Difference between revisions of "Team:CAU China/Description"
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| − | <p class="text-justify"> | + | <p class="text-justify"> Through this year's project, we plan to use E.coli to achieve the transition from straw to astaxanthin. </p> |
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| − | + | <p class="text-justify"> As an agricultural waste, straw is closely related to many wide-concerned topics such as environmental protection and energy saving. Our project may provide a new idea for the treatment of straw. </p> | |
| − | + | ||
| − | + | <p class="text-justify"> Currently, astaxanthin is the only carotenoid found to cross the blood-brain barrier. It is also the most powerful antioxidant, having up to 100 times more potency than other carotenoids such as β-carotene, lutein, and lycopene. Astaxanthin from natural algae is 100% l-rotatory, which has the strongest biological activity and plays an active role in improving immunity, preventing the occurrence and development of chronic diseases such as tumor, cardiovascular disease and diabetes, and delaying aging. Haematococcus Pluvialis is considered as one of the best natural astaxanthin producers, but its cultivation and preservation conditions are so complicated that only a few enterprises can master. The price of pure astaxanthin products (≥98%) in SIGMA company is as high as $200 /50mg. </p> | |
| − | + | ||
| − | + | <p class="text-justify"> As an exogenous gene expression system, E.coli has many advantages such as clear genetic background, complete carrier receptor system, rapid growth, simple culture and stable recombinant daughteris. Therefore, we decide to use E.coli as our material. </p> | |
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| − | + | <p class="text-justify"> In general, we want to build two strains of metabolically engineered Escherichia coli. One of them aims to degrade straw into glucose, the other one synthesizes astaxanthin from glucose by using the optimal combination of astaxanthin biosynthetic pathway genes. Then, these two strains will be co-cultured and are expected to produce astaxanthin with high yield and purity on the basis of low cost of raw materials, and finally realize the purpose of turning waste into treasure, which has a broad market prospect and application value. </p> | |
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Revision as of 05:46, 27 June 2019
Abstract
Through this year's project, we plan to use E.coli to achieve the transition from straw to astaxanthin.
As an agricultural waste, straw is closely related to many wide-concerned topics such as environmental protection and energy saving. Our project may provide a new idea for the treatment of straw.
Currently, astaxanthin is the only carotenoid found to cross the blood-brain barrier. It is also the most powerful antioxidant, having up to 100 times more potency than other carotenoids such as β-carotene, lutein, and lycopene. Astaxanthin from natural algae is 100% l-rotatory, which has the strongest biological activity and plays an active role in improving immunity, preventing the occurrence and development of chronic diseases such as tumor, cardiovascular disease and diabetes, and delaying aging. Haematococcus Pluvialis is considered as one of the best natural astaxanthin producers, but its cultivation and preservation conditions are so complicated that only a few enterprises can master. The price of pure astaxanthin products (≥98%) in SIGMA company is as high as $200 /50mg.
As an exogenous gene expression system, E.coli has many advantages such as clear genetic background, complete carrier receptor system, rapid growth, simple culture and stable recombinant daughteris. Therefore, we decide to use E.coli as our material.
In general, we want to build two strains of metabolically engineered Escherichia coli. One of them aims to degrade straw into glucose, the other one synthesizes astaxanthin from glucose by using the optimal combination of astaxanthin biosynthetic pathway genes. Then, these two strains will be co-cultured and are expected to produce astaxanthin with high yield and purity on the basis of low cost of raw materials, and finally realize the purpose of turning waste into treasure, which has a broad market prospect and application value.