>
 
         </div>
 
         </div>
 +
    </div>
 
     </div>
 
     </div>
  
 
     <div class="row pt-5 pb-3 ">
 
     <div class="row pt-5 pb-3 ">
−
         <div class="warningContent col-12 slide-in">
+
         <div class="warningContent col-12">
 
             <span class="align-middle">However...</span>
 
             <span class="align-middle">However...</span>
 
         </div>
 
         </div>
 
     </div>
 
     </div>
 +
 +
    <div data-aos="zoom-out-left"
 +
    data-aos-offset="200"
 +
    data-aos-delay="50"
 +
    data-aos-duration="2000"
 +
    data-aos-easing="ease-in-out-cubic"
 +
    data-aos-mirror="true"
 +
    data-aos-once="false">
  
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
−
         <div class="col-12 col-md-6 slide-in">
+
         <div class="col-12 col-md-6">
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif"
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif"
 
                 alt="meetUp" style="padding-left: 6vw;">
 
                 alt="meetUp" style="padding-left: 6vw;">
 
         </div>
 
         </div>
  
−
         <div class="col-12 col-md-6 slide-in pt-3" style="padding-right: 6vw;">
+
         <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;">
−
             <h2 class="text-phactory2 display-4 mobileTitle">There's a solution!</h2>
+
             <h2 class="display-4 mobileTitle">There's a solution!</h2>
−
             <p class="text-justify text-phactory2 mobileText">Our therapeutic agent is a probiotic secreting incretin
+
             <p class="text-justify mobileText">Our therapeutic agent is a probiotic secreting incretin
 
                 mimetics placed in the patients intestine by oral administration of capsules. GLP-1 and Exendin-4, our
 
                 mimetics placed in the patients intestine by oral administration of capsules. GLP-1 and Exendin-4, our
 
                 main actors, cause an increase in insulin secretion, if the cell has already taken up sugar.</p>
 
                 main actors, cause an increase in insulin secretion, if the cell has already taken up sugar.</p>
  
−
             <p class="text-justify text-phactory2 mobileText">This enables an easier therapy where a regular intake of
+
             <p class="text-justify mobileText">This enables an easier therapy where a regular intake of
 
                 medicals are not required.</p>
 
                 medicals are not required.</p>
  
−
             <p class="text-justify text-phactory2 mobileText">Improved cell penetrating peptides with the use of
+
             <p class="text-justify mobileText">Improved cell penetrating peptides with the use of
 
                 artificial intelligence allow for an efficient and safe transport of our effectors into the cells.</p>
 
                 artificial intelligence allow for an efficient and safe transport of our effectors into the cells.</p>
 
         </div>
 
         </div>
 +
    </div>
 
     </div>
 
     </div>
  
 
     <div class="row pt-5 pb-3 ">
 
     <div class="row pt-5 pb-3 ">
−
         <div class="warningContent col-12 slide-in">
+
         <div class="warningContent col-12">
 
             <span class="align-middle">Safety</span>
 
             <span class="align-middle">Safety</span>
 
         </div>
 
         </div>
 
     </div>
 
     </div>
 +
 +
    <div data-aos="zoom-out-right"
 +
    data-aos-offset="200"
 +
    data-aos-delay="50"
 +
    data-aos-duration="2000"
 +
    data-aos-easing="ease-in-out-cubic"
 +
    data-aos-mirror="true"
 +
    data-aos-once="false">
  
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
−
         <div class="col-12 col-md-6 slide-in">
+
         <div class="col-12 col-md-6">
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/8/8b/T--Tuebingen--dna_gif.gif"
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/8/8b/T--Tuebingen--dna_gif.gif"
 
                 alt="meetUp" style="padding-left: 6vw;">
 
                 alt="meetUp" style="padding-left: 6vw;">
 
         </div>
 
         </div>
  
−
         <div class="col-12 col-md-6 slide-in pt-3" style="padding-right: 6vw;">
+
         <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;">
−
             <h2 class="text-phactory2 display-4 mobileTitle">is our highest priority!</h2>
+
             <h2 class="display-4 mobileTitle">is our highest priority!</h2>
−
             <p class="text-justify text-phactory2 mobileText">Therefore, we developed a novel, Cas3 based kill-switch
+
             <p class="text-justify mobileText">Therefore, we developed a novel, Cas3 based kill-switch
 
                 mechanism. The flexible system uses three regulators inspired by the human intestines: temperature,
 
                 mechanism. The flexible system uses three regulators inspired by the human intestines: temperature,
 
                 availability of fatty acids in form of Acyl CoA and N-Acetyl-Glucosamin. </p>
 
                 availability of fatty acids in form of Acyl CoA and N-Acetyl-Glucosamin. </p>
  
−
             <p class="text-justify text-phactory2 mobileText">
+
             <p class="text-justify mobileText">
 
                 If the conditions of our regulatory system are no longer met, Cas3 will be degrading all genetic
 
                 If the conditions of our regulatory system are no longer met, Cas3 will be degrading all genetic
 
                 information.
 
                 information.
 
             </p>
 
             </p>
 
         </div>
 
         </div>
 +
    </div>
 
     </div>
 
     </div>
  
 
     <div class="row pt-5 pb-3 ">
 
     <div class="row pt-5 pb-3 ">
−
         <div class="warningContent col-12 slide-in">
+
         <div class="warningContent col-12">
 
             <span class="align-middle">Additionally</span>
 
             <span class="align-middle">Additionally</span>
 
         </div>
 
         </div>
 
     </div>
 
     </div>
 +
 +
    <div data-aos="zoom-out-left"
 +
    data-aos-offset="200"
 +
    data-aos-delay="50"
 +
    data-aos-duration="2000"
 +
    data-aos-easing="ease-in-out-cubic"
 +
    data-aos-mirror="true"
 +
    data-aos-once="false">
  
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
−
         <div class="col-12 col-md-6 slide-in">
+
         <div class="col-12 col-md-6">
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/5/52/T--Tuebingen--interaction_gif.gif"
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/5/52/T--Tuebingen--interaction_gif.gif"
 
                 alt="meetUp" style="padding-left: 6vw;">
 
                 alt="meetUp" style="padding-left: 6vw;">
 
         </div>
 
         </div>
  
−
         <div class="col-12 col-md-6 slide-in pt-3" style="padding-right: 6vw;">
+
         <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;">
−
             <h2 class="text-phactory2 display-4 mobileTitle">An in depth E.coli Nissle characterization.</h2>
+
             <h2 class="display-4 mobileTitle" style="overflow-x: visible">An in depth E.coli Nissle characterization.</h2>
−
             <p class="text-justify text-phactory2 mobileText">Despite the fact that E. Coli Nissle is an alreasdy
+
             <p class="text-justify mobileText">Despite the fact that E. Coli Nissle is an alreasdy
 
                 approved probiotic, it's surprisingly badly characterized.</p>
 
                 approved probiotic, it's surprisingly badly characterized.</p>
  
−
             <p class="text-justify text-phactory2 mobileText">
+
             <p class="text-justify mobileText">
 
                 Hence, we provide the first metabolic model of E. coli Nissle and optimize it's growth for various
 
                 Hence, we provide the first metabolic model of E. coli Nissle and optimize it's growth for various
 
                 growth media. Furthermore, we predicted the interaction and competition of E. coli Nissle with common
 
                 growth media. Furthermore, we predicted the interaction and competition of E. coli Nissle with common
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             </p>
 
             </p>
  
−
             <p class="text-justify text-phactory2 mobileText">
+
             <p class="text-justify mobileText">
 
                 Finally, we carried out a series of RNA-Seq experiments to assess the adaptions and reactions of E. coli
 
                 Finally, we carried out a series of RNA-Seq experiments to assess the adaptions and reactions of E. coli
 
                 Nissle to aerob, as well as anaerob occuring stress factors.
 
                 Nissle to aerob, as well as anaerob occuring stress factors.
 
             </p>
 
             </p>
 
         </div>
 
         </div>
 +
    </div>
 
     </div>
 
     </div>
  
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         </div>
 
         </div>
 
     </div>
 
     </div>
 +
 +
    <div data-aos="zoom-out-right"
 +
    data-aos-offset="200"
 +
    data-aos-delay="50"
 +
    data-aos-duration="2000"
 +
    data-aos-easing="ease-in-out-cubic"
 +
    data-aos-mirror="true"
 +
    data-aos-once="false">
  
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
 
     <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;">
−
         <div class="col-12 col-md-6 slide-in">
+
         <div class="col-12 col-md-6">
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif"
 
             <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif"
 
                 alt="meetUp" style="padding-left: 6vw;">
 
                 alt="meetUp" style="padding-left: 6vw;">
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−
         <div class="col-12 col-md-6 slide-in pt-3" style="padding-right: 6vw;">
+
         <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;">
−
             <h2 class="text-phactory2 display-4 mobileTitle">Our work lays the foundation for an innovative, unprecedented approach to treat diabetes mellitus type 2.</h2>
+
             <h2 class="display-4 mobileTitle">Our work lays the foundation for an innovative, unprecedented approach to treat diabetes mellitus type 2.</h2>
 
         </div>
 
         </div>
 
     </div>
 
     </div>
 +
</div>
 
</div>
 
</div>
  
  
  
−
<div class='container-fluid p-3'>
+
<div class='container-fluid p-3' style="background-color: rgba(255, 255, 255, 0.3);">
−
    <hr>
+
        <hr>
−
    <div class='row align-items-center'>
+
        <div class='row align-items-center'>
−
        <div class='col-6 col-md-2 sponsorLogo'>
+
            <div class='col-6 col-md-2 sponsorLogo text-center'>
−
             <a href="https://www.embl.de/" target="_blank2"><img class="img-fluid"
+
                <a href="https://www.stura-tuebingen.de/" target="_blank2"><img class="img-fluid"
−
                                                                src="https://2019.igem.org/wiki/images/c/c4/T--Tuebingen--embl_logo.png"
+
                                                                                src="https://2019.igem.org/wiki/images/1/10/T--Tuebingen--stura_logo.png"
−
                                                                style="max-height: 70px;"></a>
+
                                                                                style="max-height: 80px;"></a>
−
        </div>
+
             </div>
−
        <div class='col-6 col-md-2 sponsorLogo'>
+
            <div class='col-6 col-md-2 sponsorLogo text-center'>
−
            <a href="https://www.stura-tuebingen.de/" target="_blank2"><img class="img-fluid"
+
                <a href="https://www.embl.de/" target="_blank2"><img class="img-fluid"
−
                                                                            src="https://2019.igem.org/wiki/images/1/10/T--Tuebingen--stura_logo.png"
+
                                                                    src="https://2019.igem.org/wiki/images/c/c4/T--Tuebingen--embl_logo.png"
−
                                                                            style="max-height: 70px;"></a>
+
                                                                    style="max-height: 80px;"></a>
−
        </div>
+
            </div>
−
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            <div class='col-6 col-md-2 sponsorLogo text-center'>
−
            <a href="https://www.zmbp.uni-tuebingen.de/zmbp.html" target="_blank2"><img class="img-fluid"
+
                <a href="https://www.kohlbacherlab.org" target="_blank2"><img class="img-fluid"
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                                                                                        src="https://2019.igem.org/wiki/images/d/d8/T--Tuebingen--zmbp_logo.png"
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        <div class='col-6 col-md-2 sponsorLogo'>
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            <a href="https://www.experimenta.science/en/" target="_blank2"><img class="img-fluid"
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                <a href="https://www.dieter-schwarz-stiftung.de/homepage.html" target="_blank2"><img class="img-fluid"
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            <a href="https://www.kohlbacherlab.org" target="_blank2"><img class="img-fluid"
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                <a href="https://www.experimenta.science/en/" target="_blank2"><img class="img-fluid"
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+
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+
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                <a href="https://www.zmbp.uni-tuebingen.de/zmbp.html" target="_blank2"><img class="img-fluid"
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                                                                                            src="https://2019.igem.org/wiki/images/d/d8/T--Tuebingen--zmbp_logo.png"
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</div>
 
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-->
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−
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                <a href="https://www.lexogen.com/" target="_blank2"><img class="img-fluid"
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                                                                    src="https://2019.igem.org/wiki/images/4/43/T--Tuebingen--lexogen_logo.png"></a>
+
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 +
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                <a href="https://www.agilent.com/" target="_blank2"><img class="img-fluid"
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                <a href="https://www.digitalocean.com/" target="_blank2"><img class="img-fluid"
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 +
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                <a href="https://www.eppendorf.com/" target="_blank2"><img class="img-fluid"
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 +
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                <a href="https://www.implen.de/" target="_blank2"><img class="img-fluid"
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 +
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                <a href="https://www.jenabioscience.com/" target="_blank2"><img class="img-fluid"
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 +
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                <a href="https://www.gbo.com/" target="_blank2"><img class="img-fluid"
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                <a href="http://www.metabion.com/" target="_blank2"><img class="img-fluid"
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 +
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                <a href="https://www.neb.com/" target="_blank2"><img class="img-fluid"
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−
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−
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−
        <div class='col-4 col-md-2 col-xl-1 sponsorLogo'>
 
−
            <a href="https://www.agilent.com/" target="_blank2"><img class="img-fluid"
 
−
                                                                    src="https://2019.igem.org/wiki/images/e/e7/T--Tuebingen--agilent_logo.png"></a>
 
−
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−
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−
            <a href="https://www.digitalocean.com/" target="_blank2"><img class="img-fluid"
 
−
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−
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−
        <div class='col-4 col-md-2 col-xl-1 sponsorLogo'>
 
−
            <a href="https://dwk.com/" target="_blank2"><img class="img-fluid"
 
−
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−
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−
        <div class='col-4 col-md-2 col-xl-1 sponsorLogo'>
 
−
            <a href="https://www.eppendorf.com/" target="_blank2"><img class="img-fluid"
 
−
                                                                      src="https://2019.igem.org/wiki/images/a/a6/T--Tuebingen--eppendorf_logo.png"></a>
 
−
        </div>
 
−
        <div class='col-4 col-md-2 col-xl-1 sponsorLogo'>
 
−
            <a href="https://www.implen.de/" target="_blank2"><img class="img-fluid"
 
−
                                                                  src="https://2019.igem.org/wiki/images/f/f1/T--Tuebingen--implem_logo.png"></a>
 
−
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−
        <div class='col-4 col-md-2 col-xl-1 sponsorLogo'>
 
−
            <a href="https://www.jenabioscience.com/" target="_blank2"><img class="img-fluid"
 
−
                                                                            src="https://2019.igem.org/wiki/images/3/31/T--Tuebingen--JBS_logo.png"></a>
 
−
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−
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−
            <a href="https://www.gbo.com/" target="_blank2"><img class="img-fluid"
 
−
                                                                src="https://2019.igem.org/wiki/images/a/ae/T--Tuebingen--greiner_logo.png"></a>
 
−
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−
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−
            <a href="http://www.metabion.com/" target="_blank2"><img class="img-fluid"
 
−
                                                                    src="https://2019.igem.org/wiki/images/8/88/T--Tuebingen--metabion_logo.png"></a>
 
−
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−
        <div class='col-4 col-md-2 col-xl-1 sponsorLogo'>
 
−
            <a href="https://www.microsynth.ch/home-ch.html" target="_blank2"><img class="img-fluid"
 
−
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−
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−
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−
            <a href="https://www.neb.com/" target="_blank2"><img class="img-fluid"
 
−
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−
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−
    </div>
 
  
−
    <div class='row align-items-center'>
+
        <div class='row align-items-center'>
−
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−
            <a href="https://www.promega.de/en/" target="_blank2"><img class="img-fluid"
+
                <a href="https://www.promega.de/en/" target="_blank2"><img class="img-fluid"
−
                                                                      src="https://2019.igem.org/wiki/images/f/f8/T--Tuebingen--promega_logo.png"></a>
+
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 +
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 +
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 +
                <a href="https://www.qiagen.com/us/" target="_blank2"><img class="img-fluid"
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 +
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 +
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 +
                <a href="https://www.carlroth.com/en/en" target="_blank2"><img class="img-fluid"
 +
                                                                              src="https://2019.igem.org/wiki/images/6/61/T--Tuebingen--roth_logo.png"></a>
 +
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 +
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 +
                <a href="https://www.sitoolsbiotech.com/" target="_blank2"><img class="img-fluid"
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 +
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 +
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 +
                <a href="https://www.snapgene.com/" target="_blank2"><img class="img-fluid"
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 +
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 +
            <div class='col-4 col-md-2 col-xl-1 sponsorLogo text-center'>
 +
                <a href="https://www.trilinkbiotech.com/" target="_blank2"><img class="img-fluid"
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 +
            </div>
 +
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 +
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 +
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 +
                <a href="http://www.vazymebiotech.com/" target="_blank2"><img class="img-fluid"
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 +
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            <div class='col-4 col-md-2 col-xl-1 sponsorLogo text-center'>
 +
                <a href="https://www.biolegend.com/" target="_blank2"><img class="img-fluid"
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 +
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 +
                <a href="https://www.zymoresearch.de/" target="_blank2"><img class="img-fluid"
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 +
            </div>
 +
 
 
         </div>
 
         </div>
−
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−
            <a href="https://www.qiagen.com/us/" target="_blank2"><img class="img-fluid"
 
−
                                                                      src="https://2019.igem.org/wiki/images/9/92/T--Tuebingen--qiagen_logo.png"></a>
 
−
        </div>
 
−
        <div class='col-4 col-md-2 col-xl-1 sponsorLogo'>
 
−
            <a href="https://www.carlroth.com/en/en" target="_blank2"><img class="img-fluid"
 
−
                                                                          src="https://2019.igem.org/wiki/images/6/61/T--Tuebingen--roth_logo.png"></a>
 
−
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−
        <div class='col-4 col-md-2 col-xl-1 sponsorLogo'>
 
−
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Latest revision as of 14:56, 12 October 2019

GLP.exe

GLP.exe - a cheap and safe treatment for diabetes mellitus type 2
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Several treatment options for type 2 diabetes mellitus have been developed in recent years.

Hence, the diagnosis of type 2 diabetes mellitus is no longer a death sentence.

yet...
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Current Drugs

...are expensive, require fine tuning and daily shots. Moreover, they have severe side-effects, causing patients to skip doses.

“Many patients don’t want to use insulin. They don’t want to do finger sticks and they’re afraid of hypoglycemia.”

“To fight the global diabetes pandemic, we would ideally have an accessible cost-effective easily-compliant intervention that has high clinical efficacy and that is free of adverse side effects.”

Prof. Harold Lebovitz, State University of New York Health Science Center, Brooklyn, New York

However...
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There's a solution!

Our therapeutic agent is a probiotic secreting incretin mimetics placed in the patients intestine by oral administration of capsules. GLP-1 and Exendin-4, our main actors, cause an increase in insulin secretion, if the cell has already taken up sugar.

This enables an easier therapy where a regular intake of medicals are not required.

Improved cell penetrating peptides with the use of artificial intelligence allow for an efficient and safe transport of our effectors into the cells.

Safety
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is our highest priority!

Therefore, we developed a novel, Cas3 based kill-switch mechanism. The flexible system uses three regulators inspired by the human intestines: temperature, availability of fatty acids in form of Acyl CoA and N-Acetyl-Glucosamin.

If the conditions of our regulatory system are no longer met, Cas3 will be degrading all genetic information.

Additionally
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An in depth E.coli Nissle characterization.

Despite the fact that E. Coli Nissle is an alreasdy approved probiotic, it's surprisingly badly characterized.

Hence, we provide the first metabolic model of E. coli Nissle and optimize it's growth for various growth media. Furthermore, we predicted the interaction and competition of E. coli Nissle with common competitors for various fluxes.

Finally, we carried out a series of RNA-Seq experiments to assess the adaptions and reactions of E. coli Nissle to aerob, as well as anaerob occuring stress factors.

Bringing it all together
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Our work lays the foundation for an innovative, unprecedented approach to treat diabetes mellitus type 2.