Difference between revisions of "Team:Leiden"
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<div class="TextBox">Severe burn wounds constitute a major public health problem causing <strong>300,000 casualties</strong> annually. In 42%-65% of the times, these fatalities are caused by bacterial infections. Besides this, <strong>11 million victims</strong> a year are hospitalized, of which many are left with lifelong disfiguration and disabilities.</div> | <div class="TextBox">Severe burn wounds constitute a major public health problem causing <strong>300,000 casualties</strong> annually. In 42%-65% of the times, these fatalities are caused by bacterial infections. Besides this, <strong>11 million victims</strong> a year are hospitalized, of which many are left with lifelong disfiguration and disabilities.</div> | ||
Revision as of 13:57, 18 October 2019
S.P.L.A.S.H.
Suckerin Polymer Layer to Achieve Sustainable Health
S.P.L.A.S.H.
Suckerin Polymer Layer to Achieve Sustainable Health
Our project
Lorem ipsum dolor sit amet consectetur adipisicing elit. Natus culpa iste deleniti praesentium nobis, fugiat explicabo in sed voluptas maxime voluptate sapiente possimus quia itaque ea magni a animi saepe aspernatur reiciendis, officiis sit? Officiis praesentium perspiciatis, amet voluptate odio nobis temporibus blanditiis ipsam distinctio omnis esse, ut velit vero ea magnam voluptatem sit incidunt obcaecati doloribus neque exercitationem laudantium aliquid! Nobis velit similique provident suscipit saepe voluptate aspernatur quo accusamus delectus eum esse quasi sint quae tenetur, repudiandae eligendi facilis optio, laborum fugit natus distinctio. Dolore, voluptatem delectus mollitia expedita necessitatibus, totam, sed ut voluptas nostrum quas id eligendi?
Severe burn wounds constitute a major public health problem causing 300,000 casualties annually. In 42%-65% of the times, these fatalities are caused by bacterial infections. Besides this, 11 million victims a year are hospitalized, of which many are left with lifelong disfiguration and disabilities.
Donor skin, used in current treatments, is scarce due to specific requirements and many processing steps leading to high demand for alternative treatments. Various materials have been investigated for the production of wound dressings to substitute donor skin. Even though improvements have been made in the form of hydrogels, many features are still missing. The biomaterial suckerin combines all required characteristics for a wound dressing, due to their unique properties and can be used to further optimize hydrogel treatment. Therefore, a suckerin-based hydrogel can improve the treatment of third-degree burn wounds.
Suckerin is originally found in the sucker ring teeth of the Humboldt squid Dosidicus gigas. Suckerin assets unique features such as flexibility, strength, and ability to self-assemble into β-sheets, making it ideal for hydrogel formation. As a protein, suckerin can be produced by microorganisms and opens up possibilities for molecular engineering enabling fast and high-yield production. The iGEM Leiden 2019 team thrives to use these assets to produce a suckerin-based hydrogel as a donor skin substitute.
Introducing a cleavable linker system enables the joining of antimicrobial peptides, numbing agents and wound healing stimulators. Therefore, our suckerin-based hydrogel can improve the prognosis for burn wound victims by both preventing infections and promoting wound healing.