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Your browser does not support HTML5 video. | Your browser does not support HTML5 video. | ||
</video> | </video> | ||
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</div> | </div> | ||
| − | <div id="whyTitle" class="container-fluid jumbotron jumbotron-fluid text-center mb-0 p-0 align-items-center text-light" | + | <div id="whyTitle" class="container-fluid jumbotron jumbotron-fluid text-center mb-0 p-0 align-items-center text-light" style="overflow-x: hidden"> |
| − | + | <div data-aos="zoom-out-left" | |
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data-aos-offset="200" | data-aos-offset="200" | ||
data-aos-delay="50" | data-aos-delay="50" | ||
| − | data-aos-duration=" | + | data-aos-duration="3000" |
| − | data-aos-easing="ease-in-out" | + | data-aos-easing="ease-in-out-cubic" |
data-aos-mirror="true" | data-aos-mirror="true" | ||
| − | data-aos-once=" | + | data-aos-once="false"> |
| + | <div class="row pt-5 pb-3 "> | ||
| + | <div class="warningContent col-12"> | ||
<span class="align-middle">GLP.exe - a cheap and safe treatment for diabetes mellitus type 2</span> | <span class="align-middle">GLP.exe - a cheap and safe treatment for diabetes mellitus type 2</span> | ||
</div> | </div> | ||
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<div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6"> |
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<img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif" | <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif" | ||
alt="meetUp" style="padding-left: 6vw;"> | alt="meetUp" style="padding-left: 6vw;"> | ||
</div> | </div> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;"> |
| − | <p class="text-justify | + | <p class="text-justify mobileText">Several treatment options for type 2 diabetes mellitus |
have been developed in recent years. | have been developed in recent years. | ||
</p> | </p> | ||
| − | <p class="text-justify | + | <p class="text-justify mobileText"> |
Hence, the diagnosis of type 2 diabetes mellitus is no longer a death sentence. | Hence, the diagnosis of type 2 diabetes mellitus is no longer a death sentence. | ||
</p> | </p> | ||
</div> | </div> | ||
</div> | </div> | ||
| + | </div> | ||
<div class="row pt-5 pb-3 "> | <div class="row pt-5 pb-3 "> | ||
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</div> | </div> | ||
| + | <div data-aos="fade-left" | ||
| + | data-aos-offset="200" | ||
| + | data-aos-delay="50" | ||
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| + | data-aos-mirror="true" | ||
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<div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6"> |
<img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif" | <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif" | ||
alt="meetUp" style="padding-left: 6vw;"> | alt="meetUp" style="padding-left: 6vw;"> | ||
</div> | </div> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;"> |
<h2 class="text-phactory2 display-4 mobileTitle">Current Drugs</h2> | <h2 class="text-phactory2 display-4 mobileTitle">Current Drugs</h2> | ||
<p class="text-justify text-phactory2 mobileText">...are expensive, require fine tuning and daily shots. | <p class="text-justify text-phactory2 mobileText">...are expensive, require fine tuning and daily shots. | ||
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</p> | </p> | ||
</div> | </div> | ||
| + | </div> | ||
</div> | </div> | ||
<div class="row pt-5 pb-3 "> | <div class="row pt-5 pb-3 "> | ||
| − | <div class="warningContent col-12 | + | <div class="warningContent col-12"> |
<span class="align-middle">However...</span> | <span class="align-middle">However...</span> | ||
</div> | </div> | ||
</div> | </div> | ||
| + | |||
| + | <div data-aos="zoom-in-left" | ||
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<div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6"> |
<img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif" | <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif" | ||
alt="meetUp" style="padding-left: 6vw;"> | alt="meetUp" style="padding-left: 6vw;"> | ||
</div> | </div> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;"> |
<h2 class="text-phactory2 display-4 mobileTitle">There's a solution!</h2> | <h2 class="text-phactory2 display-4 mobileTitle">There's a solution!</h2> | ||
<p class="text-justify text-phactory2 mobileText">Our therapeutic agent is a probiotic secreting incretin | <p class="text-justify text-phactory2 mobileText">Our therapeutic agent is a probiotic secreting incretin | ||
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artificial intelligence allow for an efficient and safe transport of our effectors into the cells.</p> | artificial intelligence allow for an efficient and safe transport of our effectors into the cells.</p> | ||
</div> | </div> | ||
| + | </div> | ||
</div> | </div> | ||
<div class="row pt-5 pb-3 "> | <div class="row pt-5 pb-3 "> | ||
| − | <div class="warningContent col-12 | + | <div class="warningContent col-12"> |
<span class="align-middle">Safety</span> | <span class="align-middle">Safety</span> | ||
</div> | </div> | ||
</div> | </div> | ||
| + | |||
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<div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6"> |
<img class="img-fluid" src="https://2019.igem.org/wiki/images/8/8b/T--Tuebingen--dna_gif.gif" | <img class="img-fluid" src="https://2019.igem.org/wiki/images/8/8b/T--Tuebingen--dna_gif.gif" | ||
alt="meetUp" style="padding-left: 6vw;"> | alt="meetUp" style="padding-left: 6vw;"> | ||
</div> | </div> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;"> |
<h2 class="text-phactory2 display-4 mobileTitle">is our highest priority!</h2> | <h2 class="text-phactory2 display-4 mobileTitle">is our highest priority!</h2> | ||
<p class="text-justify text-phactory2 mobileText">Therefore, we developed a novel, Cas3 based kill-switch | <p class="text-justify text-phactory2 mobileText">Therefore, we developed a novel, Cas3 based kill-switch | ||
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</p> | </p> | ||
</div> | </div> | ||
| + | </div> | ||
</div> | </div> | ||
<div class="row pt-5 pb-3 "> | <div class="row pt-5 pb-3 "> | ||
| − | <div class="warningContent col-12 | + | <div class="warningContent col-12"> |
<span class="align-middle">Additionally</span> | <span class="align-middle">Additionally</span> | ||
</div> | </div> | ||
</div> | </div> | ||
| + | |||
| + | <div data-aos="flip-left" | ||
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<div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6"> |
<img class="img-fluid" src="https://2019.igem.org/wiki/images/5/52/T--Tuebingen--interaction_gif.gif" | <img class="img-fluid" src="https://2019.igem.org/wiki/images/5/52/T--Tuebingen--interaction_gif.gif" | ||
alt="meetUp" style="padding-left: 6vw;"> | alt="meetUp" style="padding-left: 6vw;"> | ||
</div> | </div> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6 pt-3" style="padding-right: 6vw;"> |
<h2 class="text-phactory2 display-4 mobileTitle">An in depth E.coli Nissle characterization.</h2> | <h2 class="text-phactory2 display-4 mobileTitle">An in depth E.coli Nissle characterization.</h2> | ||
<p class="text-justify text-phactory2 mobileText">Despite the fact that E. Coli Nissle is an alreasdy | <p class="text-justify text-phactory2 mobileText">Despite the fact that E. Coli Nissle is an alreasdy | ||
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</p> | </p> | ||
</div> | </div> | ||
| + | </div> | ||
</div> | </div> | ||
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</div> | </div> | ||
</div> | </div> | ||
| + | |||
| + | <div data-aos="zoom-out-left" | ||
| + | data-aos-offset="200" | ||
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| + | data-aos-mirror="true" | ||
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<div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | <div class="row p-5" style="padding-left: 10vw; padding-right: 10vw;"> | ||
| − | <div class="col-12 col-md-6 | + | <div class="col-12 col-md-6"> |
<img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif" | <img class="img-fluid" src="https://2019.igem.org/wiki/images/f/f0/T--Tuebingen--nissle_gif.gif" | ||
alt="meetUp" style="padding-left: 6vw;"> | alt="meetUp" style="padding-left: 6vw;"> | ||
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<h2 class="text-phactory2 display-4 mobileTitle">Our work lays the foundation for an innovative, unprecedented approach to treat diabetes mellitus type 2.</h2> | <h2 class="text-phactory2 display-4 mobileTitle">Our work lays the foundation for an innovative, unprecedented approach to treat diabetes mellitus type 2.</h2> | ||
</div> | </div> | ||
</div> | </div> | ||
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| + | src="https://2019.igem.org/wiki/images/2/29/T--Tuebingen--neb_logo.png"></a> | ||
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Revision as of 13:54, 12 October 2019
Several treatment options for type 2 diabetes mellitus have been developed in recent years.
Hence, the diagnosis of type 2 diabetes mellitus is no longer a death sentence.
Current Drugs
...are expensive, require fine tuning and daily shots. Moreover, they have severe side-effects, causing patients to skip doses.
“Many patients don’t want to use insulin. They don’t want
to do finger sticks and they’re afraid of hypoglycemia.”
“To fight the global diabetes pandemic, we would ideally have an accessible cost-effective
easily-compliant intervention that has high clinical efficacy and that is free of adverse side effects.”
Prof. Harold Lebovitz, State University of New York Health Science Center, Brooklyn, New York
There's a solution!
Our therapeutic agent is a probiotic secreting incretin mimetics placed in the patients intestine by oral administration of capsules. GLP-1 and Exendin-4, our main actors, cause an increase in insulin secretion, if the cell has already taken up sugar.
This enables an easier therapy where a regular intake of medicals are not required.
Improved cell penetrating peptides with the use of artificial intelligence allow for an efficient and safe transport of our effectors into the cells.
is our highest priority!
Therefore, we developed a novel, Cas3 based kill-switch mechanism. The flexible system uses three regulators inspired by the human intestines: temperature, availability of fatty acids in form of Acyl CoA and N-Acetyl-Glucosamin.
If the conditions of our regulatory system are no longer met, Cas3 will be degrading all genetic information.
An in depth E.coli Nissle characterization.
Despite the fact that E. Coli Nissle is an alreasdy approved probiotic, it's surprisingly badly characterized.
Hence, we provide the first metabolic model of E. coli Nissle and optimize it's growth for various growth media. Furthermore, we predicted the interaction and competition of E. coli Nissle with common competitors for various fluxes.
Finally, we carried out a series of RNA-Seq experiments to assess the adaptions and reactions of E. coli Nissle to aerob, as well as anaerob occuring stress factors.



























