Difference between revisions of "Team:Pasteur Paris/test/Description"

m
Line 2,352: Line 2,352:
 
</p>
 
</p>
 
<br>
 
<br>
 +
 
<div id="nanotube_illustration" style="width: 60%;">
 
<div id="nanotube_illustration" style="width: 60%;">
−
<img id="nanotube_illustration_png" src="https://2019.igem.org/wiki/images/2/2d/T--Pasteur_Paris--aptamers_on_nanotube.png" style="width: 90%; margin-left: 35%">
+
<svg id="nanotube_illustration_svg" data-name="Calque 1" xmlns="http://www.w3.org/2000/svg"
−
</div>
+
−
<br>
+
  
−
<p id="device_Description_text" style="text-align: justify; font-size: 18px;">
+
      viewBox="0 0 706.9 272.4"><defs><linearGradient id="Dégradé_sans_nom_8" x1="27.6"
−
We will perform the SELEX (Systematic Evolution of Ligands By Exponential Enrichment) method to obtain these aptamers and with them build electrodes with high specificity.
+
−
</p>
+
−
<br>
+
  
−
<div id="nanotube_explanation">
+
          y1="141.7" x2="732" y2="141.7" gradientUnits="userSpaceOnUse"><stop offset="0"
−
<img id="nanotube_explanation_png" src="https://2019.igem.org/wiki/images/2/2f/T--Pasteur_Paris--aptamers_explanation.png" style="width: 70%; margin-left: 15%;">
+
−
</div>
+
−
<p id="device_Description_text" style="text-align: center; font-size: 15px;">
+
−
<i>Simplified operating principle for specific bacteria detection using a regular electrode and another one with our aptamers bound to carbon nanotubes.
+
−
</i>
+
−
<br>
+
−
<br>
+
  
−
<p id="device_Description_text" style="text-align: justify; font-size: 18px;">
+
            stop-color="#1a3a3a" stop-opacity=".4"></stop><stop offset="0" stop-color="#1a3a3a"
−
Simplified operating principle for specific bacteria detection using a regular electrode and another one with our aptamers bound to carbon nanotubes.
+
−
Our job will not settle for making a electrod-aptamers system capable of detecting and quantifying specific bacteria but it will also consist in the creation of an actual prototype capable of indicating which strain is responsible for the infection to a doctor, taking into account the user scenari, security, and the ethical responsibility linked to the device. We also aim at creating this device in such a way that it could be used in remote locations during humanitarian missions.
+
−
</p>
+
−
<br>
+
  
−
<p id="device_Description_refence_title" style="text-align: justify; font-size: 18px;">
+
            stop-opacity=".4"></stop><stop offset=".2" stop-color="#224c4c" stop-opacity=".6"></stop><stop
−
<b>References:</b>
+
−
</p>
+
−
<p id="device_Description_refence_title" style="text-align: justify; font-size: 18px;">
+
−
Gustavo A. Zelada-Guillén and al., “Immediate Detection of Living Bacteria at Ultralow Concentrations Using a Carbon Nanotube Based Potentiometric Aptasensor”, Angew. Chem. Int. Ed., 2009, vol 48, pages 7334 –7337
+
−
<br><br>
+
−
Kwame Sefah, Dihua Shangguan, Xiangling Xiong, Meghan B O’Donoghue & Weihong Tan, “Development of DNA aptamers using Cell-SELEX”, Nature Protocols, 2010, vol 5, pages 1169–1185
+
−
</p>
+
  
 +
            offset=".3" stop-color="#285959" stop-opacity=".8"></stop><stop offset=".5"
  
 +
            stop-color="#2c6363" stop-opacity=".9"></stop><stop offset=".7" stop-color="#2e6868"></stop><stop
  
 +
            offset="1" stop-color="#2f6a6a"></stop></linearGradient><clipPath id="clip-path"
  
−
<div style="width:30%;margin-left:40%;">
+
          transform="translate(-26.3 -7.5)"><rect class="desc3-1" x="129.8" y="63.7"
−
      <svg  viewBox="0 0 840.1 883.1">
+
−
        <defs><style>.NNTbe-1,.NNTbe-10,.NNTbe-11,.NNTbe-12,.NNTbe-3,.NNTbe-4,.NNTbe-5,.NNTbe-7,.NNTbe-8,.NNTbe-9{fill:none;}.NNTbe-1,.NNTbe-10,.NNTbe-11,.NNTbe-16,.NNTbe-2,.NNTbe-3,.NNTbe-4,.NNTbe-5,.NNTbe-7,.NNTbe-8{stroke:#fff;}.NNTbe-1,.NNTbe-10,.NNTbe-12,.NNTbe-16,.NNTbe-2,.NNTbe-3,.NNTbe-4,.NNTbe-5,.NNTbe-7,.NNTbe-8,.NNTbe-9{stroke-miterlimit:10;}.NNTbe-1,.NNTbe-12{stroke-width:2px;}.NNTbe-16,.NNTbe-2,.NNTbe-3{stroke-width:3px;}.NNTbe-2{fill:url(#Dégradé_sans_nom_149);}.NNTbe-10,.NNTbe-11,.NNTbe-4{stroke-linecap:round;}.NNTbe-4,.NNTbe-5{stroke-width:8px;}.NNTbe-6{clip-path:url(#clip-path);}.NNTbe-7,.NNTbe-9{stroke-width:7px;}.NNTbe-9{stroke:#2f6a6a;}.NNTbe-10{stroke-width:5px;}.NNTbe-11{stroke-linejoin:round;stroke-width:15px;}.NNTbe-12{stroke:#d9e021;}.NNTbe-13{opacity:0.9;}.NNTbe-14,.NNTbe-15,.NNTbe-16{fill:#fff;}.NNTbe-15{font-size:150px;font-family:Lato-Light,
+
−
            Lato Light;}</style><linearGradient id="Dégradé_sans_nom_149" x1="53.73"
+
  
−
             y1="706.34" x2="890.81" y2="706.34" gradientUnits="userSpaceOnUse"><stop
+
             width="49.8" height="168.1" rx="24.9"></rect></clipPath><style>.desc3-1,.desc3-2,.desc3-6,.desc3-7,.desc3-8,.desc3-9{fill:none}.desc3-1,.desc3-2,.desc3-6,.desc3-7{stroke:#fff}.desc3-1,.desc3-2,.desc3-6,.desc3-7,.desc3-8,.desc3-9{stroke-miterlimit:10}.desc3-2{stroke-width:3px}.desc3-6,.desc3-8{stroke-width:7px}.desc3-7{stroke-width:2px}.desc3-8{stroke:#2f6a6a}.desc3-9{stroke:#d9e021}</style></defs><path
  
−
              offset="0" stop-color="#1a3a3a" stop-opacity="0.25"></stop><stop offset="0.52"
+
        d="M585.5 274.7H34.8c-4 0-7.2-6.4-7.2-10.3V16a7.2 7.2 0 017.3-7.2h690A7.2 7.2 0 01732 16v248.4c0 4-3.2 10.3-7.2 10.3h-67.2"
  
−
              stop-color="#245252" stop-opacity="0.62"></stop><stop offset="1" stop-color="#2f6a6a"></stop></linearGradient><clipPath
+
        transform="translate(-26.3 -7.5)" stroke-width="2.5" fill="url(#Dégradé_sans_nom_8)"
  
−
            id="clip-path" transform="translate(-52.2 -171.2)"><rect class="NNTbe-1"
+
        stroke-miterlimit="10" stroke="#fff"></path><circle cx="628.5" cy="267.1"
  
−
              x="500.1" y="694.4" width="82.9" height="280.22" rx="41.5" ry="41.5"></rect></clipPath></defs><title>explication
+
        r="3.8" fill="#fff" stroke-width="3" stroke-miterlimit="10" stroke="#fff"></circle><circle
−
          projet AVEC DEGRADE</title><path class="NNTbe-2" d="M878.8,359.8a12,12,0,0,1,12,12v669.1a12,12,0,0,1-12,12H65.7a12,12,0,0,1-12-12V371.8a12,12,0,0,1,12-12H772.3"
+
  
−
          transform="translate(-52.2 -171.2)"></path><path class="NNTbe-3" d="M410.4,531.6c0-32.5-27.5-58.8-61.4-58.8s-61.4,26.3-61.4,58.8c0,20.2,10.6,38,26.7,48.6v29.9a12.3,12.3,0,0,0,12.5,12h44.4a12.3,12.3,0,0,0,12.5-12V580.2C399.8,569.6,410.4,551.8,410.4,531.6Z"
+
        class="desc3-2" cx="563.9" cy="267.1" r="3.8"></circle><g clip-path="url(#clip-path)"><path
  
−
           transform="translate(-52.2 -171.2)"></path><rect class="NNTbe-3" x="267.9"
+
           class="desc3-1" d="M96.7 34.4h-5.5L88.5 39l2.7 4.8h5.5l2.7-4.8-2.7-4.7z"></path><path
  
−
           y="439" width="57.6" height="52.25" rx="12" ry="12"></rect><path class="NNTbe-3"
+
           class="desc3-6" d="M105 29.6h-5.5l-2.8 4.8 2.8 4.7h5.5l2.7-4.8-2.7-4.7z"></path><path
  
−
           d="M332.7,610.3V543.5l6,11.9,4.3-13.6,5.2,13.5,5.2-13.9,5.7,14.1,6.9-13.4c.3,4,0,68.2,0,68.2"
+
           class="desc3-1" d="M105 39.1h-5.5l-2.8 4.8 2.8 4.7h5.5l2.7-4.8-2.7-4.7zM113.2 34.4h-5.5L105 39l2.7 4.8h5.5l2.7-4.8-2.7-4.8zM113.2 43.9h-5.5l-2.7 4.7 2.7 4.8h5.5l2.7-4.8-2.7-4.8zM121.4 39.1H116l-2.7 4.8 2.7 4.7h5.5l2.8-4.8-2.8-4.7zM157.2 91.3h5.4l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
           transform="translate(-52.2 -171.2)"></path><path class="NNTbe-3" d="M379.1,628.5l-61.6,11.2a3.1,3.1,0,0,0-2.6,3.6h0a3.2,3.2,0,0,0,3.8,2.5l61.6-11.2a3.3,3.3,0,0,0,2.6-3.7h0A3.3,3.3,0,0,0,379.1,628.5Z"
+
           class="desc3-1" d="M148.9 96h5.5l2.7-4.7-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8zM148.9 86.6h5.5l2.7-4.8-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8z"></path><path
  
−
           transform="translate(-52.2 -171.2)"></path><path class="NNTbe-3" d="M377.3,614.4,318,625.2a3.2,3.2,0,0,0-2.6,3.6h0a3.3,3.3,0,0,0,3.8,2.5l59.3-10.8a3.1,3.1,0,0,0,2.6-3.6h0A3.2,3.2,0,0,0,377.3,614.4Z"
+
           class="desc3-1" d="M140.7 91.3h5.4l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7zM140.7 81.8h5.4l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
           transform="translate(-52.2 -171.2)"></path><path class="NNTbe-3" d="M379.6,643.2,318,654.4a3.3,3.3,0,0,0-2.6,3.7h0a3.4,3.4,0,0,0,3.8,2.4l61.6-11.2a3.1,3.1,0,0,0,2.6-3.6h0A3.2,3.2,0,0,0,379.6,643.2Z"
+
           class="desc3-1" d="M132.4 86.6h5.5l2.7-4.8-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8zM99.5 124.7h5.5l2.7-4.8-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8zM91.2 129.4h5.5l2.7-4.7-2.7-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
           transform="translate(-52.2 -171.2)"></path><line class="NNTbe-4" x1="364.3"
+
           class="desc3-1" d="M91.2 120h5.5l2.7-4.8-2.7-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
           y1="471.2" x2="489.3" y2="471.2"></line><line class="NNTbe-5" x1="489.3"
+
           class="desc3-1" d="M83 124.7h5.5l2.7-4.8-2.7-4.7H83l-2.8 4.7 2.8 4.8zM83 115.2h5.5l2.7-4.8-2.7-4.7H83l-2.8 4.7 2.8 4.8z"></path><path
  
−
           y1="523.2" x2="489.3" y2="471.2"></line><g class="NNTbe-6"><polygon class="NNTbe-1"
+
           class="desc3-1" d="M74.8 120h5.4l2.8-4.8-2.8-4.8h-5.5l-2.7 4.8 2.8 4.7zM116 143.6h5.4l2.8-4.8-2.8-4.7H116l-2.7 4.7 2.7 4.8zM107.7 148.3h5.5l2.7-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
            points="436.6 486.8 427.5 486.8 422.9 494.7 427.5 502.6 436.6 502.6 441.2 494.7 436.6 486.8"></polygon><polygon
+
          class="desc3-1" d="M107.7 138.8h5.5l2.7-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-7" points="450.4 478.8 441.3 478.8 436.7 486.8 441.3 494.7 450.4 494.7 455 486.8 450.4 478.8"></polygon><polygon
+
          class="desc3-1" d="M99.4 143.6h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="450.4 494.7 441.3 494.7 436.7 502.6 441.3 510.5 450.4 510.5 455 502.6 450.4 494.7"></polygon><polygon
+
          class="desc3-1" d="M99.4 134h5.5l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="464.1 486.8 455 486.8 450.4 494.7 455 502.6 464.1 502.6 468.7 494.7 464.1 486.8"></polygon><polygon
+
          class="desc3-1" d="M91.2 138.8h5.5l2.7-4.7-2.7-4.8h-5.5l-2.7 4.8 2.7 4.7zM113.2 129.3h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7zM121.4 134H116l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8zM121.4 124.6H116l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="464.1 502.6 455 502.6 450.4 510.5 455 518.4 464.1 518.4 468.7 510.5 464.1 502.6"></polygon><polygon
+
          class="desc3-1" d="M129.7 129.3h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7zM129.7 119.8h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7zM137.9 124.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8zM121.4 77H116l-2.7-4.7 2.7-4.7h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="477.8 494.7 468.7 494.7 464.1 502.6 468.7 510.5 477.8 510.5 482.4 502.6 477.8 494.7"></polygon><polygon
+
          class="desc3-1" d="M129.7 81.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="537.4 581.7 546.5 581.7 551.1 573.8 546.5 565.9 537.4 565.9 532.8 573.8 537.4 581.7"></polygon><polygon
+
          class="desc3-1" d="M129.7 72.3h-5.5l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="523.6 589.6 532.7 589.6 537.3 581.7 532.7 573.8 523.6 573.8 519 581.7 523.6 589.6"></polygon><polygon
+
          class="desc3-1" d="M138 77.1h-5.6l-2.7-4.8 2.8-4.7h5.4l2.8 4.8-2.8 4.7zM138 67.6h-5.6l-2.7-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="523.6 573.8 532.7 573.8 537.3 565.9 532.7 558 523.6 558 519 565.9 523.6 573.8"></polygon><polygon
+
          class="desc3-1" d="M146.2 72.3h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM113.3 100.8h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="509.9 581.7 519 581.7 523.6 573.8 519 565.9 509.9 565.9 505.3 573.8 509.9 581.7"></polygon><polygon
+
          class="desc3-1" d="M121.5 105.6H116l-2.7-4.8 2.7-4.7h5.5l2.8 4.8-2.8 4.7zM121.5 96.1H116l-2.7-4.8 2.7-4.7h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="509.9 565.9 519 565.9 523.6 558 519 550 509.9 550 505.3 558 509.9 565.9"></polygon><polygon
+
          class="desc3-1" d="M129.8 100.8h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="496.1 573.8 505.3 573.8 509.9 565.9 505.3 558 496.1 558 491.6 565.9 496.1 573.8"></polygon><polygon
+
          class="desc3-1" d="M129.8 91.3h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="441.3 637.3 450.4 637.3 455 629.4 450.4 621.5 441.3 621.5 436.7 629.4 441.3 637.3"></polygon><polygon
+
          class="desc3-1" d="M138 96.1h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.8L138 96zM91.3 100.8h5.5l2.7-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7zM83 105.6h5.5l2.7-4.8-2.7-4.7H83l-2.8 4.7 2.8 4.8zM83 96h5.5l2.7-4.7-2.7-4.7H83l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="427.5 645.2 436.6 645.2 441.2 637.3 436.6 629.4 427.5 629.4 422.9 637.3 427.5 645.2"></polygon><polygon
+
          class="desc3-1" d="M74.8 100.8h5.4l2.8-4.7-2.8-4.8h-5.4L72 96.1l2.8 4.7zM74.8 91.3h5.4l2.8-4.7-2.8-4.8h-5.4L72 86.6l2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="427.5 629.4 436.6 629.4 441.2 621.5 436.6 613.5 427.5 613.5 422.9 621.5 427.5 629.4"></polygon><polygon
+
          class="desc3-7" d="M66.5 96H72l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="413.8 637.3 422.9 637.3 427.5 629.4 422.9 621.5 413.8 621.5 409.2 629.4 413.8 637.3"></polygon><polygon
+
          class="desc3-1" d="M116 115h5.4l2.8-4.7-2.8-4.7H116l-2.7 4.7 2.7 4.8zM107.7 119.8h5.5l2.7-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="413.8 621.5 422.9 621.5 427.5 613.5 422.9 605.6 413.8 605.6 409.2 613.5 413.8 621.5"></polygon><polygon
+
          class="desc3-1" d="M107.7 110.3h5.5l2.7-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="400 629.4 409.2 629.4 413.7 621.5 409.2 613.5 400 613.5 395.5 621.5 400 629.4"></polygon><polygon
+
          class="desc3-1" d="M99.4 115.1h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.8 2.7 4.7zM99.4 105.6h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="468.7 668.8 477.8 668.8 482.4 660.9 477.8 653 468.7 653 464.1 660.9 468.7 668.8"></polygon><polygon
+
          class="desc3-1" d="M91.2 110.3h5.5l2.7-4.7-2.7-4.8h-5.5l-2.7 4.8 2.7 4.8zM96.7 91.5h-5.5l-2.7-4.8 2.8-4.7h5.4l2.8 4.7-2.8 4.8zM105 96.2h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="454.9 676.7 464 676.7 468.6 668.8 464 660.9 454.9 660.9 450.3 668.8 454.9 676.7"></polygon><polygon
+
          class="desc3-1" d="M105 86.7h-5.5L96.8 82l2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="454.9 660.9 464 660.9 468.6 653 464 645.1 454.9 645.1 450.3 653 454.9 660.9"></polygon><polygon
+
          class="desc3-1" d="M113.2 91.5h-5.5l-2.7-4.8 2.8-4.7h5.4l2.8 4.7-2.8 4.8zM113.2 82h-5.5l-2.7-4.8 2.8-4.7h5.4l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="441.2 668.8 450.3 668.8 454.9 660.9 450.3 653 441.2 653 436.6 660.9 441.2 668.8"></polygon><polygon
+
          class="desc3-1" d="M121.5 86.7H116l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM80.2 81.8h-5.5L72 77.1l2.8-4.8h5.4l2.8 4.8-2.8 4.7zM88.5 86.6H83l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8zM88.5 77H83l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="441.2 653 450.3 653 454.9 645.1 450.3 637.1 441.2 637.1 436.6 645.1 441.2 653"></polygon><polygon
+
          class="desc3-1" d="M96.7 81.8h-5.5l-2.7-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM96.7 72.3h-5.5l-2.7-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="427.5 660.9 436.6 660.9 441.2 653 436.6 645.1 427.5 645.1 422.9 653 427.5 660.9"></polygon><polygon
+
          class="desc3-1" d="M105 77h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM80.2 62.8h-5.5L72 58.1l2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="464 645.1 454.9 645.1 450.3 637.1 454.9 629.2 464 629.2 468.6 637.1 464 645.1"></polygon><polygon
+
          class="desc3-1" d="M88.5 67.6H83l-2.7-4.7L83 58h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="477.8 653 468.7 653 464.1 645.1 468.7 637.2 477.8 637.2 482.4 645.1 477.8 653"></polygon><polygon
+
          class="desc3-1" d="M88.5 58.1H83l-2.7-4.8 2.7-4.7h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="477.8 637.2 468.7 637.2 464.1 629.2 468.7 621.3 477.8 621.3 482.4 629.2 477.8 637.2"></polygon><polygon
+
          class="desc3-1" d="M96.7 62.9h-5.5L88.5 58l2.8-4.8h5.4l2.8 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="491.5 645.1 482.4 645.1 477.8 637.2 482.4 629.2 491.5 629.2 496.1 637.2 491.5 645.1"></polygon><polygon
+
          class="desc3-1" d="M96.7 53.4h-5.5l-2.7-4.8 2.8-4.8h5.4l2.8 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="491.5 629.2 482.4 629.2 477.8 621.3 482.4 613.4 491.5 613.4 496.1 621.3 491.5 629.2"></polygon><polygon
+
          class="desc3-1" d="M105 58.1h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.8L105 58z"></path><path
  
−
            class="NNTbe-1" points="505.3 637.2 496.1 637.2 491.6 629.2 496.1 621.3 505.3 621.3 509.8 629.2 505.3 637.2"></polygon><polygon
+
          class="desc3-1" d="M105 67.6h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM113.3 72.3h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="477.8 558 468.7 558 464.1 550.1 468.7 542.2 477.8 542.2 482.4 550.1 477.8 558"></polygon><polygon
+
          class="desc3-1" d="M113.3 62.9h-5.5L105 58l2.8-4.8h5.5l2.7 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="491.6 565.9 482.5 565.9 477.9 558 482.5 550.1 491.6 550.1 496.2 558 491.6 565.9"></polygon><polygon
+
          class="desc3-1" d="M121.5 67.6H116l-2.8-4.7L116 58h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="491.6 550.1 482.5 550.1 477.9 542.2 482.5 534.2 491.6 534.2 496.2 542.2 491.6 550.1"></polygon><polygon
+
          class="desc3-1" d="M121.5 58.1H116l-2.8-4.8 2.8-4.7h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="505.3 558 496.2 558 491.6 550.1 496.2 542.2 505.3 542.2 509.9 550.1 505.3 558"></polygon><polygon
+
          class="desc3-1" d="M129.7 62.9h-5.5l-2.7-4.8 2.7-4.8h5.5l2.8 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="505.3 542.2 496.2 542.2 491.6 534.2 496.2 526.3 505.3 526.3 509.9 534.2 505.3 542.2"></polygon><polygon
+
          class="desc3-7" d="M63.7 119.8h-5.5l-2.8 4.8 2.8 4.8h5.5l2.7-4.8-2.7-4.8zM72 115h-5.5l-2.8 4.8 2.8 4.8H72l2.7-4.8-2.8-4.7z"></path><path
  
−
            class="NNTbe-1" points="519.1 550.1 509.9 550.1 505.4 542.2 509.9 534.2 519.1 534.2 523.6 542.2 519.1 550.1"></polygon><polygon
+
          class="desc3-7" d="M72 124.6h-5.5l-2.8 4.7 2.8 4.8H72l2.7-4.8-2.8-4.7z"></path><path
  
−
            class="NNTbe-1" points="464.2 597.6 455.1 597.6 450.5 589.7 455.1 581.7 464.2 581.7 468.8 589.7 464.2 597.6"></polygon><polygon
+
          class="desc3-1" d="M80.2 119.8h-5.5l-2.8 4.8 2.8 4.7h5.5l2.7-4.7-2.7-4.8zM80.2 129.3h-5.5l-2.8 4.8 2.8 4.7h5.5l2.7-4.7-2.7-4.8zM88.4 124.6H83l-2.7 4.7 2.7 4.8h5.5l2.8-4.8-2.8-4.7z"></path><path
  
−
            class="NNTbe-1" points="478 605.5 468.9 605.5 464.3 597.6 468.9 589.7 478 589.7 482.6 597.6 478 605.5"></polygon><polygon
+
          class="desc3-7" d="M66.5 210.2H72l2.7-4.8-2.8-4.7h-5.4l-2.8 4.7 2.8 4.8zM58.2 215h5.5l2.7-4.8-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="478 589.7 468.9 589.7 464.3 581.7 468.9 573.8 478 573.8 482.6 581.7 478 589.7"></polygon><polygon
+
          class="desc3-7" d="M58.2 205.4h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="491.7 597.6 482.6 597.6 478 589.7 482.6 581.7 491.7 581.7 496.3 589.7 491.7 597.6"></polygon><polygon
+
          class="desc3-1" d="M50 210.2h5.5l2.7-4.8-2.8-4.7H50l-2.8 4.7 2.8 4.8zM50 200.7h5.5l2.7-4.8-2.8-4.7H50l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="491.7 581.7 482.6 581.7 478 573.8 482.6 565.9 491.7 565.9 496.3 573.8 491.7 581.7"></polygon><polygon
+
          class="desc3-1" d="M41.7 205.4h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7zM83 229h5.4l2.8-4.7-2.8-4.7H83l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="505.4 589.7 496.3 589.7 491.7 581.7 496.3 573.8 505.4 573.8 510 581.7 505.4 589.7"></polygon><polygon
+
          class="desc3-7" d="M74.7 233.8H80l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="427.6 597.5 436.7 597.5 441.3 589.6 436.7 581.7 427.6 581.7 423 589.6 427.6 597.5"></polygon><polygon
+
          class="desc3-1" d="M74.7 224.3H80l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="413.8 605.5 422.9 605.5 427.5 597.6 422.9 589.6 413.8 589.6 409.2 597.6 413.8 605.5"></polygon><polygon
+
          class="desc3-7" d="M66.4 229H72l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM66.4 219.6H72l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM58.2 224.3h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="413.8 589.6 422.9 589.6 427.5 581.7 422.9 573.8 413.8 573.8 409.2 581.7 413.8 589.6"></polygon><polygon
+
          class="desc3-1" d="M80.1 214.8h-5.4l-2.8-4.7 2.8-4.8H80l2.8 4.8-2.8 4.7zM88.4 219.6H83l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="400 597.6 409.2 597.6 413.8 589.6 409.2 581.7 400 581.7 395.5 589.6 400 597.6"></polygon><polygon
+
          class="desc3-1" d="M88.4 210H83l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="400 581.7 409.2 581.7 413.8 573.8 409.2 565.9 400 565.9 395.5 573.8 400 581.7"></polygon><polygon
+
          class="desc3-1" d="M96.6 214.8h-5.4l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM96.6 205.3h-5.4l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM104.9 210h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM88.4 162.6H83l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="386.3 589.6 395.5 589.6 400 581.7 395.5 573.8 386.3 573.8 381.8 581.7 386.3 589.6"></polygon><polygon
+
          class="desc3-1" d="M96.7 167.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7zM96.7 157.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="468.7 621.3 477.8 621.3 482.4 613.4 477.8 605.5 468.7 605.5 464.1 613.4 468.7 621.3"></polygon><polygon
+
          class="desc3-1" d="M105 162.6h-5.6l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="454.9 629.2 464 629.2 468.6 621.3 464 613.4 454.9 613.4 450.3 621.3 454.9 629.2"></polygon><polygon
+
          class="desc3-1" d="M105 153h-5.6l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="454.9 613.4 464 613.4 468.6 605.5 464 597.6 454.9 597.6 450.3 605.5 454.9 613.4"></polygon><polygon
+
          class="desc3-1" d="M113.2 157.8h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7zM80.2 186.3h-5.5l-2.7-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM88.5 191H83l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8zM88.5 181.6H83l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="441.2 621.3 450.3 621.3 454.9 613.4 450.3 605.5 441.2 605.5 436.6 613.4 441.2 621.3"></polygon><polygon
+
          class="desc3-1" d="M96.7 186.3h-5.5l-2.7-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM96.7 176.8h-5.5l-2.7-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="441.2 605.5 450.3 605.5 454.9 597.6 450.3 589.7 441.2 589.7 436.6 597.6 441.2 605.5"></polygon><polygon
+
          class="desc3-1" d="M105 181.6h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM83 200.6h5.4l2.8-4.8-2.8-4.7H83l-2.7 4.7 2.7 4.8zM74.7 205.3H80l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="427.5 613.4 436.6 613.4 441.2 605.5 436.6 597.6 427.5 597.6 422.9 605.5 427.5 613.4"></polygon><polygon
+
          class="desc3-1" d="M74.7 195.8H80l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="436.7 581.9 427.5 581.9 423 574 427.5 566.1 436.7 566.1 441.2 574 436.7 581.9"></polygon><polygon
+
          class="desc3-7" d="M66.4 200.6H72l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="450.5 589.9 441.3 589.9 436.8 582 441.3 574 450.5 574 455 582 450.5 589.9"></polygon><polygon
+
          class="desc3-7" d="M66.4 191H72l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM58.2 195.8h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7zM63.7 177h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="450.5 574 441.3 574 436.8 566.1 441.3 558.2 450.5 558.2 455 566.1 450.5 574"></polygon><polygon
+
          class="desc3-7" d="M72 181.7h-5.5l-2.7-4.7 2.7-4.8H72l2.7 4.8-2.7 4.7zM72 172.2h-5.5l-2.7-4.7 2.7-4.8H72l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="464.2 582 455 582 450.5 574 455 566.1 464.2 566.1 468.8 574 464.2 582"></polygon><polygon
+
          class="desc3-1" d="M80.2 177h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8zM80.2 167.5h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="464.2 566.1 455 566.1 450.5 558.2 455 550.3 464.2 550.3 468.8 558.2 464.2 566.1"></polygon><polygon
+
          class="desc3-1" d="M88.5 172.2H83l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM47.2 167.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM55.5 172H50l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8zM55.5 162.6H50l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="477.9 574 468.8 574 464.2 566.1 468.8 558.2 477.9 558.2 482.5 566.1 477.9 574"></polygon><polygon
+
          class="desc3-7" d="M63.7 167.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM63.7 157.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="409.2 565.9 400 565.9 395.5 558 400 550.1 409.2 550.1 413.7 558 409.2 565.9"></polygon><polygon
+
          class="desc3-7" d="M72 162.6h-5.5l-2.8-4.8 2.8-4.7H72l2.7 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="423 573.8 413.8 573.8 409.3 565.9 413.8 558 423 558 427.5 565.9 423 573.8"></polygon><polygon
+
          class="desc3-1" d="M47.2 148.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM55.5 153H50l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8zM55.5 143.6H50l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="423 558 413.8 558 409.3 550.1 413.8 542.1 423 542.1 427.5 550.1 423 558"></polygon><polygon
+
          class="desc3-7" d="M63.7 148.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM63.7 138.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="436.7 565.9 427.5 565.9 423 558 427.5 550.1 436.7 550.1 441.2 558 436.7 565.9"></polygon><polygon
+
          class="desc3-7" d="M72 143.6h-5.5l-2.8-4.8 2.8-4.7H72l2.7 4.7-2.8 4.8zM182 181.6h5.5l2.8 4.7-2.8 4.8H182l-2.7-4.8 2.7-4.7z"></path><path
  
−
            class="NNTbe-1" points="436.7 550.1 427.5 550.1 423 542.1 427.5 534.2 436.7 534.2 441.2 542.1 436.7 550.1"></polygon><polygon
+
          class="desc3-7" d="M173.8 176.8h5.4l2.8 4.8-2.8 4.7h-5.4l-2.8-4.7 2.8-4.8zM173.8 186.3h5.4l2.8 4.8-2.8 4.7h-5.4l-2.8-4.7 2.8-4.8z"></path><path
  
−
            class="NNTbe-1" points="450.4 558 441.3 558 436.7 550.1 441.3 542.1 450.4 542.1 455 550.1 450.4 558"></polygon><polygon
+
          class="desc3-7" d="M165.5 181.6h5.5l2.8 4.7-2.8 4.8h-5.5l-2.7-4.8 2.7-4.7z"></path><path
  
−
            class="NNTbe-1" points="409.2 534.2 400 534.2 395.5 526.3 400 518.4 409.2 518.4 413.7 526.3 409.2 534.2"></polygon><polygon
+
          class="desc3-7" d="M165.5 191h5.5l2.8 4.8-2.8 4.8h-5.5l-2.7-4.8 2.7-4.7z"></path><path
  
−
            class="NNTbe-1" points="423 542.2 413.8 542.2 409.3 534.2 413.8 526.3 423 526.3 427.5 534.2 423 542.2"></polygon><polygon
+
          class="desc3-1" d="M157.3 186.3h5.5l2.7 4.8-2.7 4.7h-5.5l-2.7-4.7 2.7-4.8zM154.3 219.6H149l-2.8-4.8 2.8-4.7h5.4l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="423 526.3 413.8 526.3 409.3 518.4 413.8 510.5 423 510.5 427.5 518.4 423 526.3"></polygon><polygon
+
          class="desc3-1" d="M162.6 224.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM162.6 214.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="436.7 534.2 427.5 534.2 423 526.3 427.5 518.4 436.7 518.4 441.2 526.3 436.7 534.2"></polygon><polygon
+
          class="desc3-7" d="M170.8 219.6h-5.4l-2.8-4.8 2.8-4.7h5.4l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="436.7 518.4 427.5 518.4 423 510.5 427.5 502.6 436.7 502.6 441.2 510.5 436.7 518.4"></polygon><polygon
+
          class="desc3-7" d="M170.8 210h-5.4l-2.8-4.7 2.8-4.7h5.4l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="450.4 526.3 441.3 526.3 436.7 518.4 441.3 510.5 450.4 510.5 455 518.4 450.4 526.3"></polygon><polygon
+
          class="desc3-7" d="M179 214.8h-5.4l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7zM187.5 248H182l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.8zM195.8 252.8h-5.5l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="450.4 542.2 441.3 542.2 436.7 534.2 441.3 526.3 450.4 526.3 455 534.2 450.4 542.2"></polygon><polygon
+
          class="desc3-7" d="M195.8 243.3h-5.5l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="464.2 550.1 455.1 550.1 450.5 542.2 455.1 534.2 464.2 534.2 468.8 542.2 464.2 550.1"></polygon><polygon
+
          class="desc3-7" d="M204 248h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM204 238.6h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="464.2 534.2 455.1 534.2 450.5 526.3 455.1 518.4 464.2 518.4 468.8 526.3 464.2 534.2"></polygon><polygon
+
          class="desc3-7" d="M212.2 243.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM182 238.7h5.5l2.7-4.8-2.7-4.7H182l-2.7 4.7 2.7 4.8zM173.7 243.4h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="477.9 542.2 468.8 542.2 464.2 534.2 468.8 526.3 477.9 526.3 482.5 534.2 477.9 542.2"></polygon><polygon
+
          class="desc3-7" d="M173.7 234h5.5l2.8-4.8-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="477.9 526.3 468.8 526.3 464.2 518.4 468.8 510.5 477.9 510.5 482.5 518.4 477.9 526.3"></polygon><polygon
+
          class="desc3-7" d="M165.5 238.7h5.5l2.7-4.8-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8zM165.5 229.2h5.5l2.7-4.8-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="491.6 534.2 482.5 534.2 477.9 526.3 482.5 518.4 491.6 518.4 496.2 526.3 491.6 534.2"></polygon><polygon
+
          class="desc3-7" d="M157.3 234h5.4l2.8-4.8-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7zM198.5 229h5.5l2.7-4.7-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8zM190.2 233.8h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="381.6 629.2 372.4 629.2 367.9 637.2 372.4 645.1 381.6 645.1 386.1 637.2 381.6 629.2"></polygon><polygon
+
          class="desc3-7" d="M190.2 224.3h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="395.4 621.3 386.2 621.3 381.7 629.2 386.2 637.2 395.4 637.2 399.9 629.2 395.4 621.3"></polygon><polygon
+
          class="desc3-7" d="M182 229h5.5l2.7-4.7-2.7-4.7H182l-2.7 4.7 2.7 4.8zM182 219.6h5.5l2.7-4.8-2.7-4.7H182l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="395.4 637.2 386.2 637.2 381.7 645.1 386.2 653 395.4 653 399.9 645.1 395.4 637.2"></polygon><polygon
+
          class="desc3-7" d="M173.8 224.3h5.4l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7zM198.5 210h5.5l2.7-4.7-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8zM190.2 214.8h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="409.1 629.2 399.9 629.2 395.4 637.2 399.9 645.1 409.1 645.1 413.7 637.2 409.1 629.2"></polygon><polygon
+
          class="desc3-7" d="M190.2 205.3h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="409.1 645.1 399.9 645.1 395.4 653 399.9 660.9 409.1 660.9 413.7 653 409.1 645.1"></polygon><polygon
+
          class="desc3-7" d="M182 210h5.5l2.7-4.7-2.7-4.7H182l-2.7 4.7 2.7 4.8zM182 200.6h5.5l2.7-4.8-2.7-4.7H182l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="422.8 637.2 413.7 637.2 409.1 645.1 413.7 653 422.8 653 427.4 645.1 422.8 637.2"></polygon><polygon
+
          class="desc3-7" d="M173.8 205.3h5.4l2.8-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7zM72 153h-5.5l-2.8-4.7 2.8-4.7H72l2.7 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="386.2 779.8 395.4 779.8 399.9 771.9 395.4 763.9 386.2 763.9 381.7 771.9 386.2 779.8"></polygon><polygon
+
          class="desc3-1" d="M80.2 157.8h-5.5l-2.7-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM80.2 148.3h-5.5l-2.7-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="372.4 787.7 381.6 787.7 386.1 779.8 381.6 771.9 372.4 771.9 367.9 779.8 372.4 787.7"></polygon><polygon
+
          class="desc3-1" d="M88.5 153H83l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM88.5 143.6H83l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="372.4 771.9 381.6 771.9 386.1 764 381.6 756 372.4 756 367.9 764 372.4 771.9"></polygon><polygon
+
          class="desc3-1" d="M96.7 148.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-8" points="358.7 779.8 367.9 779.8 372.4 771.9 367.9 764 358.7 764 354.2 771.9 358.7 779.8"></polygon><polygon
+
          class="desc3-7" d="M173.6 167.3h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-8" points="358.7 764 367.9 764 372.4 756 367.9 748.1 358.7 748.1 354.2 756 358.7 764"></polygon><polygon
+
          class="desc3-7" d="M165.3 172h5.5l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM165.3 162.6h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-8" points="345 771.9 354.1 771.9 358.7 764 354.1 756 345 756 340.4 764 345 771.9"></polygon><polygon
+
          class="desc3-1" d="M157.1 167.3h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7zM157.1 157.8h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="413.7 811.3 422.8 811.3 427.4 803.4 422.8 795.5 413.7 795.5 409.1 803.4 413.7 811.3"></polygon><polygon
+
          class="desc3-1" d="M148.9 162.6h5.5l2.7-4.8-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8zM121.3 143.6H116l-2.8 4.7 2.8 4.8h5.4l2.8-4.8-2.8-4.7z"></path><path
  
−
            class="NNTbe-1" points="399.9 819.2 409 819.2 413.6 811.3 409 803.4 399.9 803.4 395.3 811.3 399.9 819.2"></polygon><polygon
+
          class="desc3-1" d="M129.6 138.8h-5.4l-2.8 4.8 2.8 4.7h5.4l2.8-4.7-2.8-4.8zM129.6 148.3h-5.4l-2.8 4.8 2.8 4.7h5.4l2.8-4.7-2.8-4.8z"></path><path
  
−
            class="NNTbe-1" points="399.9 803.4 409 803.4 413.6 795.5 409 787.5 399.9 787.5 395.3 795.5 399.9 803.4"></polygon><polygon
+
          class="desc3-1" d="M137.9 143.6h-5.5l-2.8 4.7 2.8 4.8h5.5l2.7-4.8-2.7-4.7z"></path><path
  
−
            class="NNTbe-1" points="386.2 811.3 395.3 811.3 399.9 803.4 395.3 795.5 386.2 795.5 381.6 803.4 386.2 811.3"></polygon><polygon
+
          class="desc3-1" d="M137.9 153h-5.5l-2.8 4.8 2.8 4.8h5.5l2.7-4.8-2.7-4.7z"></path><path
  
−
            class="NNTbe-1" points="386.2 795.5 395.3 795.5 399.9 787.5 395.3 779.6 386.2 779.6 381.6 787.5 386.2 795.5"></polygon><polygon
+
          class="desc3-1" d="M146 148.3h-5.4l-2.7 4.8 2.7 4.7h5.5l2.7-4.7-2.7-4.8z"></path><path
  
−
            class="NNTbe-1" points="372.4 803.4 381.6 803.4 386.1 795.5 381.6 787.5 372.4 787.5 367.9 795.5 372.4 803.4"></polygon><polygon
+
          class="desc3-7" d="M124.2 234h5.4l2.8-4.8-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7zM115.9 238.7h5.4l2.8-4.8-2.8-4.7H116l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="409 787.5 399.9 787.5 395.3 779.6 399.9 771.7 409 771.7 413.6 779.6 409 787.5"></polygon><polygon
+
          class="desc3-1" d="M115.9 229.2h5.4l2.8-4.8-2.8-4.7H116l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="422.8 795.5 413.7 795.5 409.1 787.6 413.7 779.6 422.8 779.6 427.4 787.6 422.8 795.5"></polygon><polygon
+
          class="desc3-7" d="M107.6 234h5.5l2.8-4.8-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="422.8 779.6 413.7 779.6 409.1 771.7 413.7 763.8 422.8 763.8 427.4 771.7 422.8 779.6"></polygon><polygon
+
          class="desc3-1" d="M107.6 224.4h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="436.5 787.6 427.4 787.6 422.8 779.6 427.4 771.7 436.5 771.7 441.1 779.6 436.5 787.6"></polygon><polygon
+
          class="desc3-1" d="M99.4 229.2h5.5l2.7-4.8-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="436.5 771.7 427.4 771.7 422.8 763.8 427.4 755.9 436.5 755.9 441.1 763.8 436.5 771.7"></polygon><polygon
+
          class="desc3-7" d="M140.6 252.8h5.5l2.7-4.7-2.7-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="450.2 779.6 441.1 779.6 436.5 771.7 441.1 763.8 450.2 763.8 454.8 771.7 450.2 779.6"></polygon><polygon
+
          class="desc3-7" d="M132.3 257.6h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM132.3 248h5.5l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM124.1 252.8h5.5l2.7-4.7-2.7-4.8H124l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="422.8 700.5 413.7 700.5 409.1 692.6 413.7 684.6 422.8 684.6 427.4 692.6 422.8 700.5"></polygon><polygon
+
          class="desc3-7" d="M124.1 243.3h5.5l2.7-4.7-2.7-4.8H124l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="436.6 708.4 427.5 708.4 422.9 700.5 427.5 692.6 436.6 692.6 441.2 700.5 436.6 708.4"></polygon><polygon
+
          class="desc3-7" d="M115.9 248h5.4l2.8-4.7-2.8-4.7H116l-2.8 4.7 2.8 4.8zM137.8 238.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="436.6 692.6 427.5 692.6 422.9 684.6 427.5 676.7 436.6 676.7 441.2 684.6 436.6 692.6"></polygon><polygon
+
          class="desc3-7" d="M146 243.3h-5.4l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7zM146 233.8h-5.4l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7zM154.3 238.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="450.3 700.5 441.2 700.5 436.6 692.6 441.2 684.6 450.3 684.6 454.9 692.6 450.3 700.5"></polygon><polygon
+
          class="desc3-1" d="M154.3 229h-5.5l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="450.3 684.6 441.2 684.6 436.6 676.7 441.2 668.8 450.3 668.8 454.9 676.7 450.3 684.6"></polygon><polygon
+
          class="desc3-7" d="M162.6 233.8H157l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="464 692.6 454.9 692.6 450.3 684.6 454.9 676.7 464 676.7 468.6 684.6 464 692.6"></polygon><polygon
+
          class="desc3-1" d="M146 186.3h-5.4l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7zM154.4 191h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM154.4 181.6h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="409.2 740.1 400 740.1 395.5 732.1 400 724.2 409.2 724.2 413.7 732.1 409.2 740.1"></polygon><polygon
+
          class="desc3-1" d="M162.6 186.3H157l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7zM162.6 176.8H157l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="423 748 413.8 748 409.3 740.1 413.8 732.1 423 732.1 427.5 740.1 423 748"></polygon><polygon
+
          class="desc3-7" d="M170.8 181.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="423 732.1 413.8 732.1 409.3 724.2 413.8 716.3 423 716.3 427.5 724.2 423 732.1"></polygon><polygon
+
          class="desc3-1" d="M138 210h-5.6l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="436.7 740.1 427.5 740.1 423 732.1 427.5 724.2 436.7 724.2 441.2 732.1 436.7 740.1"></polygon><polygon
+
          class="desc3-1" d="M146.2 214.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7zM146.2 205.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7zM154.4 210H149l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8zM154.4 200.6H149l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="436.7 724.2 427.5 724.2 423 716.3 427.5 708.4 436.7 708.4 441.2 716.3 436.7 724.2"></polygon><polygon
+
          class="desc3-1" d="M162.7 205.3h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7zM116 210h5.4l2.8-4.7-2.8-4.7H116l-2.7 4.7 2.7 4.8zM107.6 214.8h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="450.4 732.1 441.3 732.1 436.7 724.2 441.3 716.3 450.4 716.3 455 724.2 450.4 732.1"></polygon><polygon
+
          class="desc3-1" d="M107.6 205.3h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="413.7 763.8 422.8 763.8 427.4 755.9 422.8 748 413.7 748 409.1 755.9 413.7 763.8"></polygon><polygon
+
          class="desc3-1" d="M99.4 210h5.5l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM99.4 200.6h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="399.9 771.7 409 771.7 413.6 763.8 409 755.9 399.9 755.9 395.3 763.8 399.9 771.7"></polygon><polygon
+
          class="desc3-1" d="M91.2 205.3h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7zM140.6 224.3h5.5l2.7-4.7-2.7-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="399.9 755.9 409 755.9 413.6 748 409 740.1 399.9 740.1 395.3 748 399.9 755.9"></polygon><polygon
+
          class="desc3-1" d="M132.3 229h5.5l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM132.3 219.6h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM124.1 224.3h5.5l2.7-4.7-2.7-4.8H124l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="386.2 763.8 395.3 763.8 399.9 755.9 395.3 748 386.2 748 381.6 755.9 386.2 763.8"></polygon><polygon
+
          class="desc3-1" d="M124.1 214.8h5.5l2.7-4.7-2.7-4.8H124l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="386.2 748 395.3 748 399.9 740.1 395.3 732.1 386.2 732.1 381.6 740.1 386.2 748"></polygon><polygon
+
          class="desc3-1" d="M115.9 219.6h5.4l2.8-4.8-2.8-4.7H116l-2.8 4.7 2.8 4.8zM121.4 200.7h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="372.4 755.9 381.6 755.9 386.1 748 381.6 740.1 372.4 740.1 367.9 748 372.4 755.9"></polygon><polygon
+
          class="desc3-1" d="M129.7 205.5h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM129.7 196h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM137.9 200.7h-5.5l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="381.6 724.4 372.5 724.4 367.9 716.5 372.5 708.6 381.6 708.6 386.2 716.5 381.6 724.4"></polygon><polygon
+
          class="desc3-1" d="M137.9 191.2h-5.5l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="395.4 732.4 386.3 732.4 381.7 724.4 386.3 716.5 395.4 716.5 400 724.4 395.4 732.4"></polygon><polygon
+
          class="desc3-1" d="M146.1 196h-5.4l-2.8-4.8 2.8-4.7h5.4l2.8 4.7-2.8 4.8zM104.9 191h-5.5l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8zM113.2 195.8h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="395.4 716.5 386.3 716.5 381.7 708.6 386.3 700.7 395.4 700.7 400 708.6 395.4 716.5"></polygon><polygon
+
          class="desc3-1" d="M113.2 186.3h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="409.2 724.4 400 724.4 395.4 716.5 400 708.6 409.2 708.6 413.7 716.5 409.2 724.4"></polygon><polygon
+
          class="desc3-1" d="M121.4 191h-5.5l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8zM121.4 181.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="409.2 708.6 400 708.6 395.4 700.7 400 692.8 409.2 692.8 413.7 700.7 409.2 708.6"></polygon><polygon
+
          class="desc3-1" d="M129.6 186.3h-5.4l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM129.6 138.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="422.9 716.5 413.7 716.5 409.2 708.6 413.7 700.7 422.9 700.7 427.4 708.6 422.9 716.5"></polygon><polygon
+
          class="desc3-1" d="M137.9 143.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-8" points="354.1 708.4 345 708.4 340.4 700.5 345 692.5 354.1 692.5 358.7 700.5 354.1 708.4"></polygon><polygon
+
          class="desc3-1" d="M137.9 134h-5.5l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-8" points="367.9 716.3 358.8 716.3 354.2 708.4 358.8 700.5 367.9 700.5 372.5 708.4 367.9 716.3"></polygon><polygon
+
          class="desc3-1" d="M146.1 138.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM146.1 129.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM154.3 134H149l-2.8-4.7 2.8-4.7h5.4l2.8 4.7-2.8 4.8zM129.7 110.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM138 115.1h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-8" points="367.9 700.5 358.8 700.5 354.2 692.6 358.8 684.6 367.9 684.6 372.5 692.6 367.9 700.5"></polygon><polygon
+
          class="desc3-1" d="M138 105.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="381.6 708.4 372.5 708.4 367.9 700.5 372.5 692.6 381.6 692.6 386.2 700.5 381.6 708.4"></polygon><polygon
+
          class="desc3-1" d="M146.2 110.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="381.6 692.6 372.5 692.6 367.9 684.6 372.5 676.7 381.6 676.7 386.2 684.6 381.6 692.6"></polygon><polygon
+
          class="desc3-1" d="M146.2 100.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="395.4 700.5 386.2 700.5 381.7 692.6 386.2 684.6 395.4 684.6 399.9 692.6 395.4 700.5"></polygon><polygon
+
          class="desc3-1" d="M154.4 105.6H149l-2.8-4.8 2.8-4.7h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-8" points="354.1 676.7 345 676.7 340.4 668.8 345 660.9 354.1 660.9 358.7 668.8 354.1 676.7"></polygon><polygon
+
          class="desc3-7" d="M173.6 158h5.5l2.8-4.8-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-8" points="367.9 684.6 358.8 684.6 354.2 676.7 358.8 668.8 367.9 668.8 372.5 676.7 367.9 684.6"></polygon><polygon
+
          class="desc3-7" d="M165.3 162.7h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM165.3 153.2h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-8" points="367.9 668.8 358.8 668.8 354.2 660.9 358.8 653 367.9 653 372.5 660.9 367.9 668.8"></polygon><polygon
+
          class="desc3-1" d="M157.1 158h5.5l2.8-4.8-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="381.6 676.7 372.5 676.7 367.9 668.8 372.5 660.9 381.6 660.9 386.2 668.8 381.6 676.7"></polygon><polygon
+
          class="desc3-1" d="M157.1 148.4h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="381.6 660.9 372.5 660.9 367.9 653 372.5 645.1 381.6 645.1 386.2 653 381.6 660.9"></polygon><polygon
+
          class="desc3-1" d="M148.9 153.2h5.5l2.7-4.8-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="395.4 668.8 386.2 668.8 381.7 660.9 386.2 653 395.4 653 399.9 660.9 395.4 668.8"></polygon><polygon
+
          class="desc3-7" d="M190 176.8h5.6l2.7-4.7-2.7-4.8H190l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="578.9 732.1 588 732.1 592.6 740 588 748 578.9 748 574.3 740 578.9 732.1"></polygon><polygon
+
          class="desc3-7" d="M181.8 181.6h5.5l2.7-4.8-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="565.1 724.2 574.2 724.2 578.8 732.1 574.2 740 565.1 740 560.5 732.1 565.1 724.2"></polygon><polygon
+
          class="desc3-7" d="M181.8 172h5.5l2.7-4.7-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8zM173.6 176.8h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="565.1 740 574.2 740 578.8 748 574.2 755.9 565.1 755.9 560.5 748 565.1 740"></polygon><polygon
+
          class="desc3-7" d="M173.6 167.3h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="551.3 732.1 560.5 732.1 565.1 740 560.5 748 551.3 748 546.8 740 551.3 732.1"></polygon><polygon
+
          class="desc3-7" d="M165.3 172h5.5l2.8-4.7-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM187.3 162.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="551.3 748 560.5 748 565.1 755.9 560.5 763.8 551.3 763.8 546.8 755.9 551.3 748"></polygon><polygon
+
          class="desc3-7" d="M195.6 167.3H190l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM195.6 157.8H190l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM203.8 162.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="537.6 740 546.8 740 551.3 748 546.8 755.9 537.6 755.9 533.1 748 537.6 740"></polygon><polygon
+
          class="desc3-7" d="M203.8 153h-5.5l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="532.7 795.5 523.6 795.5 519 787.5 523.6 779.6 532.7 779.6 537.3 787.5 532.7 795.5"></polygon><polygon
+
          class="desc3-7" d="M212 157.8h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM195.6 110.3H190l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM203.8 115h-5.4l-2.8-4.7 2.8-4.7h5.4l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="546.5 803.4 537.4 803.4 532.8 795.5 537.4 787.5 546.5 787.5 551.1 795.5 546.5 803.4"></polygon><polygon
+
          class="desc3-7" d="M203.8 105.6h-5.4l-2.8-4.8 2.8-4.7h5.4l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="546.5 787.5 537.4 787.5 532.8 779.6 537.4 771.7 546.5 771.7 551.1 779.6 546.5 787.5"></polygon><polygon
+
          class="desc3-7" d="M212 110.3h-5.4l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM212 100.8h-5.4l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM220.3 105.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8zM187.4 134h-5.5l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="560.2 795.5 551.1 795.5 546.5 787.5 551.1 779.6 560.2 779.6 564.8 787.5 560.2 795.5"></polygon><polygon
+
          class="desc3-7" d="M195.7 138.8h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM195.7 129.3h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM203.9 134h-5.5l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8zM203.9 124.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="560.2 779.6 551.1 779.6 546.5 771.7 551.1 763.8 560.2 763.8 564.8 771.7 560.2 779.6"></polygon><polygon
+
          class="desc3-7" d="M212.1 129.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7zM165.4 134h5.5l2.7-4.7-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="573.9 787.5 564.8 787.5 560.2 779.6 564.8 771.7 573.9 771.7 578.5 779.6 573.9 787.5"></polygon><polygon
+
          class="desc3-1" d="M157.1 138.8h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7zM157.1 129.3h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="587.9 842.9 578.8 842.9 574.2 835 578.8 827.1 587.9 827.1 592.5 835 587.9 842.9"></polygon><polygon
+
          class="desc3-1" d="M148.9 134h5.5l2.7-4.7-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8zM140.7 148.4h5.5l2.7-4.8-2.8-4.7h-5.4l-2.8 4.7 2.8 4.8zM148.9 124.6h5.5l2.7-4.8-2.7-4.7h-5.5l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="601.7 850.8 592.6 850.8 588 842.9 592.6 835 601.7 835 606.3 842.9 601.7 850.8"></polygon><polygon
+
          class="desc3-1" d="M140.7 129.3h5.5l2.7-4.7-2.8-4.8h-5.4l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="601.7 835 592.6 835 588 827.1 592.6 819.2 601.7 819.2 606.3 827.1 601.7 835"></polygon><polygon
+
          class="desc3-7" d="M190 148.3h5.6l2.7-4.7-2.7-4.8H190l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="615.4 842.9 606.3 842.9 601.7 835 606.3 827.1 615.4 827.1 620 835 615.4 842.9"></polygon><polygon
+
          class="desc3-7" d="M181.8 153h5.5l2.7-4.7-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8zM181.8 143.6h5.5l2.7-4.8-2.7-4.7h-5.5l-2.7 4.7 2.7 4.8zM173.6 148.3h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="615.4 827.1 606.3 827.1 601.7 819.2 606.3 811.3 615.4 811.3 620 819.2 615.4 827.1"></polygon><polygon
+
          class="desc3-7" d="M173.6 138.8h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="629.1 835 620 835 615.4 827.1 620 819.2 629.1 819.2 633.7 827.1 629.1 835"></polygon><polygon
+
          class="desc3-7" d="M165.3 143.6h5.5l2.8-4.8-2.8-4.7h-5.5l-2.7 4.7 2.7 4.8zM170.9 124.7h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="578.8 827.3 587.9 827.3 592.5 819.4 587.9 811.5 578.8 811.5 574.2 819.4 578.8 827.3"></polygon><polygon
+
          class="desc3-7" d="M179.2 129.5h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.8 4.8zM179.2 120h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="565 835.2 574.1 835.2 578.7 827.3 574.1 819.4 565 819.4 560.4 827.3 565 835.2"></polygon><polygon
+
          class="desc3-7" d="M187.4 124.7h-5.5L179 120l2.8-4.8h5.5l2.7 4.8-2.7 4.7zM187.4 115.2h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="565 819.4 574.1 819.4 578.7 811.5 574.1 803.6 565 803.6 560.4 811.5 565 819.4"></polygon><polygon
+
          class="desc3-7" d="M195.6 120h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="551.3 827.3 560.4 827.3 565 819.4 560.4 811.5 551.3 811.5 546.7 819.4 551.3 827.3"></polygon><polygon
+
          class="desc3-1" d="M154.3 77.1h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="551.3 811.5 560.4 811.5 565 803.6 560.4 795.7 551.3 795.7 546.7 803.6 551.3 811.5"></polygon><polygon
+
          class="desc3-1" d="M162.6 81.9H157l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.8 4.8zM162.6 72.4H157l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="537.5 819.4 546.7 819.4 551.3 811.5 546.7 803.6 537.5 803.6 533 811.5 537.5 819.4"></polygon><polygon
+
          class="desc3-7" d="M170.8 77.1h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7zM170.8 67.6h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="606.3 811.3 615.4 811.3 620 803.3 615.4 795.4 606.3 795.4 601.7 803.3 606.3 811.3"></polygon><polygon
+
          class="desc3-7" d="M179 72.4h-5.5l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="592.5 819.2 601.6 819.2 606.2 811.3 601.6 803.4 592.5 803.4 587.9 811.3 592.5 819.2"></polygon><polygon
+
          class="desc3-8" d="M162.6 24.9H157l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.8 4.8zM170.8 29.6h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="592.5 803.4 601.6 803.4 606.2 795.4 601.6 787.5 592.5 787.5 587.9 795.4 592.5 803.4"></polygon><polygon
+
          class="desc3-8" d="M170.8 20.1h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="578.8 811.3 587.9 811.3 592.5 803.4 587.9 795.4 578.8 795.4 574.2 803.4 578.8 811.3"></polygon><polygon
+
          class="desc3-8" d="M179 24.9h-5.4l-2.8-4.8 2.8-4.7h5.5l2.7 4.7L179 25z"></path><path
  
−
            class="NNTbe-1" points="578.8 795.4 587.9 795.4 592.5 787.5 587.9 779.6 578.8 779.6 574.2 787.5 578.8 795.4"></polygon><polygon
+
          class="desc3-8" d="M179 15.4h-5.4l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.8 4.8zM187.3 20.1h-5.5l-2.7-4.7 2.7-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="565.1 803.4 574.2 803.4 578.8 795.4 574.2 787.5 565.1 787.5 560.5 795.4 565.1 803.4"></polygon><polygon
+
          class="desc3-1" d="M154.4 48.6h-5.5L146 44 149 39h5.5L157 44l-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="606.3 779.6 615.4 779.6 620 771.7 615.4 763.8 606.3 763.8 601.7 771.7 606.3 779.6"></polygon><polygon
+
          class="desc3-1" d="M162.7 53.4h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.8 4.8zM162.7 43.9h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="592.5 787.5 601.6 787.5 606.2 779.6 601.6 771.7 592.5 771.7 587.9 779.6 592.5 787.5"></polygon><polygon
+
          class="desc3-7" d="M170.9 48.6h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="592.5 771.7 601.6 771.7 606.2 763.8 601.6 755.9 592.5 755.9 587.9 763.8 592.5 771.7"></polygon><polygon
+
          class="desc3-6" d="M170.9 39.1h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8L171 39z"></path><path
  
−
            class="NNTbe-1" points="578.8 779.6 587.9 779.6 592.5 771.7 587.9 763.8 578.8 763.8 574.2 771.7 578.8 779.6"></polygon><polygon
+
          class="desc3-7" d="M179.1 43.9h-5.5L171 39l2.7-4.7h5.5L182 39 179 44z"></path><path
  
−
            class="NNTbe-1" points="578.8 763.8 587.9 763.8 592.5 755.9 587.9 747.9 578.8 747.9 574.2 755.9 578.8 763.8"></polygon><polygon
+
          class="desc3-1" d="M157 62.9h5.6l2.7-4.8-2.8-4.7h-5.4l-2.8 4.7 2.8 4.8zM148.8 67.6h5.5L157 63l-2.7-4.8h-5.5L146 63l2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="565.1 771.7 574.2 771.7 578.8 763.8 574.2 755.9 565.1 755.9 560.5 763.8 565.1 771.7"></polygon><polygon
+
          class="desc3-1" d="M148.8 58.1h5.5l2.7-4.7-2.7-4.8h-5.5l-2.8 4.8 2.8 4.7zM140.6 62.9h5.5l2.7-4.8-2.8-4.7h-5.4l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="395.4 684.6 386.2 684.6 381.7 676.7 386.2 668.8 395.4 668.8 399.9 676.7 395.4 684.6"></polygon><polygon
+
          class="desc3-1" d="M140.6 53.4h5.5l2.7-4.8L146 44h-5.4l-2.8 4.7 2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="409.2 692.6 400 692.6 395.5 684.6 400 676.7 409.2 676.7 413.7 684.6 409.2 692.6"></polygon><polygon
+
          class="desc3-1" d="M132.3 58.1h5.5l2.8-4.7-2.8-4.8h-5.5l-2.7 4.8 2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="409.2 676.7 400 676.7 395.5 668.8 400 660.9 409.2 660.9 413.7 668.8 409.2 676.7"></polygon><polygon
+
          class="desc3-6" d="M137.9 39.2h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="422.9 684.6 413.7 684.6 409.2 676.7 413.7 668.8 422.9 668.8 427.4 676.7 422.9 684.6"></polygon><polygon
+
          class="desc3-1" d="M146.1 44h-5.4l-2.8-4.8 2.8-4.7h5.4l2.8 4.7L146 44z"></path><path
  
−
            class="NNTbe-1" points="422.9 668.8 413.7 668.8 409.2 660.9 413.7 653 422.9 653 427.4 660.9 422.9 668.8"></polygon><polygon
+
          class="desc3-8" d="M146.1 34.5h-5.4l-2.8-4.8 2.8-4.7h5.4l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="436.6 676.7 427.5 676.7 422.9 668.8 427.5 660.9 436.6 660.9 441.2 668.8 436.6 676.7"></polygon><polygon
+
          class="desc3-6" d="M154.4 39.2h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="564.8 708.4 574 708.4 578.5 700.5 574 692.5 564.8 692.5 560.3 700.5 564.8 708.4"></polygon><polygon
+
          class="desc3-8" d="M154.4 29.7h-5.5L146 25l2.8-4.8h5.5L157 25l-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="551 716.3 560.2 716.3 564.7 708.4 560.2 700.5 551 700.5 546.5 708.4 551 716.3"></polygon><polygon
+
          class="desc3-8" d="M162.6 34.5H157l-2.7-4.8L157 25h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="551 700.5 560.2 700.5 564.7 692.6 560.2 684.6 551 684.6 546.5 692.6 551 700.5"></polygon><polygon
+
          class="desc3-1" d="M154.4 115h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="537.3 708.4 546.5 708.4 551 700.5 546.5 692.6 537.3 692.6 532.7 700.5 537.3 708.4"></polygon><polygon
+
          class="desc3-1" d="M162.7 119.8h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7zM162.7 110.3h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="537.3 692.6 546.5 692.6 551 684.6 546.5 676.7 537.3 676.7 532.7 684.6 537.3 692.6"></polygon><polygon
+
          class="desc3-7" d="M170.9 115h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8zM170.9 105.6h-5.5l-2.8-4.8 2.8-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="523.6 700.5 532.7 700.5 537.3 692.6 532.7 684.6 523.6 684.6 519 692.6 523.6 700.5"></polygon><polygon
+
          class="desc3-7" d="M179.1 110.3h-5.5l-2.7-4.7 2.7-4.8h5.5l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="477.7 668.8 468.6 668.8 464 676.7 468.6 684.6 477.7 684.6 482.3 676.7 477.7 668.8"></polygon><polygon
+
          class="desc3-1" d="M104.9 172h-5.5l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8zM113.2 176.8h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="491.5 660.9 482.4 660.9 477.8 668.8 482.4 676.7 491.5 676.7 496.1 668.8 491.5 660.9"></polygon><polygon
+
          class="desc3-1" d="M113.2 167.3h-5.5l-2.8-4.7 2.8-4.8h5.5l2.7 4.8-2.7 4.7z"></path><path
  
−
            class="NNTbe-1" points="491.5 676.7 482.4 676.7 477.8 684.6 482.4 692.6 491.5 692.6 496.1 684.6 491.5 676.7"></polygon><polygon
+
          class="desc3-1" d="M121.4 172h-5.5l-2.7-4.7 2.7-4.7h5.5l2.7 4.7-2.7 4.8zM121.4 162.6h-5.5l-2.7-4.8 2.7-4.7h5.5l2.7 4.7-2.7 4.8z"></path><path
  
−
            class="NNTbe-1" points="505.2 668.8 496.1 668.8 491.5 676.7 496.1 684.6 505.2 684.6 509.8 676.7 505.2 668.8"></polygon><polygon
+
          class="desc3-1" d="M129.6 167.3h-5.4l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM129.6 176.8h-5.4l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="505.2 684.6 496.1 684.6 491.5 692.6 496.1 700.5 505.2 700.5 509.8 692.6 505.2 684.6"></polygon><polygon
+
          class="desc3-1" d="M138 181.6h-5.6l-2.7-4.8 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="518.9 676.7 509.8 676.7 505.2 684.6 509.8 692.6 518.9 692.6 523.5 684.6 518.9 676.7"></polygon><polygon
+
          class="desc3-1" d="M138 172h-5.6l-2.7-4.7 2.7-4.7h5.5l2.8 4.7-2.8 4.8z"></path><path
  
−
            class="NNTbe-1" points="482.4 819.3 491.5 819.3 496.1 811.4 491.5 803.5 482.4 803.5 477.8 811.4 482.4 819.3"></polygon><polygon
+
          class="desc3-1" d="M146.1 176.8h-5.4l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7zM146.1 167.3h-5.4l-2.8-4.7 2.8-4.8h5.4l2.8 4.8-2.8 4.7z"></path><path
  
−
            class="NNTbe-1" points="468.6 827.3 477.7 827.3 482.3 819.4 477.7 811.4 468.6 811.4 464 819.4 468.6 827.3"></polygon><polygon
+
          class="desc3-1" d="M154.4 172h-5.5l-2.8-4.7 2.8-4.7h5.5l2.7 4.7-2.7 4.8z"></path></g><rect
  
−
            class="NNTbe-1" points="468.6 811.4 477.7 811.4 482.3 803.5 477.7 795.6 468.6 795.6 464 803.5 468.6 811.4"></polygon><polygon
+
        class="desc3-1" x="103.5" y="56.2" width="49.8" height="168.1" rx="24.9"></rect><path
  
−
            class="NNTbe-1" points="454.9 819.4 464 819.4 468.6 811.4 464 803.5 454.9 803.5 450.3 811.4 454.9 819.4"></polygon><polygon
+
        class="desc3-9" d="M179.5 109.5h19.8l1.5-10.9c0-.4-3-1.5-3-3.8a3.9 3.9 0 014-4.1 3.8 3.8 0 013.7 3.9c0 1.7-3 4-3 4.2l-1.2 10.7c3.7-.2 8.5-1.2 11.8-6 1.2-1.5 1.8-3.3 3.8-4 1.5-.5 4-.4 5 1.2s1.4 4-1.5 5.3l-5.5.5a51 51 0 00-4.2 3l4 1.9 6.2.1c2 .3 4.5 2 4.3 4.4-.2 2.5-4 4.3-6 3.7-2.5-.6-4-4.7-4.7-5.7-.4-.5-8.4-3-8.3-2.6l.6 8c0 .4 2.3.8 2.6 1.8a2.3 2.3 0 01-1.6 3 2.4 2.4 0 01-3.4-1.3c-.5-1.5.6-2.7.6-3.3l-.5-8.1-19.6-.2M179.5 154h19.8l1.5-11c0-.4-3-1.5-3-3.7a3.9 3.9 0 117.7-.3c0 1.8-3 4-3 4.2l-1.2 10.7c3.7-.2 8.5-1.2 11.8-5.9 1.2-1.6 1.8-3.4 3.8-4 1.5-.6 4-.5 5 1.1s1.4 4-1.5 5.3l-5.5.5a51 51 0 00-4.2 3.1l4 1.8 6.2.2c2 .2 4.5 2 4.3 4.3-.2 2.5-4 4.3-6 3.8-2.5-.7-4-4.7-4.7-5.7-.4-.6-8.4-3-8.3-2.7l.6 8c0 .4 2.3.8 2.6 1.9a2.3 2.3 0 01-1.6 3 2.4 2.4 0 01-3.4-1.4c-.5-1.5.6-2.6.6-3.2l-.5-8.2-19.6-.2M179.5 198.4h19.8l1.5-11c0-.4-3-1.5-3-3.7a3.9 3.9 0 117.7-.3c0 1.8-3 4.1-3 4.3l-1.2 10.7c3.7-.3 8.5-1.2 11.8-6 1.2-1.6 1.8-3.3 3.8-4 1.5-.6 4-.5 5 1.2s1.4 3.9-1.5 5.3l-5.5.4a51 51 0 00-4.2 3.1l4 1.9 6.2.1c2 .3 4.5 2 4.3 4.3-.2 2.6-4 4.4-6 3.8-2.5-.7-4-4.7-4.7-5.7-.4-.5-8.4-3-8.3-2.6l.6 8c0 .4 2.3.7 2.6 1.8a2.3 2.3 0 01-1.6 3 2.4 2.4 0 01-3.4-1.3c-.5-1.5.6-2.7.6-3.3l-.5-8.2-19.6-.1"
  
−
            class="NNTbe-1" points="454.9 803.5 464 803.5 468.6 795.6 464 787.7 454.9 787.7 450.3 795.6 454.9 803.5"></polygon><polygon
+
        transform="translate(-26.3 -7.5)"></path><text transform="translate(238 144.4)"
  
−
            class="NNTbe-1" points="441.1 811.4 450.3 811.4 454.8 803.5 450.3 795.6 441.1 795.6 436.6 803.5 441.1 811.4"></polygon><polygon
+
        font-size="25.8" font-family="Lato-Italic,Lato" font-style="italic" fill="#fff">Aptamers
 +
        bound to a carbon nanotube</text></svg>
  
−
            class="NNTbe-1" points="509.8 850.9 518.9 850.9 523.5 842.9 518.9 835 509.8 835 505.2 842.9 509.8 850.9"></polygon><polygon
+
</div>
 +
<br>
  
−
            class="NNTbe-1" points="496 858.8 505.1 858.8 509.7 850.9 505.1 843 496 843 491.4 850.9 496 858.8"></polygon><polygon
+
<p id="device_Description_text" style="text-align: justify; font-size: 18px;">
 +
We will perform the SELEX (Systematic Evolution of Ligands By Exponential Enrichment) method to obtain these aptamers and with them build electrodes with high specificity.
 +
</p>
 +
<br>
  
−
            class="NNTbe-1" points="496 843 505.1 843 509.7 835 505.1 827.1 496 827.1 491.4 835 496 843"></polygon><polygon
+
<div id="nanotube_explanation">
 +
<img id="nanotube_explanation_png" src="https://2019.igem.org/wiki/images/2/2f/T--Pasteur_Paris--aptamers_explanation.png" style="width: 70%; margin-left: 15%;">
 +
</div>
 +
<p id="device_Description_text" style="text-align: center; font-size: 15px;">
 +
<i>Simplified operating principle for specific bacteria detection using a regular electrode and another one with our aptamers bound to carbon nanotubes.
 +
</i>
 +
<br>
 +
<br>
  
−
            class="NNTbe-1" points="482.3 850.9 491.4 850.9 496 843 491.4 835 482.3 835 477.7 843 482.3 850.9"></polygon><polygon
+
<p id="device_Description_text" style="text-align: justify; font-size: 18px;">
 +
Simplified operating principle for specific bacteria detection using a regular electrode and another one with our aptamers bound to carbon nanotubes.
 +
Our job will not settle for making a electrod-aptamers system capable of detecting and quantifying specific bacteria but it will also consist in the creation of an actual prototype capable of indicating which strain is responsible for the infection to a doctor, taking into account the user scenari, security, and the ethical responsibility linked to the device. We also aim at creating this device in such a way that it could be used in remote locations during humanitarian missions.
 +
</p>
 +
<br>
  
−
            class="NNTbe-1" points="482.3 835 491.4 835 496 827.1 491.4 819.2 482.3 819.2 477.7 827.1 482.3 835"></polygon><polygon
+
<p id="device_Description_refence_title" style="text-align: justify; font-size: 18px;">
−
 
+
<b>References:</b>
−
            class="NNTbe-1" points="468.6 843 477.7 843 482.3 835 477.7 827.1 468.6 827.1 464 835 468.6 843"></polygon><polygon
+
</p>
−
 
+
<p id="device_Description_refence_title" style="text-align: justify; font-size: 18px;">
−
            class="NNTbe-1" points="505.1 827.1 496 827.1 491.4 819.2 496 811.3 505.1 811.3 509.7 819.2 505.1 827.1"></polygon><polygon
+
Gustavo A. Zelada-Guillén and al., “Immediate Detection of Living Bacteria at Ultralow Concentrations Using a Carbon Nanotube Based Potentiometric Aptasensor”, Angew. Chem. Int. Ed., 2009, vol 48, pages 7334 –7337
−
 
+
<br><br>
−
            class="NNTbe-1" points="518.9 835 509.8 835 505.2 827.1 509.8 819.2 518.9 819.2 523.5 827.1 518.9 835"></polygon><polygon
+
Kwame Sefah, Dihua Shangguan, Xiangling Xiong, Meghan B O’Donoghue & Weihong Tan, “Development of DNA aptamers using Cell-SELEX”, Nature Protocols, 2010, vol 5, pages 1169–1185
−
 
+
</p>
−
            class="NNTbe-1" points="518.9 819.2 509.8 819.2 505.2 811.3 509.8 803.4 518.9 803.4 523.5 811.3 518.9 819.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.6 827.1 523.5 827.1 518.9 819.2 523.5 811.3 532.6 811.3 537.2 819.2 532.6 827.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.6 811.3 523.5 811.3 518.9 803.4 523.5 795.5 532.6 795.5 537.2 803.4 532.6 811.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.4 819.2 537.2 819.2 532.7 811.3 537.2 803.4 546.4 803.4 550.9 811.3 546.4 819.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="518.9 740 509.8 740 505.2 732.1 509.8 724.2 518.9 724.2 523.5 732.1 518.9 740"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.7 748 523.6 748 519 740.1 523.6 732.1 532.7 732.1 537.3 740.1 532.7 748"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.7 732.1 523.6 732.1 519 724.2 523.6 716.3 532.7 716.3 537.3 724.2 532.7 732.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.4 740.1 537.3 740.1 532.7 732.1 537.3 724.2 546.4 724.2 551 732.1 546.4 740.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.4 724.2 537.3 724.2 532.7 716.3 537.3 708.4 546.4 708.4 551 716.3 546.4 724.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="560.2 732.1 551 732.1 546.5 724.2 551 716.3 560.2 716.3 564.7 724.2 560.2 732.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.3 779.6 496.2 779.6 491.6 771.7 496.2 763.8 505.3 763.8 509.9 771.7 505.3 779.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519.1 787.6 510 787.6 505.4 779.6 510 771.7 519.1 771.7 523.7 779.6 519.1 787.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519.1 771.7 510 771.7 505.4 763.8 510 755.9 519.1 755.9 523.7 763.8 519.1 771.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.8 779.6 523.7 779.6 519.1 771.7 523.7 763.8 532.8 763.8 537.4 771.7 532.8 779.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.8 763.8 523.7 763.8 519.1 755.9 523.7 748 532.8 748 537.4 755.9 532.8 763.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.5 771.7 537.4 771.7 532.8 763.8 537.4 755.9 546.5 755.9 551.1 763.8 546.5 771.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="468.7 779.6 477.8 779.6 482.4 771.7 477.8 763.8 468.7 763.8 464.1 771.7 468.7 779.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="454.9 787.5 464 787.5 468.6 779.6 464 771.7 454.9 771.7 450.3 779.6 454.9 787.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="454.9 771.7 464 771.7 468.6 763.8 464 755.9 454.9 755.9 450.3 763.8 454.9 771.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="441.2 779.6 450.3 779.6 454.9 771.7 450.3 763.8 441.2 763.8 436.6 771.7 441.2 779.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="441.2 763.8 450.3 763.8 454.9 755.9 450.3 747.9 441.2 747.9 436.6 755.9 441.2 763.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="427.4 771.7 436.6 771.7 441.1 763.8 436.6 755.9 427.4 755.9 422.9 763.8 427.4 771.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="509.8 803.4 518.9 803.4 523.5 795.5 518.9 787.5 509.8 787.5 505.2 795.5 509.8 803.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="496 811.3 505.1 811.3 509.7 803.4 505.1 795.5 496 795.5 491.4 803.4 496 811.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="496 795.5 505.1 795.5 509.7 787.6 505.1 779.6 496 779.6 491.4 787.6 496 795.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="482.3 803.4 491.4 803.4 496 795.5 491.4 787.6 482.3 787.6 477.7 795.5 482.3 803.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="482.3 787.6 491.4 787.6 496 779.6 491.4 771.7 482.3 771.7 477.7 779.6 482.3 787.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="468.6 795.5 477.7 795.5 482.3 787.6 477.7 779.6 468.6 779.6 464 787.6 468.6 795.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="477.8 764 468.6 764 464.1 756.1 468.6 748.2 477.8 748.2 482.3 756.1 477.8 764"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="491.6 771.9 482.4 771.9 477.9 764 482.4 756.1 491.6 756.1 496.1 764 491.6 771.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="491.6 756.1 482.4 756.1 477.9 748.2 482.4 740.3 491.6 740.3 496.1 748.2 491.6 756.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.3 764 496.1 764 491.6 756.1 496.1 748.2 505.3 748.2 509.9 756.1 505.3 764"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.3 748.2 496.1 748.2 491.6 740.3 496.1 732.3 505.3 732.3 509.9 740.3 505.3 748.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519 756.1 509.9 756.1 505.3 748.2 509.9 740.3 519 740.3 523.6 748.2 519 756.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="450.3 747.9 441.1 747.9 436.6 740 441.1 732.1 450.3 732.1 454.8 740 450.3 747.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="464.1 755.9 454.9 755.9 450.4 748 454.9 740 464.1 740 468.6 748 464.1 755.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="464.1 740 454.9 740 450.4 732.1 454.9 724.2 464.1 724.2 468.6 732.1 464.1 740"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="477.8 748 468.6 748 464.1 740 468.6 732.1 477.8 732.1 482.3 740 477.8 748"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="477.8 732.1 468.6 732.1 464.1 724.2 468.6 716.3 477.8 716.3 482.3 724.2 477.8 732.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="491.5 740 482.4 740 477.8 732.1 482.4 724.2 491.5 724.2 496.1 732.1 491.5 740"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="491.5 660.9 482.3 660.9 477.8 653 482.3 645.1 491.5 645.1 496 653 491.5 660.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.3 668.8 496.1 668.8 491.6 660.9 496.1 653 505.3 653 509.8 660.9 505.3 668.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.3 653 496.1 653 491.6 645.1 496.1 637.1 505.3 637.1 509.8 645.1 505.3 653"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519 660.9 509.8 660.9 505.3 653 509.8 645.1 519 645.1 523.5 653 519 660.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519 645.1 509.8 645.1 505.3 637.1 509.8 629.2 519 629.2 523.5 637.1 519 645.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.7 653 523.6 653 519 645.1 523.6 637.1 532.7 637.1 537.3 645.1 532.7 653"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="491.6 613.4 482.5 613.4 477.9 605.5 482.5 597.6 491.6 597.6 496.2 605.5 491.6 613.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.4 621.3 496.3 621.3 491.7 613.4 496.3 605.5 505.4 605.5 510 613.4 505.4 621.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.4 605.5 496.3 605.5 491.7 597.6 496.3 589.7 505.4 589.7 510 597.6 505.4 605.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519.1 613.4 510 613.4 505.4 605.5 510 597.6 519.1 597.6 523.7 605.5 519.1 613.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519.1 597.6 510 597.6 505.4 589.7 510 581.7 519.1 581.7 523.7 589.7 519.1 597.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.9 605.5 523.7 605.5 519.1 597.6 523.7 589.7 532.9 589.7 537.4 597.6 532.9 605.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="564.8 692.7 574 692.7 578.5 684.8 574 676.9 564.8 676.9 560.3 684.8 564.8 692.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="551 700.6 560.2 700.6 564.7 692.7 560.2 684.8 551 684.8 546.5 692.7 551 700.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="551 684.8 560.2 684.8 564.7 676.9 560.2 669 551 669 546.5 676.9 551 684.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="537.3 692.7 546.5 692.7 551 684.8 546.5 676.9 537.3 676.9 532.7 684.8 537.3 692.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="537.3 676.9 546.5 676.9 551 669 546.5 661 537.3 661 532.7 669 537.3 676.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="523.6 684.8 532.7 684.8 537.3 676.9 532.7 669 523.6 669 519 676.9 523.6 684.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="592.3 724.2 601.4 724.2 606 716.3 601.4 708.4 592.3 708.4 587.7 716.3 592.3 724.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="578.5 732.1 587.6 732.1 592.2 724.2 587.6 716.3 578.5 716.3 573.9 724.2 578.5 732.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="578.5 716.3 587.6 716.3 592.2 708.4 587.6 700.5 578.5 700.5 573.9 708.4 578.5 716.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="564.7 724.2 573.9 724.2 578.5 716.3 573.9 708.4 564.7 708.4 560.2 716.3 564.7 724.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="564.7 708.4 573.9 708.4 578.5 700.5 573.9 692.5 564.7 692.5 560.2 700.5 564.7 708.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="551 716.3 560.2 716.3 564.7 708.4 560.2 700.5 551 700.5 546.5 708.4 551 716.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="587.6 700.5 578.5 700.5 573.9 692.5 578.5 684.6 587.6 684.6 592.2 692.5 587.6 700.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="601.4 708.4 592.3 708.4 587.7 700.5 592.3 692.6 601.4 692.6 606 700.5 601.4 708.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="601.4 692.6 592.3 692.6 587.7 684.6 592.3 676.7 601.4 676.7 606 684.6 601.4 692.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="615.1 700.5 606 700.5 601.4 692.6 606 684.6 615.1 684.6 619.7 692.6 615.1 700.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="615.1 684.6 606 684.6 601.4 676.7 606 668.8 615.1 668.8 619.7 676.7 615.1 684.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="628.8 692.6 619.7 692.6 615.1 684.6 619.7 676.7 628.8 676.7 633.4 684.6 628.8 692.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="601.4 613.4 592.3 613.4 587.7 605.5 592.3 597.6 601.4 597.6 606 605.5 601.4 613.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="615.2 621.3 606 621.3 601.5 613.4 606 605.5 615.2 605.5 619.8 613.4 615.2 621.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="615.2 605.5 606 605.5 601.5 597.6 606 589.7 615.2 589.7 619.8 597.6 615.2 605.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="628.9 613.4 619.8 613.4 615.2 605.5 619.8 597.6 628.9 597.6 633.5 605.5 628.9 613.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="628.9 597.6 619.8 597.6 615.2 589.7 619.8 581.7 628.9 581.7 633.5 589.7 628.9 597.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="642.6 605.5 633.5 605.5 628.9 597.6 633.5 589.7 642.6 589.7 647.2 597.6 642.6 605.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="587.8 653 578.6 653 574 645.1 578.6 637.1 587.8 637.1 592.3 645.1 587.8 653"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="601.6 660.9 592.4 660.9 587.8 653 592.4 645.1 601.6 645.1 606.1 653 601.6 660.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="601.6 645.1 592.4 645.1 587.8 637.1 592.4 629.2 601.6 629.2 606.1 637.1 601.6 645.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="615.3 653 606.1 653 601.6 645.1 606.1 637.1 615.3 637.1 619.8 645.1 615.3 653"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="615.3 637.1 606.1 637.1 601.6 629.2 606.1 621.3 615.3 621.3 619.8 629.2 615.3 637.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="629 645.1 619.8 645.1 615.3 637.1 619.8 629.2 629 629.2 633.6 637.1 629 645.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="551.1 653 560.3 653 564.8 645 560.3 637.1 551.1 637.1 546.5 645 551.1 653"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="537.3 660.9 546.5 660.9 551 653 546.5 645 537.3 645 532.7 653 537.3 660.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="537.3 645 546.5 645 551 637.1 546.5 629.2 537.3 629.2 532.7 637.1 537.3 645"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="523.6 653 532.8 653 537.3 645 532.8 637.1 523.6 637.1 519 645 523.6 653"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="509.9 676.8 519 676.8 523.6 668.9 519 661 509.9 661 505.3 668.9 509.9 676.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="523.6 637.1 532.8 637.1 537.3 629.2 532.8 621.3 523.6 621.3 519 629.2 523.6 637.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="509.9 645 519 645 523.6 637.1 519 629.2 509.9 629.2 505.3 637.1 509.9 645"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="592.3 676.7 601.4 676.7 606 668.8 601.4 660.9 592.3 660.9 587.7 668.8 592.3 676.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="578.5 684.6 587.6 684.6 592.2 676.7 587.6 668.8 578.5 668.8 573.9 676.7 578.5 684.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="578.5 668.8 587.6 668.8 592.2 660.9 587.6 653 578.5 653 573.9 660.9 578.5 668.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="564.7 676.7 573.9 676.7 578.5 668.8 573.9 660.9 564.7 660.9 560.2 668.8 564.7 676.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="564.7 660.9 573.9 660.9 578.5 653 573.9 645.1 564.7 645.1 560.2 653 564.7 660.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="551 668.8 560.2 668.8 564.7 660.9 560.2 653 551 653 546.5 660.9 551 668.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="560.2 637.3 551.1 637.3 546.5 629.4 551.1 621.5 560.2 621.5 564.8 629.4 560.2 637.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="574 645.3 564.9 645.3 560.3 637.4 564.9 629.4 574 629.4 578.6 637.4 574 645.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="574 629.4 564.9 629.4 560.3 621.5 564.9 613.6 574 613.6 578.6 621.5 574 629.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="587.7 637.4 578.6 637.4 574 629.4 578.6 621.5 587.7 621.5 592.3 629.4 587.7 637.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="587.7 621.5 578.6 621.5 574 613.6 578.6 605.7 587.7 605.7 592.3 613.6 587.7 621.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="601.5 629.4 592.3 629.4 587.8 621.5 592.3 613.6 601.5 613.6 606 621.5 601.5 629.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.6 558 523.4 558 518.9 550.1 523.4 542.2 532.6 542.2 537.1 550.1 532.6 558"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.4 565.9 537.2 565.9 532.7 558 537.2 550.1 546.4 550.1 550.9 558 546.4 565.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.4 550.1 537.2 550.1 532.7 542.2 537.2 534.3 546.4 534.3 550.9 542.2 546.4 550.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="560.1 558 550.9 558 546.4 550.1 550.9 542.2 560.1 542.2 564.6 550.1 560.1 558"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="560.1 542.2 550.9 542.2 546.4 534.3 550.9 526.3 560.1 526.3 564.6 534.3 560.1 542.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="573.8 550.1 564.7 550.1 560.1 542.2 564.7 534.3 573.8 534.3 578.4 542.2 573.8 550.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="546.4 470.9 537.2 470.9 532.7 463 537.2 455.1 546.4 455.1 550.9 463 546.4 470.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="560.2 478.9 551 478.9 546.5 470.9 551 463 560.2 463 564.7 470.9 560.2 478.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="560.2 463 551 463 546.5 455.1 551 447.2 560.2 447.2 564.7 455.1 560.2 463"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="573.9 470.9 564.7 470.9 560.2 463 564.7 455.1 573.9 455.1 578.4 463 573.9 470.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="573.9 455.1 564.7 455.1 560.2 447.2 564.7 439.3 573.9 439.3 578.4 447.2 573.9 455.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="587.6 463 578.5 463 573.9 455.1 578.5 447.2 587.6 447.2 592.2 455.1 587.6 463"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.7 510.5 523.6 510.5 519 502.6 523.6 494.7 532.7 494.7 537.3 502.6 532.7 510.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.5 518.4 537.4 518.4 532.8 510.5 537.4 502.6 546.5 502.6 551.1 510.5 546.5 518.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.5 502.6 537.4 502.6 532.8 494.7 537.4 486.8 546.5 486.8 551.1 494.7 546.5 502.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="560.2 510.5 551.1 510.5 546.5 502.6 551.1 494.7 560.2 494.7 564.8 502.6 560.2 510.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-7" points="560.2 494.7 551.1 494.7 546.5 486.8 551.1 478.9 560.2 478.9 564.8 486.8 560.2 494.7"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="574 502.6 564.8 502.6 560.3 494.7 564.8 486.8 574 486.8 578.5 494.7 574 502.6"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="537.2 534.3 546.4 534.3 550.9 526.3 546.4 518.4 537.2 518.4 532.7 526.3 537.2 534.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="523.4 542.2 532.6 542.2 537.1 534.3 532.6 526.3 523.4 526.3 518.9 534.3 523.4 542.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="523.4 526.3 532.6 526.3 537.1 518.4 532.6 510.5 523.4 510.5 518.9 518.4 523.4 526.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="509.7 534.3 518.9 534.3 523.4 526.3 518.9 518.4 509.7 518.4 505.2 526.3 509.7 534.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="509.7 518.4 518.9 518.4 523.4 510.5 518.9 502.6 509.7 502.6 505.2 510.5 509.7 518.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="496 526.3 505.1 526.3 509.7 518.4 505.1 510.5 496 510.5 491.4 518.4 496 526.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-7" points="505.2 494.9 496.1 494.9 491.5 487 496.1 479 505.2 479 509.8 487 505.2 494.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519 502.8 509.9 502.8 505.3 494.9 509.9 487 519 487 523.6 494.9 519 502.8"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="519 487 509.9 487 505.3 479.1 509.9 471.1 519 471.1 523.6 479.1 519 487"></polygon><polygon
+
−
 
+
−
            class="NNTbe-7" points="532.7 494.9 523.6 494.9 519 487 523.6 479.1 532.7 479.1 537.3 487 532.7 494.9"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="532.7 479.1 523.6 479.1 519 471.1 523.6 463.2 532.7 463.2 537.3 471.1 532.7 479.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-9" points="546.4 487 537.3 487 532.7 479.1 537.3 471.1 546.4 471.1 551 479.1 546.4 487"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.7 621.3 523.6 621.3 519 613.4 523.6 605.5 532.7 605.5 537.3 613.4 532.7 621.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.5 629.2 537.4 629.2 532.8 621.3 537.4 613.4 546.5 613.4 551.1 621.3 546.5 629.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="546.5 613.4 537.4 613.4 532.8 605.5 537.4 597.6 546.5 597.6 551.1 605.5 546.5 613.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="560.2 621.3 551.1 621.3 546.5 613.4 551.1 605.5 560.2 605.5 564.8 613.4 560.2 621.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="560.2 605.5 551.1 605.5 546.5 597.6 551.1 589.6 560.2 589.6 564.8 597.6 560.2 605.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="574 613.4 564.8 613.4 560.3 605.5 564.8 597.6 574 597.6 578.5 605.5 574 613.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="450.3 716.3 441.1 716.3 436.6 708.4 441.1 700.5 450.3 700.5 454.8 708.4 450.3 716.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="464.1 724.2 454.9 724.2 450.4 716.3 454.9 708.4 464.1 708.4 468.6 716.3 464.1 724.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="464.1 708.4 454.9 708.4 450.4 700.5 454.9 692.6 464.1 692.6 468.6 700.5 464.1 708.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="477.8 716.3 468.6 716.3 464.1 708.4 468.6 700.5 477.8 700.5 482.3 708.4 477.8 716.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="477.8 700.5 468.6 700.5 464.1 692.6 468.6 684.6 477.8 684.6 482.3 692.6 477.8 700.5"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="491.5 708.4 482.4 708.4 477.8 700.5 482.4 692.6 491.5 692.6 496.1 700.5 491.5 708.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="491.5 724.2 482.4 724.2 477.8 716.3 482.4 708.4 491.5 708.4 496.1 716.3 491.5 724.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.3 732.1 496.2 732.1 491.6 724.2 496.2 716.3 505.3 716.3 509.9 724.2 505.3 732.1"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="505.3 716.3 496.2 716.3 491.6 708.4 496.2 700.5 505.3 700.5 509.9 708.4 505.3 716.3"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519 724.2 509.9 724.2 505.3 716.3 509.9 708.4 519 708.4 523.6 716.3 519 724.2"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="519 708.4 509.9 708.4 505.3 700.5 509.9 692.6 519 692.6 523.6 700.5 519 708.4"></polygon><polygon
+
−
 
+
−
            class="NNTbe-1" points="532.7 716.3 523.6 716.3 519 708.4 523.6 700.5 532.7 700.5 537.3 708.4 532.7 716.3"></polygon></g><rect
+
−
 
+
−
          class="NNTbe-1" x="447.9" y="523.2" width="82.9" height="280.22" rx="41.5"
+
−
 
+
−
          ry="41.5"></rect><line class="NNTbe-4" x1="109.3" y1="471.2" x2="234.3"
+
−
 
+
−
          y2="471.2"></line><line class="NNTbe-4" x1="109.3" y1="528.4" x2="109.3"
+
−
 
+
−
          y2="473"></line><rect class="NNTbe-10" x="92.1" y="531.2" width="34.5" height="34.5"
+
−
 
+
−
          rx="12" ry="12"></rect><line class="NNTbe-11" x1="109.3" y1="774.9" x2="109.3"
+
−
 
+
−
          y2="571.2"></line><path class="NNTbe-12" d="M583,773.8h33.1c.1,0,2.4-17.5,2.4-18.1s-5-2.6-5-6.3,2.2-7,6.6-7a6.4,6.4,0,0,1,6.3,6.5c0,3-5,6.8-5,7.1s-2,17.8-2,17.8c6.2-.4,14.1-2,19.7-9.8,1.9-2.8,3-5.7,6.2-6.8s6.8-.8,8.4,2,2.3,6.5-2.4,8.8l-9.2.8a68.8,68.8,0,0,0-6.9,5.1s6.1,3,6.7,3.1l10.2.2c3.3.4,7.6,3.3,7.3,7.3s-6.8,7.2-10.2,6.2-6.6-7.8-7.7-9.5-14-4.9-13.9-4.4,1,12.7,1.1,13.4,3.8,1.3,4.2,3,0,4.1-2.6,5.1-4.8.3-5.7-2.2,1.1-4.4,1.1-5.5-.8-13.6-1-13.6l-32.5-.2"
+
−
 
+
−
          transform="translate(-52.2 -171.2)"></path><path class="NNTbe-12" d="M583,847.5h33.1c.1,0,2.4-17.5,2.4-18.1s-5-2.6-5-6.3,2.2-7,6.6-7a6.6,6.6,0,0,1,6.3,6.6c0,2.9-5,6.7-5,7s-2,17.8-2,17.8c6.2-.3,14.1-2,19.7-9.8,1.9-2.7,3-5.6,6.2-6.8s6.8-.8,8.4,2,2.3,6.5-2.4,8.9l-9.2.7a84.7,84.7,0,0,0-6.9,5.2s6.1,2.9,6.7,3l10.2.2c3.3.5,7.6,3.3,7.3,7.3s-6.8,7.2-10.2,6.3-6.6-7.9-7.7-9.6-14-4.9-13.9-4.3,1,12.6,1.1,13.3,3.8,1.3,4.2,3.1,0,4-2.6,5-4.8.3-5.7-2.2,1.1-4.4,1.1-5.4-.8-13.7-1-13.7l-32.5-.2"
+
−
 
+
−
          transform="translate(-52.2 -171.2)"></path><path class="NNTbe-12" d="M583,913.9h33.1c.1,0,2.4-17.5,2.4-18.1s-5-2.6-5-6.3,2.2-7,6.6-7a6.4,6.4,0,0,1,6.3,6.5c0,3-5,6.8-5,7.1s-2,17.8-2,17.8c6.2-.4,14.1-2,19.7-9.8,1.9-2.7,3-5.6,6.2-6.8s6.8-.8,8.4,2,2.3,6.5-2.4,8.8l-9.2.8a68.8,68.8,0,0,0-6.9,5.1s6.1,3,6.7,3.1l10.2.2c3.3.4,7.6,3.3,7.3,7.3s-6.8,7.2-10.2,6.2-6.6-7.8-7.7-9.5-14-4.9-13.9-4.4,1,12.7,1.1,13.4,3.8,1.3,4.2,3.1,0,4-2.6,5-4.8.3-5.7-2.2,1.1-4.4,1.1-5.4-.8-13.7-1-13.7l-32.5-.2"
+
−
 
+
−
          transform="translate(-52.2 -171.2)"></path><g class="NNTbe-13"><path class="NNTbe-14"
+
−
 
+
−
            d="M799.9,790.1a14.5,14.5,0,0,1-1.9,17.4c-2,1.9-4.5,3.4-5.7,5.8s-.6,6.3,1,9a18.4,18.4,0,0,0,12,8.9,18.7,18.7,0,0,0,14.7-2.8c5.9-4.1,8.9-11.2,10.5-18.2a66.1,66.1,0,0,0,.6-28.7c-1.3-7-3.9-14-8.7-19.2s-12.2-8.6-19.2-7.3a17.5,17.5,0,0,0-12.3,9.5,18.1,18.1,0,0,0,.2,15.6,37.2,37.2,0,0,0,6.5,8.3c1.5,1.6.9.2,2.3,1.7"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path><path class="NNTbe-14" d="M798.9,790.7a13.7,13.7,0,0,1-.3,14.1c-2,3.1-5.7,4.6-7.4,7.9-2.7,5.4,1.2,11.8,5.2,15.3,11.1,9.6,26.3,3.9,32.2-8.4,6.8-14.1,6.8-33.6.9-48-5-12.3-19.1-23.4-32.4-15.5a18.6,18.6,0,0,0-8.9,18.1c.8,7.4,5.8,12.2,10.9,16.8,1.1,1,2.8-.7,1.7-1.7-5.1-4.6-10.3-9.4-10.4-17a16.3,16.3,0,0,1,20-15.9c18.6,4.3,22,29.2,20.4,44.9-.8,8.5-2.9,18.3-9.3,24.3a17.5,17.5,0,0,1-24.9-.8c-4.3-4.6-5-10.1.1-14.6,2.2-2,4.1-3.8,5.2-6.6a15.9,15.9,0,0,0-.9-14.1c-.8-1.3-2.9-.1-2.1,1.2Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M803.4,737.1c-1.1,2.1-2.5,4.5-1.6,6.9a4.5,4.5,0,0,0,1.6,2.2c2.2,2,3.6,3.9,2.9,7-.1.8,1,1.1,1.2.4a8,8,0,0,0-.8-5.7,20.9,20.9,0,0,0-2-2.2c-2.7-2.7-1.8-5.3-.2-8,.4-.7-.7-1.3-1.1-.6Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M828.5,754.1a5.9,5.9,0,0,0-.1,5.2c1.1,3.3,2.2,6.1-.5,9.1-.5.6.4,1.4.9.8a7.3,7.3,0,0,0,2.1-5c.1-3.3-3-6.3-1.3-9.5.3-.7-.7-1.3-1.1-.6Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M832.5,785.5c3.4,4.2,8.9,2,13.2,1.2.8-.2.4-1.3-.3-1.2-3.9.8-9,2.9-12.1-.8-.4-.6-1.3.2-.8.8Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M832.1,805.3c1.9,1.5,3.9,2.9,5.8,4.5s2.3,3.6,2.1,6.1c-.1.8,1.1.8,1.2,0s.2-4.3-1.4-6.1-4.8-3.7-7.1-5.5c-.6-.5-1.2.6-.6,1Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M822.6,827c1.9,3.3,5,7,4.7,11-.1.8,1.1.8,1.2,0,.3-4.3-2.8-8.1-4.9-11.6a.6.6,0,1,0-1,.6Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M792.2,783.5a10.6,10.6,0,0,1-12.7,3.1c-.7-.3-1.1.9-.3,1.2a11.9,11.9,0,0,0,13.9-3.5c.5-.6-.4-1.4-.9-.8Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M785.1,755.9a13.6,13.6,0,0,0,3.1,10.6c.5.6,1.3-.2.9-.8a12.8,12.8,0,0,1-2.8-9.8c.1-.7-1.1-.7-1.2,0Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M782.4,814c-1.9-2.9,3.6-3.6,4.9-3.5a9.6,9.6,0,0,1,5.2,1.6.6.6,0,1,0,.6-1,10.4,10.4,0,0,0-9.2-1.3c-2.1.7-3.9,2.6-2.5,4.8a.6.6,0,1,0,1-.6Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><g class="NNTbe-13"><path
+
−
 
+
−
            class="NNTbe-14" d="M799.2,829.5a9.5,9.5,0,0,1-8.2,7,.6.6,0,0,0,0,1.2,10.8,10.8,0,0,0,9.4-7.9c.2-.7-1-1.1-1.2-.3Z"
+
−
 
+
−
            transform="translate(-52.2 -171.2)"></path></g><text class="NNTbe-15"
+
−
 
+
−
          transform="translate(358.2 125.6)">1</text><line class="NNTbe-3" x1="806.3"
+
−
 
+
−
          y1="188.6" x2="826.6" y2="188.6"></line><circle class="NNTbe-3" cx="726"
+
−
 
+
−
          cy="189.6" r="6.3"></circle><circle class="NNTbe-16" cx="800.8" cy="188.6"
+
  
−
          r="6.3"></circle></svg> </div>
 
 
</div>
 
</div>
  
 
      
 
      
 
</html>
 
</html>

Revision as of 22:01, 15 October 2019

  • Safety
  • Juddging Form
  • Human Pratices

  • Education
    Law
    Events
  • Project
  • Description
    Design
    Results
    Entrepreneurship
    Demonstrate
    Chalenges
    Improve
  • Team
  • Team members
    Collaborations
    Attributions
  • Sciences
  • Notebook
    Results Attributions
  • Awards
  • About Us

    • SAFETY

    JUDGING  FORM

    HUMAN  PRACTICES

  • Interview Collaboration Law & Ethics

    • PROJECT

  • Description Entrepreneurship Demonstrate Improve

    • HOME

    TEAM

  • Team members Attributions
    • Picto Sciences

    Sciences

  • Notebook Results
    • 1

    AWARDS

  • Medals Demonstrate Special Prizes
    • iGEMPASTEURPARIS2019

    ABOUT  US

    ecr-v-1
    ecr-p-2
    ecr-v-1
    ecr-p-2
    ecr-p-2
    ecr-p-2
    ecr-v-1
    ecr-p-2
    ecr-p-2
    ecr-v-1
    ecr-p-2
    ecr-v-1
    ecr-p-2
    ecr-p-2
    ecr-v-1
    ecr-p-2
    ecr-v-1
    ecr-p-2

    Project Inspiration and Description

    To this day, numerous medical TV shows are based on the difficulties of diagnosing diseases quickly. What if a device could allow a precise and instantaneous diagnosis of a disease?


    Viewing a more serious and realistic situation, today, someone dies of sepsis every 5 seconds in the world. Sepsis is a clinical syndrome of organ malfunction potentially fatal provoked by a deregulated host response to the infection. Its current diagnosis relies on hemoculture, Hemoculture is a slow process, while every hour spent to detect which strain is responsible for the infection greatly enhances the risks of neurological and muscular complications and drastically reduces the chances of survival.

    CIT LDC H2S URE BLOOD SAMPLES HEMOCULTURE API GALLERIES ANTIBIOGRAM 24H-48H CURRENT DIAGNOSTIC METHODS

    In this context, we decided to create DIANE (Diagnosis is Now Easier).


    Diane is a swift diagnosis device which aims at allowing the doctors to get almost immediate results of the body fluid sample analysis and to quickly provide the proper treatment to the patient.




    Time is a crucial element. The doctors often have to act even before getting the results of the analysis and launch a broad empirical antibiotic treatment based on hypothesis regarding the origin of the infection. This can lead to an inadequate and thus inefficient treatment, a loss of time and can eventually result in the diminution of the patient’s chances of survival. DIANE would be a major tool against sepsis, but not only. More broadly, it could be used for any situation suggesting a bacterial infection with the advantages of being almost instantaneous, specific and selective. A rapid diagnosis would allow to provide the proper antibiotic treatment immediately and therefore to enhance the chances of survival, to reduce the complications due to the infection, as well as contributing to the fight against antimicrobial resistance, which is one of the biggest current threats for the global public health.


    This device relies on an electrochemical detection of bacteria in a specific way using aptamers, single-strand RNA or DNA capable of binding to a specific ligand, connected to carbon nanotubes electrodes.


    Aptamers bound to a carbon nanotube

    We will perform the SELEX (Systematic Evolution of Ligands By Exponential Enrichment) method to obtain these aptamers and with them build electrodes with high specificity.


    Simplified operating principle for specific bacteria detection using a regular electrode and another one with our aptamers bound to carbon nanotubes.

    Simplified operating principle for specific bacteria detection using a regular electrode and another one with our aptamers bound to carbon nanotubes. Our job will not settle for making a electrod-aptamers system capable of detecting and quantifying specific bacteria but it will also consist in the creation of an actual prototype capable of indicating which strain is responsible for the infection to a doctor, taking into account the user scenari, security, and the ethical responsibility linked to the device. We also aim at creating this device in such a way that it could be used in remote locations during humanitarian missions.


    References:

    Gustavo A. Zelada-Guillén and al., “Immediate Detection of Living Bacteria at Ultralow Concentrations Using a Carbon Nanotube Based Potentiometric Aptasensor”, Angew. Chem. Int. Ed., 2009, vol 48, pages 7334 –7337

    Kwame Sefah, Dihua Shangguan, Xiangling Xiong, Meghan B O’Donoghue & Weihong Tan, “Development of DNA aptamers using Cell-SELEX”, Nature Protocols, 2010, vol 5, pages 1169–1185