Difference between revisions of "Team:MADRID UCM/Description"

Latest revision as of 16:37, 8 December 2019

DESCRIPTION – iGem Madrid

DESCRIPTION

Inspiration

Among the challenges that must be faced, the fight against deadly diseases seems a crucial point to address. Nowadays we have good levels of disease detection, but, although these technologies are solid and have huge potential, they still remain far from the scope of some areas of our planet. Unfortunately, these areas are often the most affected by epidemics and infectious diseases, preventable with an early detection system.

Our team directly addresses the challenge of applying a series of innovative technologies to the development of a practical, affordable and easy-to-use platform for the detection of water-related diseases in developing areas.

In addition to our main focus on creating an easy and accurate biological detection methodology, this kind of technology can help to optimize the sensing platforms in developing countries, saving money, time and the need of highly specialized human resources.

The Problem of Cholera

Cholera outbreaks are a major concern for public health in developing countries. Microbial contamination of the water used domestically makes dealing with the prevalence of this disease difficult. Early detection of the presence of cholera in household drinking water is crucial in the fight against the spread of the disease.

But the damage caused by cholera covers a wider area than just the health sphere: cholera outbreaks make populations dependent on foreign help and medicines. This dependence is a harsh strike to the autonomy and self-development of those populations. Just as cholera’s problems are not only physical but also socio-political, so must the solutions be.

More details

The Problem of current Sensing Methods

Currently, cholera is mainly sensed via detection of the pathogen’s genetic material: Polymerase Chain Reaction (PCR) and Loop Mediated Isothermal Amplification (LAMP) are the main DNA identification techniques. Although they are relatively simple and sensitive, they can only be performed by specialized individuals following multiple-step procedures.

This has driven the development of some Rapid Diagnosis Tests (RDTs), able to identify cholera in patients or environmental samples within reduced infrastructures. The vast majority of them are based on antibodies, using Lateral Flow Immunochromatography (LFA) assays. However, their rate of false positives can be up to 40%, and they only aim to detect cholera in patients already showing symptoms, instead of detecting the pathogen in environmental samples such as water or food.

More details

Why Aptamers?

We have bet on aptamers as the solution for the shortcomings that appear when analyzing current sensing methodologies. These resilient particles are short single-stranded deoxyribonucleic acid (DNA) molecules that can be designed to bind specifically to a target molecule.
Their nature, DNA or RNA, gives them a set of extremely useful characteristics

They are capable of resisting higher temperatures than other molecules, as well as extreme levels of pH or other harsh conditions

They are among the most cost-effective molecules to produce at this point in time

They are among the easiest molecules to manage in a wet lab

Maybe the most interesting feature they present is their tertiary structure, which allows highly specific binding to a target, as accurately as if they were two jigsaw pieces.

Aptamers are turning upside-down several biotechnology areas, gradually replacing the current golden-standard antibodies for four main reasons:

Captura de pantalla 2019-10-20 a las 1.29.25

Aptamers are, nowadays, the most cost-effective molecules to produce, as are all DNA molecules.

Aptamers are more stable than antibodies, and therefore can endure less favourable conditions.

Aptamers are more versatile than other molecules, as they can be engineered to bind along an extended target range which includes proteins, cell surfaces, etc. It is also possible to alter them or introduce modifications, so the improvement of their affinity, which facilitates the inclusion of the aptamer in the sensing method, is relatively uncomplicated.

Aptamer production does not involve experimenting with animals. Their development protocols are exclusively in vitro

Dive into our project

Disease

Disease selection & marker expression

The starting point of the development cycle of the new sensor. This step entailed the selection of the target disease (cholera), the study of its pathogenic agent, the choice of its protein marker and, finally, the expression of this marker in another lab bacteria (E.coli), completely safe thanks to our negative gram membrane display system.

After this, this synthetic biological platform (named Escherichia cholira in our proof of concept) went on to the next step: the RoboSELEX.

Keep going to learn more about the building of this platform!

SynBio

RoboSELEX

The second step of the process and central part of our technology. In this stage, we developed the molecules that support the detection of the specific pathogenic agents: aptamers.

Our goal for this year has been the automation of the whole aptamer-selection process (or SELEX) in order to both increase its reproducibility and facilitate the scaling of the pathogenic agents that it is able to detect.

In our vision “Robots making aptamers” we imagine a room full of pipetting robots working full-time constantly discovering new aptamers, so we can scale up our detection system and sense more and more diseases.

Dive into this part of the project under the RoboSELEX section in “Our Technology”!

RoboSELEX

Characterization

Immediately after the end of the SELEX process, a series of aptamers was generated. We knew that they were specific to our protein, but how could we discover to what extent?

To dig into the qualities of the aptamers and obtain necessary variables such as the affinity constant, we developed several automatic characterization protocols.

Discover how we did this under the “Aptamer Characterization” section.

Aptamer Characterization

folding

3D Folding & Computational improvement

Understanding the three-dimensional structure of aptamers is key for understanding the mechanisms that underlie their working principle.

Determining structural characteristics as the region where an aptamer and its ligand match can help us to direct further improvements in the most accurate way. This simplifies the SELEX process, as it stops being random, and improves efficacy.

In the course of this year, we took a number of folding algorithms from previous teams and rewrote the folding process. We did this by applying cutting-edge AI techniques for algorithm development, which created a faster and more efficient folding.

Do you want to know more about this process? Have a look at the “Aptamer Folding” section!

3D Folding & Computational improvement

HP

Sensor design & implementation

An aptamer is only a molecule. To develop the best hardware that can embrace the aptamer and raise it to its maximum potential, we have carried out a series of activities aimed at better understanding the needs of the population at hand and including them in the development of the sensor.

In this way, the development of the sensor has been intimately linked with our Human Practices, making this entanglement one of the main features of our project. We have based our work on the tangible effect it has on real human lives, by ensuring an interdisciplinary approach that accounts for all aspects of the subject at hand.

To this end, we made our fieldwork in Yaoundé, Cameroon a central part of the project; there, we worked together with local scientists and health workers to tackle the problem of cholera directly, rather than just withdrawing to the lab.

We believe it is essential to not limit science to Western hegemonic knowledge, which recreates colonial patterns of thought, and this community-based fieldwork has allowed us to situate our work amidst - not against - local forms of knowledge. As such, those affected by cholera are just as much part of the project as we are, and will in the future be able to use our protocols in an independent, self-sufficient way.

AptaSensors

The sensors

An aptamer is only a molecule. To develop the best hardware that can embrace the aptamer and raise it to its maximum potential, we have carried out a series of activities aimed at better understanding the needs of the population at hand and including them in the development of the sensor.

In this way, the development of the sensor has been intimately linked with our Human Practices, making this entanglement one of the main features of our project. We have based our work on the tangible effect it has on real human lives, by ensuring an interdisciplinary approach that accounts for all aspects of the subject at hand.

To this end, we made our fieldwork in Yaoundé, Cameroon a central part of the project; there, we worked together with local scientists and health workers to tackle the problem of cholera directly, rather than just withdrawing to the lab.

We believe it is essential to not limit science to Western hegemonic knowledge, which recreates colonial patterns of thought, and this community-based fieldwork has allowed us to situate our work amidst - not against - local forms of knowledge. As such, those affected by cholera are just as much part of the project as we are, and will in the future be able to use our protocols in an independent, self-sufficient way.

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.menu__container{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.desktop-menu .header-07 .menu--primary .menu__container > li > a{padding-top:57px;padding-bottom:57px;padding-left:18px;padding-right:18px;}.header-07.headroom--not-top .page-header-inner{background:#fff;background-color:#fff;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-08 .page-header-inner{border-bottom-width:0px;border-color:rgba(255, 255, 255, 0.3);background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-08.headroom--top .header-wrap{padding-top:25px;padding-bottom:25px;padding-left:0px;padding-right:0px;}.header-08 .wpml-ls-item-toggle, .header-08 .page-open-mobile-menu, .header-08 .page-open-main-menu, .header-08 .popup-search-wrap i, .header-08 .mini-cart .mini-cart-icon{color:#fff;}.header-08 .page-open-main-menu:hover, .header-08 .page-open-mobile-menu:hover i, .header-08 .popup-search-wrap:hover i, .header-08 .mini-cart .mini-cart-icon:hover{color:#fff;}.header-08 .wpml-ls-slot-shortcode_actions:hover > .js-wpml-ls-item-toggle{color:#fff!important;}.header-08 .mini-cart .mini-cart-icon:after{background-color:#fff;color:#222;}.desktop-menu .header-08 .menu__container{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.desktop-menu .header-08 .menu--primary .menu__container > li > a{padding-top:57px;padding-bottom:57px;padding-left:18px;padding-right:18px;}.header-08.headroom--not-top .page-header-inner{background:#000;background-color:#000;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-09 .page-header-inner{border-bottom-width:0px;border-color:rgba(255, 255, 255, 0.3);background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-09 .wpml-ls-item-toggle, .header-09 .header-social-networks a, .header-09 .page-open-mobile-menu i, .header-09 .popup-search-wrap i, .header-09 .mini-cart .mini-cart-icon{color:#fff;}.header-09 .header-social-networks a:hover, .header-09 .page-open-mobile-menu:hover i, .header-09 .popup-search-wrap:hover i, .header-09 .mini-cart .mini-cart-icon:hover{color:rgba(255, 255, 255, 0.5);}.header-09 .wpml-ls-slot-shortcode_actions:hover > .js-wpml-ls-item-toggle{color:rgba(255, 255, 255, 0.5)!important;}.header-09 .mini-cart .mini-cart-icon:after{background-color:#fff;color:#222;}.desktop-menu .header-09 .menu__container{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.desktop-menu .header-09 .menu--primary .menu__container > li > a{padding-top:57px;padding-bottom:57px;padding-left:18px;padding-right:18px;}.desktop-menu .header-09 .menu--primary .menu__container > li{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.header-09 .menu--primary a{line-height:1.18;font-size:16px;color:#fff;}.header-09 .menu--primary li:hover > a, .header-09 .menu--primary > ul > li > a:hover, .header-09 .menu--primary > ul > li > a:focus, .header-09 .menu--primary .current-menu-ancestor > a, .header-09 .menu--primary .current-menu-item > a{color:#fff;}.header-09.headroom--not-top .page-header-inner{background:rgba(0, 0, 0, 0.9);background-color:rgba(0, 0, 0, 0.9);background-repeat:no-repeat;background-position:center 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a:hover, .header-10 .popup-search-wrap:hover i, .header-10 .mini-cart .mini-cart-icon:hover, .header-10 .page-open-main-menu:hover, .header-10 .page-open-mobile-menu:hover i{color:#111;}.header-10 .mini-cart .mini-cart-icon:after{background-color:#111;color:#fff;}.desktop-menu .header-10 .header-center{margin-top:80px;margin-bottom:0px;margin-left:-60px;margin-right:-60px;}.desktop-menu .header-10 .menu--primary .menu__container > li > a{padding-top:21px;padding-bottom:21px;padding-left:60px;padding-right:60px;}.desktop-menu .header-10 .menu--primary .menu__container > li{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.header-10 .menu--primary a{font-weight:600;line-height:1.18;font-size:16px;color:#222222;}.header-10 .menu--primary li:hover > a, .header-10 .menu--primary > ul > li > a:hover, .header-10 .menu--primary > ul > li > a:focus, .header-10 .menu--primary .current-menu-ancestor > a, .header-10 .menu--primary .current-menu-item > a{color:#222222;}.header-10.headroom--not-top .page-header-inner{background:#ffffff;background-color:#ffffff;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-11 .page-header-inner{border-bottom-width:0px;border-color:rgba(255, 255, 255, 0.3);background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-11 .wpml-ls-item-toggle, .header-11 .header-social-networks a, .header-11 .page-open-mobile-menu i, .header-11 .popup-search-wrap i, .header-11 .mini-cart .mini-cart-icon{color:#222;}.header-11 .header-social-networks a:hover, .header-11 .page-open-mobile-menu:hover i, .header-11 .popup-search-wrap:hover i, .header-11 .mini-cart .mini-cart-icon:hover{color:#222;}.header-11 .wpml-ls-slot-shortcode_actions:hover > .js-wpml-ls-item-toggle{color:#222!important;}.header-11 .mini-cart .mini-cart-icon:after{background-color:#222222;color:#fff;}.desktop-menu .header-11 .menu__container{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.desktop-menu .header-11 .menu--primary .menu__container > li > a{padding-top:57px;padding-bottom:57px;padding-left:18px;padding-right:18px;}.desktop-menu .header-11 .menu--primary .menu__container > li{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.header-11 .menu--primary a{line-height:1.18;font-size:16px;color:#222;}.header-11 .menu--primary li:hover > a, .header-11 .menu--primary > ul > li > a:hover, .header-11 .menu--primary > ul > li > a:focus, .header-11 .menu--primary .current-menu-ancestor > a, .header-11 .menu--primary .current-menu-item > a{color:#222;}.header-11.headroom--not-top .page-header-inner{background:#ffffff;background-color:#ffffff;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-12 .page-header-inner{border-bottom-width:0px;border-color:#222;background:#fff;background-color:#fff;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;padding-top:24px;padding-bottom:24px;padding-left:0px;padding-right:0px;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-12 .wpml-ls-item-toggle, .header-12 .page-open-mobile-menu, .header-12 .page-open-main-menu, .header-12 .popup-search-wrap i, .header-12 .mini-cart .mini-cart-icon{color:#222;}.header-12 .page-open-main-menu:hover, .header-12 .page-open-mobile-menu:hover i, .header-12 .popup-search-wrap:hover i, .header-12 .mini-cart .mini-cart-icon:hover{color:#0038E3;}.header-12 .wpml-ls-slot-shortcode_actions:hover > .js-wpml-ls-item-toggle{color:#0038E3!important;}.header-12 .mini-cart .mini-cart-icon:after{background-color:#222;color:#fff;}.desktop-menu .header-12 .menu__container{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.desktop-menu .header-12 .menu--primary .menu__container > li > a{padding-top:57px;padding-bottom:57px;padding-left:18px;padding-right:18px;}.header-12.headroom--not-top .page-header-inner{background:#fff;background-color:#fff;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-13 .page-header-inner{border-bottom-width:0px;border-color:#222;}.header-13 .page-header-inner .header-left-wrap{background:#222;background-color:#222;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-13 .page-header-inner .header-right-wrap{background:#19d2a8;background-color:#19d2a8;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-13 .page-open-mobile-menu, .header-13 .page-open-main-menu, .header-13 .popup-search-wrap i, .header-13 .mini-cart .mini-cart-icon{color:#fff;}.header-13 .page-open-main-menu:hover, .header-13 .page-open-mobile-menu:hover i, .header-13 .popup-search-wrap:hover i, .header-13 .mini-cart .mini-cart-icon:hover{color:#fff;}.header-13 .mini-cart .mini-cart-icon:after{background-color:#fff;color:#222;}.header-13.headroom--not-top .page-header-inner{background:#fff;background-color:#fff;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-14 .page-header-inner{border-bottom-width:0px;border-color:rgba(255, 255, 255, 0.3);background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-14 .wpml-ls-item-toggle, .header-14 .page-open-mobile-menu, .header-14 .header-social-networks a, .header-14 .popup-search-wrap i, .header-14 .mini-cart .mini-cart-icon{color:#fff;}.header-14 .header-social-networks a:hover, .header-14 .page-open-mobile-menu:hover i, .header-14 .popup-search-wrap:hover i, .header-14 .mini-cart .mini-cart-icon:hover{color:#fff;}.header-14 .wpml-ls-slot-shortcode_actions:hover > .js-wpml-ls-item-toggle{color:#fff!important;}.header-14 .mini-cart .mini-cart-icon:after{background-color:#fff;color:#222;}.desktop-menu .header-14 .menu__container{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.desktop-menu .header-14 .menu--primary .menu__container > li > a{padding-top:51px;padding-bottom:51px;padding-left:18px;padding-right:18px;}.header-14 .menu--primary a{font-weight:500;line-height:1.18;font-size:16px;color:#fff;}.header-14 .menu--primary li:hover > a, .header-14 .menu--primary > ul > li > a:hover, .header-14 .menu--primary > ul > li > a:focus, .header-14 .menu--primary .current-menu-ancestor > a, .header-14 .menu--primary .current-menu-item > a{color:#fff;}.header-14.headroom--not-top .page-header-inner{background:#001029;background-color:#001029;background-repeat:no-repeat;background-position:center 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.wpml-ls-slot-shortcode_actions:hover > .js-wpml-ls-item-toggle{color:#fff!important;}.header-15 .mini-cart .mini-cart-icon:after{background-color:#fff;color:#222;}.header-15.headroom--not-top .page-header-inner{background:#000;background-color:#000;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-16 .page-header-inner{border-bottom-width:0px;border-color:rgba(255, 255, 255, 0.3);background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-16 .wpml-ls-item-toggle, .header-16 .page-open-mobile-menu i, .header-16 .popup-search-wrap i, .header-16 .mini-cart .mini-cart-icon{color:#fff;}.header-16 .page-open-mobile-menu:hover i, .header-16 .popup-search-wrap:hover i, .header-16 .mini-cart .mini-cart-icon:hover{color:#fff;}.header-16 .wpml-ls-slot-shortcode_actions:hover > .js-wpml-ls-item-toggle{color:#fff!important;}.header-16 .mini-cart .mini-cart-icon:after{background-color:#fff;color:#222;}.desktop-menu .header-16 .menu__container{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.desktop-menu .header-16 .menu--primary .menu__container > li > a{padding-top:41px;padding-bottom:41px;padding-left:15px;padding-right:15px;}.desktop-menu .header-16 .menu--primary .menu__container > li{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.header-16 .menu--primary a{font-weight:600;line-height:1.18;font-size:16px;color:#fff;}.header-16 .menu--primary li:hover > a, .header-16 .menu--primary > ul > li > a:hover, .header-16 .menu--primary > ul > li > a:focus, .header-16 .menu--primary .current-menu-ancestor > a, .header-16 .menu--primary .current-menu-item > a{color:#fff;}.header-16 .tm-button{color:#222;border-color:#fff;background-color:#fff;}.header-16 .tm-button:hover{color:#222;border-color:#fff;background-color:#fff;}.header-16.headroom--not-top .page-header-inner{background:rgba(0, 0, 0, 0.9);background-color:rgba(0, 0, 0, 0.9);background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-17.headroom--top .header-wrap{padding-top:32px;padding-bottom:32px;padding-left:0px;padding-right:0px;}.header-17 .page-header-inner{border-bottom-width:0px;border-color:#222;background-repeat:no-repeat;background-position:center center;background-attachment:scroll;-webkit-background-size:cover;-moz-background-size:cover;-ms-background-size:cover;-o-background-size:cover;background-size:cover;}.header-17 .wpml-ls-item-toggle, .header-17 .header-social-networks a, .header-17 .page-open-mobile-menu, .header-17 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a:hover{background-color:#222;border-color:#222;}.header-18 .mini-cart .mini-cart-icon:after{background-color:#222;color:#fff;}.desktop-menu .header-18 .menu__container{margin-top:0px;margin-bottom:0px;margin-left:-15px;margin-right:0px;}.desktop-menu .header-18 .menu--primary .menu__container > li > a{padding-top:58px;padding-bottom:58px;padding-left:15px;padding-right:15px;}.desktop-menu .header-18 .menu--primary .menu__container > li{margin-top:0px;margin-bottom:0px;margin-left:0px;margin-right:0px;}.header-18 .menu--primary a{font-weight:700;line-height:1.18;font-size:18px;color:#222222;}.header-18 .menu--primary li:hover > a, .header-18 .menu--primary > ul > li > a:hover, .header-18 .menu--primary > ul > li > a:focus, .header-18 .menu--primary .current-menu-ancestor > a, .header-18 .menu--primary .current-menu-item > a{color:#0038E3;}.header-18.headroom--not-top .page-header-inner{background:#fff;background-color:#fff;background-repeat:no-repeat;background-position:center 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+  </style>
+  <noscript>
+   <style>
+     .wpb_animate_when_almost_visible { opacity: 1; }
+   </style>
+  </noscript>
+ </head>
+ <body class="page-template-default page page-id-6224 desktop desktop-menu page-has-animation scroll-nav-style-01 header-sticky-both wide page-has-no-sidebar wpb-js-composer js-comp-ver-6.0.5 vc_responsive" data-content-width="1200" data-font="Open Sans Helvetica, Arial, sans-serif" data-header-sticky-height="80" data-site-width="1200px">
+<div class="header-sticky-both wpb-js-composer">
+  <div class="page-loading clearfix" id="page-preloader">
+   <div class="page-load-inner">
+    <div class="preloader-wrap">
+     <div class="wrap-2">
+      <div class="">
+       <img alt="Brook Preloader" src="/wiki/images/8/8b/T--MADRID_UCM--wp-content~uploads~2019~10~BUENO.gif"/>
+      </div>
+     </div>
+    </div>
+   </div>
+  </div>
+  <div class="site" id="page">
+   <div class="content-wrapper">
+    <header class="page-header header-09 header-layout-fixed light-logo-version" id="page-header">
+     <div class="page-header-place-holder">
+     </div>
+     <div class="page-header-inner" data-sticky="1" id="page-header-inner">
+      <div class="container">
+       <div class="row">
+        <div class="col-xs-12">
+         <div class="header-wrap">
+          <div class="branding">
+           <div class="branding__logo">
+            <a href="index.html" rel="home">
+             <img alt="iGem Madrid" class="light-logo" src="/wiki/images/e/e1/T--MADRID_UCM--wp-content~uploads~2019~10~aegis_logo_color-y-blanco_reduc-18.png"/>
+             <img alt="iGem Madrid" class="dark-logo" src="/wiki/images/1/1f/T--MADRID_UCM--wp-content~uploads~2019~09~aegis_logo_color_reduc.png"/>
+            </a>
+           </div>
+          </div>
+          <div class="header-right">
+           <div class="navigation page-navigation" id="page-navigation">
+            <nav class="menu menu--primary" id="menu">
+             <ul class="menu__container sm sm-simple" id="menu-our-menu">
+              <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3567 level-1" id="menu-item-3567">
+               <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM">
+                <div class="menu-item-wrap">
+                 <span class="menu-item-title">
+                  Home
+                 </span>
                  </div>
-                <div class="container">
+               </a>
-                    <div class="row">
+              </li>
-                        <div class="col-md-8 col-lg-6">
+              <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3571 level-1" id="menu-item-3571">
-                            <h1>AEGIS</h1>
+               <a data-ps2id-api="true">
-                            <p class="lead">
+                <div class="menu-item-wrap">
-                                An innovative collective of like-minded folks making useful and enduring technology products
+                 <span class="menu-item-title">
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+                  Our Project
-                        </div>
+                 </span>
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+                 <span class="toggle-sub-menu">
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+               </a>
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+               <ul class="sub-menu">
-            <section class="text-center">
+                 <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5034" id="menu-item-5034">
-                 <div class="container">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Description">
-                     <div class="row justify-content-center">
+                  <div class="menu-item-wrap">
-                        <div class="col-md-10 col-lg-8">
+                   <span class="menu-item-title">
-                            <h2>Built on passion and ingenuity</h2>
+                    Description
-                            <p class="lead">
+                   </span>
-                                Medium Rare is an elite author known for offering high-quality, high-value products backed by timely and personable support. Recognised and awarded by Envato on multiple occasions for producing consistently outstanding products, it's no wonder over 20,000 customers enjoy using Medium Rare templates.
+                  </div>
-                            </p>
+                 </a>
-                        </div>
+                 </li>
-                     </div>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5006" id="menu-item-5006">
-                     <!--end of row-->
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Design">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                     Our Design
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5007" id="menu-item-5007">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Collaborations">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Collaborations
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5008" id="menu-item-5008">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Attributions">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Attributions
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5009" id="menu-item-5009">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Team">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                     Team
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5010" id="menu-item-5010">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Sponsors">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                     Sponsors
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5011" id="menu-item-5011">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Gallery">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Gallery
+                   </span>
+                  </div>
+                 </a>
+                </li>
+               </ul>
+              </li>
+              <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3573 level-1" id="menu-item-3573">
+               <a data-ps2id-api="true">
+                <div class="menu-item-wrap">
+                 <span class="menu-item-title">
+                  Technology
+                 </span>
+                 <span class="toggle-sub-menu">
+                 </span>
                  </div>
-                 <!--end of container-->
+               </a>
-            </section>
+               <ul class="sub-menu">
-            <section class="text-center">
+                 <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5013" id="menu-item-5013">
-                <div class="container">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/roboselex.html">
-                     <div class="row">
+                  <div class="menu-item-wrap">
-                        <div class="col-md-11">
+                   <span class="menu-item-title">
-                            <div class="slider border--round" data-arrows="true" data-paging="true">
+                     Robo-SELEX
-                                <ul class="slides">
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-                                    <li>
+                  </div>
-                                        <img alt="Image" src="img/gallery-1.jpg" />
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-                                    </li>
+                </li>
-                                    <li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5014" id="menu-item-5014">
-                                        <img alt="Image" src="img/cowork-1.jpg" />
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Aptamer_Characterization">
-                                    </li>
+                  <div class="menu-item-wrap">
-                                    <li>
+                   <span class="menu-item-title">
-                                        <img alt="Image" src="img/cowork-5.jpg" />
+                    Aptamer characterization
-                                    </li>
+                   </span>
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-                    <!--end of row-->
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Aptasensors">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Aptasensors
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5016" id="menu-item-5016">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/aptamer-folding.html">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Aptamer folding
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5017" id="menu-item-5017">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Synbio">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    SynBio
+                   </span>
+                  </div>
+                 </a>
+                </li>
+               </ul>
+              </li>
+              <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3575 level-1" id="menu-item-3575">
+               <a data-ps2id-api="true">
+                <div class="menu-item-wrap">
+                 <span class="menu-item-title">
+                  Social Impact
+                 </span>
+                 <span class="toggle-sub-menu">
+                 </span>
                  </div>
-                 <!--end of container-->
+               </a>
-             </section>
+               <ul class="sub-menu">
-             <section class="text-center bg--secondary">
+                 <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5020" id="menu-item-5020">
-                 <div class="container">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Human_Practices">
-                     <div class="row justify-content-center">
+                  <div class="menu-item-wrap">
-                        <div class="col-md-10 col-lg-8">
+                   <span class="menu-item-title">
-                            <h2>What drives us</h2>
+                    Human Practices
-                            <p class="lead">
+                   </span>
-                                Whether you’re building a welcome mat for your SaaS or a clean, corporate portfolio, Stack has your design needs covered.
+                  </div>
-                            </p>
+                 </a>
-                        </div>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5021" id="menu-item-5021">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Public_Engagement">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Educational &amp; Engagement
+                   </span>
+                  </div>
+                 </a>
+                </li>
+               </ul>
+              </li>
+              <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-5018 level-1" id="menu-item-5018">
+               <a data-ps2id-api="true">
+                <div class="menu-item-wrap">
+                 <span class="menu-item-title">
+                  iGem Pages
+                 </span>
+                 <span class="toggle-sub-menu">
+                 </span>
+                </div>
+               </a>
+               <ul class="sub-menu">
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5024" id="menu-item-5024">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Model">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Modeling
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5025" id="menu-item-5025">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Improving">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Improving
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5026" id="menu-item-5026">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Entrepreneurship">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Entrepreneurship
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5027" id="menu-item-5027">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Software">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Software
+                   </span>
+                  </div>
+                 </a>
+                </li>
+                <li class="menu-item menu-item-type-custom menu-item-object-custom menu-item-5028" id="menu-item-5028">
+                 <a data-ps2id-api="true" href="http://2019.igem.org/Team:MADRID_UCM/Hardware">
+                  <div class="menu-item-wrap">
+                   <span class="menu-item-title">
+                    Hardware
+                   </span>
+                  </div>
+                 </a>
+                </li>
+               </ul>
+              </li>
+             </ul>
+            </nav>
+           </div>
+           <div class="header-social-networks">
+            <div class="inner">
+             <a aria-label="Instagram" class="social-link hint--bounce hint--bottom" data-hover="Instagram" href="https://instagram.com/madrid.igem?igshid=1gh862jd8ucbn" target="_blank">
+              <i class="social-icon fab fa-instagram">
+              </i>
+             </a>
+             <a aria-label="Twitter" class="social-link hint--bounce hint--bottom" data-hover="Twitter" href="https://twitter.com/igem_olm?s=09" target="_blank">
+              <i class="social-icon fab fa-twitter">
+              </i>
+             </a>
+            </div>
+           </div>
+           <div class="page-open-mobile-menu" id="page-open-mobile-menu">
+            <div class="inner">
+             <div class="icon">
+              <i>
+              </i>
+             </div>
+            </div>
+           </div>
+          </div>
+         </div>
+        </div>
+       </div>
+      </div>
+     </div>
+    </header>
+    <div class="page-content" id="page-content">
+     <div class="container">
+      <div class="row">
+       <div class="page-main-content" id="page-main-content">
+        <article class="post-6224 page type-page status-publish hentry post-no-thumbnail" id="post-6224">
+         <div class="vc_row vc_row-outer vc_row-fluid vc_container-has-overlay" data-vc-full-width="true" data-vc-full-width-init="false" data-vc-stretch-content="true" id="tm-row-5dae539748d0b">
+          <div class="vc_container-overlay">
+          </div>
+          <div class="wavify-wrapper">
+           <svg class="wavify-item" data-wavify-amplitude="50" data-wavify-background="#15d3ff" data-wavify-bones="6" data-wavify-height="0" height="100%" version="1.1" width="100%" xmlns="http://www.w3.org/2000/svg">
+            <title>
+             Wave
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+             <defs>
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+            <path d="">
+            </path>
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+           <svg class="wavify-item" data-wavify-amplitude="50" data-wavify-background="#ffffff" data-wavify-bones="5" data-wavify-height="0" height="100%" version="1.1" width="100%" xmlns="http://www.w3.org/2000/svg">
+            <title>
+             Wave
+            </title>
+            <defs>
+            </defs>
+            <path d="">
+            </path>
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+          <div class="wpb_column vc_column_container vc_col-sm-12" id="tm-column-5dae5397499c2">
+           <div class="vc_column-inner">
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+             <div class="tm-heading center tm-animation move-left" id="tm-heading-5dae539749c8d">
+              <h3 class="heading" style="">
+               DESCRIPTION
+              </h3>
+             </div>
+             <div class="tm-spacer" id="tm-spacer-5dae539749f47">
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+         <div class="vc_row-full-width vc_clearfix">
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+                 <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae53974b41a">
+                  <h3 class="heading" style="">
+                   Inspiration
+                  </h3>
+                 </div>
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+                  <div class="heading" style="">
+                   Among the challenges that must be faced, the fight against deadly diseases seems a crucial point to address. Nowadays we have good levels of disease detection, but, although these technologies are solid and have huge potential, they still remain far from the scope of some areas of our planet. Unfortunately, these areas are often the most affected by epidemics and infectious diseases, preventable with an early detection system.
+                  </div>
+                 </div>
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+                  <h4 class="heading" style="">
+                   <mark>
+                     Our team directly addresses the challenge of applying a series of innovative technologies to the development of a practical, affordable and easy-to-use platform for the detection of water-related diseases in developing areas.
+                   </mark>
+                  </h4>
+                 </div>
+                 <div class="tm-spacer" id="tm-spacer-5dae53974c725">
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+                  <div class="heading" style="">
+                   In addition to our main focus on creating an easy and accurate biological detection methodology, this kind of technology can help to optimize the sensing platforms in developing countries, saving money, time and the need of highly specialized human resources.
+                  </div>
+                 </div>
+                </div>
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+         </div>
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+                  <h3 class="heading" style="">
+                   The Problem of Cholera
+                  </h3>
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+                   Cholera outbreaks are a major concern for public health in developing countries. Microbial contamination of the water used domestically makes dealing with the prevalence of this disease difficult. Early detection of the presence of cholera in household drinking water is crucial in the fight against the spread of the disease.
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+                   But the damage caused by cholera covers a wider area than just the health sphere: cholera outbreaks make populations dependent on foreign help and medicines. This dependence is a harsh strike to the autonomy and self-development of those populations. Just as cholera’s problems are not only physical but also socio-political, so must the solutions be.
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+               <img alt="placa+azul" src="/wiki/images/6/6e/T--MADRID_UCM--wp-content~uploads~2019~10~placaazul.png"/>
+              </div>
+             </div>
+            </div>
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+              <h3 class="heading" style="">
+               The Problem of current Sensing Methods
+              </h3>
+             </div>
+             <div class="tm-spacer" id="tm-spacer-5dae53974fc19">
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+               Currently, cholera is mainly sensed via detection of the pathogen’s genetic material: Polymerase Chain Reaction (PCR) and Loop Mediated Isothermal Amplification (LAMP) are the main DNA identification techniques. Although they are relatively simple and sensitive, they can only be performed by specialized individuals following multiple-step procedures.
+              </div>
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+               This has driven the development of some Rapid Diagnosis Tests (RDTs), able to identify cholera in patients or environmental samples within reduced infrastructures. The vast majority of them are based on antibodies, using Lateral Flow Immunochromatography (LFA) assays. However, their rate of false positives can be up to 40%, and they only aim to detect cholera in patients already showing symptoms, instead of detecting the pathogen in environmental samples such as water or food.
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+               <span class="button-text" data-text="More details">
+                More details
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+                <i class="fa fa-arrow-right">
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+             <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae539750955">
+              <h3 class="heading" style="">
+               Why Aptamers?
+              </h3>
+             </div>
+             <div class="tm-spacer" id="tm-spacer-5dae539750ca9">
+             </div>
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+               We have bet on aptamers as the solution for the shortcomings that appear when analyzing current sensing methodologies. These resilient particles are short single-stranded deoxyribonucleic acid (DNA) molecules that can be designed to bind specifically to a target molecule.
+               <br/>
+               Their nature, DNA or RNA, gives them a set of extremely useful characteristics
+              </div>
+             </div>
+             <div class="tm-spacer" id="tm-spacer-5dae53975105d">
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+                </div>
+                <div class="title-wrap">
+                 <h6 class="title">
+                  They are capable of resisting higher temperatures than other molecules, as well as extreme levels of pH or other harsh conditions
+                 </h6>
+                </div>
+               </div>
+              </div>
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+               <div class="list-header">
+                <div class="marker">
+                </div>
+                <div class="title-wrap">
+                 <h6 class="title">
+                  They are among the most cost-effective molecules to produce at this point in time
+                 </h6>
+                </div>
+               </div>
+              </div>
+              <div class="list-item">
+               <div class="list-header">
+                <div class="marker">
+                </div>
+                <div class="title-wrap">
+                 <h6 class="title">
+                  They are among the easiest molecules to manage in a wet lab
+                 </h6>
+                </div>
+               </div>
+              </div>
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+               Maybe the most interesting feature they present is their tertiary structure, which allows highly specific binding to a target, as accurately as if they were two jigsaw pieces.
+              </div>
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+               Aptamers are turning upside-down several biotechnology areas, gradually replacing the current golden-standard antibodies for four main reasons:
+              </div>
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+              <div class="image">
+               <img alt="Captura de pantalla 2019-10-20 a las 1.29.25" src="/wiki/images/6/60/T--MADRID_UCM--wp-content~uploads~2019~10~Captura-de-pantalla-2019-10-20-a-las-1.29.25.png"/>
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+                 <h6 class="title">
+                  Aptamers are, nowadays, the most cost-effective molecules to produce, as are all DNA molecules.
+                 </h6>
+                </div>
+               </div>
+              </div>
+              <div class="list-item">
+               <div class="list-header">
+                <div class="marker">
+                 <i class="tm-list__icon fa fa-grip-lines">
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+                 <h6 class="title">
+                  Aptamers are more stable than antibodies, and therefore can endure less favourable conditions.
+                 </h6>
+                </div>
+               </div>
+              </div>
+              <div class="list-item">
+               <div class="list-header">
+                <div class="marker">
+                 <i class="tm-list__icon fa fa-grip-lines">
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+                 <h6 class="title">
+                  Aptamers are more versatile than other molecules, as they can be engineered to bind along an extended target range which includes proteins, cell surfaces, etc. It is also possible to alter them or introduce modifications, so the improvement of their affinity, which facilitates the inclusion of the aptamer in the sensing method, is relatively uncomplicated.
+                 </h6>
+                </div>
+               </div>
+              </div>
+              <div class="list-item">
+               <div class="list-header">
+                <div class="marker">
+                 <i class="tm-list__icon fa fa-grip-lines">
+                 </i>
+                </div>
+                <div class="title-wrap">
+                 <h6 class="title">
+                  Aptamer production does not involve experimenting with animals. Their development protocols are exclusively in vitro
+                 </h6>
+                </div>
+               </div>
+              </div>
+             </div>
+            </div>
+           </div>
+          </div>
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+              <h3 class="heading" style="">
+               Dive into our project
+              </h3>
+             </div>
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+              <div class="wpb_column vc_column_container vc_col-sm-6" id="tm-column-inner-5dae539753704">
-                <div class="container">
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+                 <div class="tm-tta-container" id="tm-tta-container-5dae539758ac9">
-                            <div class="feature">
+                  <div class="vc_tta-container" data-vc-action="collapse">
-                                <h4>Inclusion</h4>
+                   <div class="vc_general vc_tta vc_tta-tabs vc_tta-color-primary vc_tta-style-brook-01 vc_tta-shape-rounded vc_tta-o-shape-group invisible-tabs vc_tta-tabs-position-top vc_tta-controls-align-left invisible-tabs">
-                                <p>
+                     <div class="vc_tta-tabs-container">
-                                    With rich modal and notification functionality and a robust suite of options, Stack makes building feature-heavy pages simple and enjoyable.
+                     <ul class="vc_tta-tabs-list">
-                                </p>
+                      <li class="vc_tta-tab vc_active" data-vc-tab="">
-                            </div>
+                       <a data-vc-container=".vc_tta" data-vc-tabs="" href="#1571699207948-3199bd46-be611571699245232">
+                         <span class="vc_tta-title-text">
+                         Disease
+                        </span>
+                       </a>
+                      </li>
+                      <li class="vc_tta-tab" data-vc-tab="">
+                       <a data-vc-container=".vc_tta" data-vc-tabs="" href="#1571699993949-9be25d82-fb39">
+                        <span class="vc_tta-title-text">
+                         RoboSELEX
+                        </span>
+                       </a>
+                      </li>
+                      <li class="vc_tta-tab" data-vc-tab="">
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+                        <span class="vc_tta-title-text">
+                         Characterization
+                        </span>
+                       </a>
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+                      <li class="vc_tta-tab" data-vc-tab="">
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+                         folding
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+                        <span class="vc_tta-title-text">
+                         HP
+                        </span>
+                       </a>
+                      </li>
+                      <li class="vc_tta-tab" data-vc-tab="">
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+                        <span class="vc_tta-title-text">
+                         The sensors
+                        </span>
+                       </a>
+                      </li>
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+                       <div class="vc_tta-panel-heading">
+                        <h4 class="vc_tta-panel-title">
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+                          <span class="vc_tta-title-text">
+                           Disease
+                          </span>
+                         </a>
+                        </h4>
+                       </div>
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+                        <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae539753e1d">
+                         <h5 class="heading" style="">
+                          Disease selection &amp; marker expression
+                         </h5>
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-                            <div class="feature">
-                                <h4>Ingenuity</h4>
-                                <p>
-                                    Drastically reduce the time it takes to move from initial concept to production-ready with Stack and Variant Page Builder. Your clients will love you for it!
-                                </p>
-                            </div>
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-                         <div class="col-md-4">
+                         <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae5397541fd">
-                            <div class="feature">
+                         <div class="heading" style="">
-                                <h4>Innovation</h4>
+                          The starting point of the development cycle of the new sensor. This step entailed the selection of the target disease (cholera), the study of its pathogenic agent, the choice of its protein marker and, finally, the expression of this marker in another lab bacteria (E.coli), completely safe thanks to our negative gram membrane display system.
-                                <p>
+                          <p>
-                                    Our customers love the comfort that comes with six-months free support. Our dedicated support forum makes interacting with us hassle-free and efficient.
+                           After this, this synthetic biological platform (named Escherichia cholira in our proof of concept) went on to the next step: the RoboSELEX.
-                                </p>
+                          </p>
-                            </div>
+                          <p>
+                           Keep going to learn more about the building of this platform!
+                          </p>
+                         </div>
                          </div>
+                        <div class="tm-spacer" id="tm-spacer-5dae5397544d9">
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+                        <div class="tm-box-icon image_boxed style-01 tm-animation move-up" id="tm-box-icon-5dae5397545cc">
+                         <a class="link-secret" href="https://2019.igem.org/Team:MADRID_UCM/Synbio" target="_blank">
+                          <div class="content-wrap">
+                           <div class="image">
+                            <img alt="logo_linea_negro" src="/wiki/images/a/af/T--MADRID_UCM--wp-content~uploads~2019~10~logo_linea_negro-1.png"/>
+                           </div>
+                           <div class="content">
+                            <h4 class="heading">
+                             SynBio
+                            </h4>
+                           </div>
+                          </div>
+                         </a>
+                        </div>
+                       </div>
+                      </div>
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+                          <span class="vc_tta-title-text">
+                           RoboSELEX
+                          </span>
+                         </a>
+                        </h4>
+                       </div>
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+                         <h5 class="heading" style="">
+                          RoboSELEX
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+                          The second step of the process and central part of our technology. In this stage, we developed the molecules that support the detection of the specific pathogenic agents: aptamers.
+                          <p>
+                           Our goal for this year has been the automation of the whole aptamer-selection process (or SELEX) in order to both increase its reproducibility and facilitate the scaling of the pathogenic agents that it is able to detect.
+                          </p>
+                          <p>
+                           In our vision “Robots making aptamers” we imagine a room full of pipetting robots working full-time constantly discovering new aptamers, so we can scale up our detection system and sense more and more diseases.
+                          </p>
+                          <p>
+                           Dive into this part of the project under the RoboSELEX section in “Our Technology”!
+                          </p>
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+                        </div>
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+                         <a class="link-secret" href="http://2019.igem.org/Team:MADRID_UCM/roboselex.html" target="_blank">
+                          <div class="content-wrap">
+                           <div class="image">
+                            <img alt="logo_linea_negro" src="/wiki/images/a/af/T--MADRID_UCM--wp-content~uploads~2019~10~logo_linea_negro-1.png"/>
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+                           <div class="content">
+                            <h4 class="heading">
+                             RoboSELEX
+                            </h4>
+                           </div>
+                          </div>
+                         </a>
+                        </div>
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+                           Characterization
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+                         </a>
+                        </h4>
+                       </div>
+                       <div class="vc_tta-panel-body">
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+                         <h5 class="heading" style="">
+                          Characterization
+                         </h5>
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+                        <div class="tm-spacer" id="tm-spacer-5dae539755e31">
+                        </div>
+                        <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae539755ee4">
+                         <div class="heading" style="">
+                          Immediately after the end of the SELEX process, a series of aptamers was generated. We knew that they were specific to our protein, but how could we discover to what extent?
+                          <p>
+                           To dig into the qualities of the aptamers and obtain necessary variables such as the affinity constant, we developed several automatic characterization protocols.
+                          </p>
+                          <p>
+                           Discover how we did this under the “Aptamer Characterization” section.
+                          </p>
+                         </div>
+                        </div>
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+                         <a class="link-secret" href="http://2019.igem.org/Team:MADRID_UCM/Aptamer_Characterization" target="_blank">
+                          <div class="content-wrap">
+                           <div class="image">
+                            <img alt="logo_linea_negro" src="/wiki/images/a/af/T--MADRID_UCM--wp-content~uploads~2019~10~logo_linea_negro-1.png"/>
+                           </div>
+                           <div class="content">
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+                             Aptamer Characterization
+                            </h4>
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+                          </div>
+                         </a>
+                        </div>
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+                      </div>
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+                       <div class="vc_tta-panel-heading">
+                        <h4 class="vc_tta-panel-title">
+                         <a data-vc-accordion="" data-vc-container=".vc_tta-container" href="#1571700347312-745f907f-65f7">
+                          <span class="vc_tta-title-text">
+                           folding
+                          </span>
+                         </a>
+                        </h4>
+                       </div>
+                       <div class="vc_tta-panel-body">
+                        <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae539756743">
+                         <h5 class="heading" style="">
+D Folding &amp; Computational improvement
+                         </h5>
+                        </div>
+                        <div class="tm-spacer" id="tm-spacer-5dae539756a22">
+                        </div>
+                        <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae539756ace">
+                         <div class="heading" style="">
+                          Understanding the three-dimensional structure of aptamers is key for understanding the mechanisms that underlie their working principle.
+                          <p>
+                           Determining structural characteristics as the region where an aptamer and its ligand match can help us to direct further improvements in the most accurate way. This simplifies the SELEX process, as it stops being random, and improves efficacy.
+                          </p>
+                          <p>
+                           In the course of this year, we took a number of folding algorithms from previous teams and rewrote the folding process. We did this by applying cutting-edge AI techniques for algorithm development, which created a faster and more efficient folding.
+                          </p>
+                          <p>
+                           Do you want to know more about this process? Have a look at the “Aptamer Folding” section!
+                          </p>
+                         </div>
+                        </div>
+                        <div class="tm-spacer" id="tm-spacer-5dae539756d89">
+                        </div>
+                        <div class="tm-box-icon image_boxed style-01 tm-animation move-up" id="tm-box-icon-5dae539756e1a">
+                         <a class="link-secret" href="https://2019.igem.org/Team:MADRID_UCM/aptamer-folding.html" target="_blank">
+                          <div class="content-wrap">
+                           <div class="image">
+                            <img alt="logo_linea_negro" src="/wiki/images/a/af/T--MADRID_UCM--wp-content~uploads~2019~10~logo_linea_negro-1.png"/>
+                           </div>
+                           <div class="content">
+                            <h4 class="heading">
+D Folding &amp; Computational improvement
+                            </h4>
+                           </div>
+                          </div>
+                         </a>
+                        </div>
+                       </div>
+                      </div>
+                      <div class="vc_tta-panel" data-vc-content=".vc_tta-panel-body" id="1571700476920-efcbabe2-8bab">
+                       <div class="vc_tta-panel-heading">
+                        <h4 class="vc_tta-panel-title">
+                         <a data-vc-accordion="" data-vc-container=".vc_tta-container" href="#1571700476920-efcbabe2-8bab">
+                          <span class="vc_tta-title-text">
+                           HP
+                          </span>
+                         </a>
+                        </h4>
+                       </div>
+                       <div class="vc_tta-panel-body">
+                        <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae539757367">
+                         <h5 class="heading" style="">
+                          Sensor design &amp; implementation
+                         </h5>
+                        </div>
+                        <div class="tm-spacer" id="tm-spacer-5dae53975763f">
+                        </div>
+                        <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae5397576ed">
+                         <div class="heading" style="">
+                          An aptamer is only a molecule. To develop the best hardware that can embrace the aptamer and raise it to its maximum potential, we have carried out a series of activities aimed at better understanding the needs of the population at hand and including them in the development of the sensor.
+                          <p>
+                           In this way, the development of the sensor has been intimately linked with our Human Practices, making this entanglement one of the main features of our project. We have based our work on the tangible effect it has on real human lives, by ensuring an interdisciplinary approach that accounts for all aspects of the subject at hand.
+                          </p>
+                          <p>
+                           To this end, we made our fieldwork in Yaoundé, Cameroon a central part of the project; there, we worked together with local scientists and health workers to tackle the problem of cholera directly, rather than just withdrawing to the lab.
+                          </p>
+                          <p>
+                           We believe it is essential to not limit science to Western hegemonic knowledge, which recreates colonial patterns of thought, and this community-based fieldwork has allowed us to situate our work amidst - not against - local forms of knowledge. As such, those affected by cholera are just as much part of the project as we are, and will in the future be able to use our protocols in an independent, self-sufficient way.
+                          </p>
+                         </div>
+                        </div>
+                        <div class="tm-spacer" id="tm-spacer-5dae5397579cc">
+                        </div>
+                        <div class="tm-box-icon image_boxed style-01 tm-animation move-up" id="tm-box-icon-5dae539757a37">
+                         <a class="link-secret" href="https://2019.igem.org/Team:MADRID_UCM/Human_Practices" target="_blank">
+                          <div class="content-wrap">
+                           <div class="image">
+                            <img alt="logo_linea_negro" src="/wiki/images/a/af/T--MADRID_UCM--wp-content~uploads~2019~10~logo_linea_negro-1.png"/>
+                           </div>
+                           <div class="content">
+                            <h4 class="heading">
+                             AptaSensors
+                            </h4>
+                           </div>
+                          </div>
+                         </a>
+                        </div>
+                       </div>
+                      </div>
+                      <div class="vc_tta-panel" data-vc-content=".vc_tta-panel-body" id="1571700685704-b987c234-c36b">
+                       <div class="vc_tta-panel-heading">
+                        <h4 class="vc_tta-panel-title">
+                         <a data-vc-accordion="" data-vc-container=".vc_tta-container" href="#1571700685704-b987c234-c36b">
+                          <span class="vc_tta-title-text">
+                           The sensors
+                          </span>
+                         </a>
+                        </h4>
+                       </div>
+                       <div class="vc_tta-panel-body">
+                        <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae539757fb2">
+                         <h5 class="heading" style="">
+                          The sensors
+                         </h5>
+                        </div>
+                        <div class="tm-spacer" id="tm-spacer-5dae5397582b6">
+                        </div>
+                        <div class="tm-heading left tm-animation move-up" id="tm-heading-5dae539758370">
+                         <div class="heading" style="">
+                          An aptamer is only a molecule. To develop the best hardware that can embrace the aptamer and raise it to its maximum potential, we have carried out a series of activities aimed at better understanding the needs of the population at hand and including them in the development of the sensor.
+                          <p>
+                           In this way, the development of the sensor has been intimately linked with our Human Practices, making this entanglement one of the main features of our project. We have based our work on the tangible effect it has on real human lives, by ensuring an interdisciplinary approach that accounts for all aspects of the subject at hand.
+                          </p>
+                          <p>
+                           To this end, we made our fieldwork in Yaoundé, Cameroon a central part of the project; there, we worked together with local scientists and health workers to tackle the problem of cholera directly, rather than just withdrawing to the lab.
+                          </p>
+                          <p>
+                           We believe it is essential to not limit science to Western hegemonic knowledge, which recreates colonial patterns of thought, and this community-based fieldwork has allowed us to situate our work amidst - not against - local forms of knowledge. As such, those affected by cholera are just as much part of the project as we are, and will in the future be able to use our protocols in an independent, self-sufficient way.
+                          </p>
+                         </div>
+                        </div>
+                        <div class="tm-spacer" id="tm-spacer-5dae53975863c">
+                        </div>
+                        <div class="tm-box-icon image_boxed style-01 tm-animation move-up" id="tm-box-icon-5dae5397586b1">
+                         <a class="link-secret" href="https://2019.igem.org/Team:MADRID_UCM/Aptasensors" target="_blank">
+                          <div class="content-wrap">
+                           <div class="image">
+                            <img alt="logo_linea_negro" src="/wiki/images/a/af/T--MADRID_UCM--wp-content~uploads~2019~10~logo_linea_negro-1.png"/>
+                           </div>
+                           <div class="content">
+                            <h4 class="heading">
+                             The sensors
+                            </h4>
+                           </div>
+                          </div>
+                         </a>
+                        </div>
+                       </div>
+                      </div>
+                     </div>
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