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| <html> | | <html> |
− | <link href="https://2019.igem.org/Template:USTC-Software/css/default?action=raw&ctype=text/css" rel="stylesheet" | + | <!--对应链接<li><a href="https://2019.igem.org/Team:USTC-Software/Public_Engagement">Engagement</a></li>--> |
− | type="text/css"/>
| + | <link href="https://2019.igem.org/Template:USTC-Software/css/default?action=raw&ctype=text/css" rel="stylesheet" |
− | <link href="https://2019.igem.org/Template:USTC-Software/css/bootstrap?action=raw&ctype=text/css" rel="stylesheet" | + | type="text/css" /> |
− | type="text/css"/>
| + | <link href="https://2019.igem.org/Template:USTC-Software/css/bootstrap?action=raw&ctype=text/css" rel="stylesheet" |
− | <script src="https://2019.igem.org/Template:USTC-Software/js/jquery?action=raw&ctype=text/javascript" | + | type="text/css" /> |
− | type="text/javascript"></script>
| + | <script src="https://2019.igem.org/Template:USTC-Software/js/jquery?action=raw&ctype=text/javascript" |
− | <script src="https://2019.igem.org/Template:USTC-Software/js/popper?action=raw&ctype=text/javascript" | + | type="text/javascript"></script> |
− | type="text/javascript"></script>
| + | <script src="https://2019.igem.org/Template:USTC-Software/js/popper?action=raw&ctype=text/javascript" |
− | <script src="https://2019.igem.org/Template:USTC-Software/js/bootstrap?action=raw&ctype=text/javascript" | + | type="text/javascript"></script> |
− | type="text/javascript"></script>
| + | <script src="https://2019.igem.org/Template:USTC-Software/js/bootstrap?action=raw&ctype=text/javascript" |
− | <div class="container">
| + | type="text/javascript"></script> |
− | <div class="row">
| + | |
− | <div class="col-lg-3 col-md-0">
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− | <div class="autoMenu d-none d-lg-block" data-autoMenu id="autoMenu"></div>
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− | </div>
| + | |
− | <div class="col-lg-9 col-md-12">
| + | |
− | <div class="card page-content">
| + | |
− | <div class="card-body">
| + | |
− | <h1 class="text-center">Human Practice</h1>
| + | |
− | <h3>Earlier Stage</h3>
| + | |
− | <h4>Visit to Huaheng Biotech</h4>
| + | |
− | <div class="passage">Huaheng Biotech is a company which the leading position around the world, in the field of
| + | |
− | alanine products producing using methods of microbiological fermentation. They had put a major capital
| + | |
− | investment in research and development. After communicating with their research leader, we took a visit to
| + | |
− | their plant and had a meetup with their researchers. <br>
| + | |
− | <div class="text-center psgImg">
| + | |
− | <img src="https://static.igem.org/mediawiki/2019/e/e0/T--USTC-Software--hp1.jpg" alt="">
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− | </div>
| + | |
− | Despite their high level of research, they said that there remained no good pre-analytical way to decide how
| + | |
− | to improve their process of production. The existing way and tools had too many limits to be used by
| + | |
− | researchers so that they could only experiment with changes thought out of experience. Also, with careful
| + | |
− | consideration of environmental protection, they kept on finding ways to improve their products while not
| + | |
− | impact productive rates. <br>
| + | |
| | | |
− | </div>
| + | <div id="autoMenu2" class="autoMenu2"></div> |
− | <h4>Meeting with Prof. Jiong Hong</h4>
| + | <div class="container"> |
− | <div class="passage">
| + | <div class="row"> |
− | After acknowledging the problems faced in the real world, we went to have a meeting with our PI, professor
| + | <!-- <div class="col-lg-2 col-md-0">--> |
− | Jiong Hong. Prof. Hong informed us about the existence of Flux Balance Analysis and further researches based
| + | <!-- <div class="autoMenu d-none d-lg-block" data-autoMenu id="autoMenu"></div>--> |
− | on it. Then we had some investigation about FBA, only to find that all existing tools to do FBA lack the
| + | <!-- </div>--> |
− | ease of use despite the beauty of its method. It first came into our mind to build a great FBA tool that
| + | <div class="col-lg-12 col-md-12"> |
− | meets the requirements of real production environments.
| + | <div class="card page-content" style="background: rgba(255, 255, 255, 0.6);"> |
− | <br>
| + | <div class="card-body"> |
− | <div class="text-center psgImg"> | + | <h1 class="text-center">Public Engagement And Education</h1> |
− | <img src="https://static.igem.org/mediawiki/2019/3/36/T--USTC-Software--hp_hongjiong.jpg" alt="">
| + | <h3>Overview</h3> |
| + | <div class="passage"> |
| + | To include more people in participating in work in synthetic biology and promote both iGEM and us in the |
| + | local community, |
| + | we made efforts in education, propaganda, and a board game. |
| </div> | | </div> |
− | </div>
| + | <h3>Public Engagement</h3> |
− | <h4>Preliminary product design</h4>
| + | <h4>USTC-interesting Synthetic Transaction and Cooperation</h4> |
− | <div class="passage">
| + | <div class="passage"> |
− | We proposed a revolutionary workflow that would greatly improve efficiency and decrease the complexity of
| + | In order to promote public awareness of synthetic biology and introduce its basic ideas to the laymen, |
− | using. In other words, we designed a high-level framework to automatically solve many inner logics and thus
| + | our team is devoted to the development of a board game which aims at instructing non-biologists to |
− | simplify the process of analysis.
| + | understand |
− | <br>
| + | what biobricks can do and how can we use them to make new things. |
− | <div class="text-center psgImg">
| + | <br><br> |
− | <img src="https://static.igem.org/mediawiki/2019/b/b2/T--USTC-Software--downside1.png" alt="">
| + | As games have become a significant part of our spare time, and most youngsters would rather play games to |
| + | have fun. |
| + | We consider it a perfect opportunity to introduce synthetic biology to them. |
| + | <br><br> |
| + | To attract more people without such background to be interested in this area, we develop this board game |
| + | specially |
| + | designed for synthetic biology. In this game, even laymen can have fun. We greatly weakened the hardcore |
| + | and |
| + | annoying part of synthetic biology when we keep the main idea of it. |
| + | <div class="psgImg"> |
| + | <img src="https://static.igem.org/mediawiki/2019/c/ca/T--USTC-Software--public_card_game.jpg" alt=""> |
| + | <p>Card Game</p> |
| + | </div> |
| + | <br> |
| + | Still want to know more? <a href="https://static.igem.org/mediawiki/2019/d/dc/T--USTC-Software--game_instruction.pdf">Click Here</a>. |
| + | </div> |
| + | <h4>USTC1958 Café</h4> |
| + | <div class="passage"> |
| + | In our broader community, there's a café called USTC1958, which is the highest rating café in Hefei, |
| + | according to the internet. We consider it a great way to interact with them. They may add color to our |
| + | project while we can add new elements for them. |
| + | <br><br> |
| + | <div class="psgImg"> |
| + | <img src="https://static.igem.org/mediawiki/2019/6/6b/T--USTC-Software--public_cafe0.jpg" alt=""> |
| + | <p>USTC1958 Cafe</p> |
| + | </div> |
| + | Talking with the café owner, she spoke highly of our projects and enthusiasm, and also showed great |
| + | interest in |
| + | synthetic biology. As an attractive café owner, she provided brilliant suggestions for our team name, |
| + | logo, and |
| + | uniform. Since we don't have a teammate in the art relating majors, their advice had a great influence on |
| + | us. |
| + | <br><br> |
| + | Meanwhile, we gave an overview of synthetic biology to them. They were interested in it and willing to add |
| + | some |
| + | "synthetic" elements in the café. We offered to rendered our board game, which may help the customer kill |
| + | time |
| + | and subtly teach them some aspects of synthetic biology. Thus we can make complex scientific information |
| + | flow into the community. |
| + | <br><br> |
| + | <div class="psgImg"> |
| + | <img src="https://static.igem.org/mediawiki/2019/2/2d/T--USTC-Software--public_cafe.png" alt=""> |
| + | <p>Having a chat in the cafe</p> |
| + | </div> |
| + | It's really marvelous that more and more people will start learning with games and coffee. |
| </div> | | </div> |
− | <br>
| |
− | <div class="text-center psgImg">
| |
| | | |
− | <img src="https://static.igem.org/mediawiki/2019/4/49/T--USTC-Software--downside2.png" alt=""> | + | <h3>Education</h3> |
| + | <h4>Video for kids</h4> |
| + | <div class="passage"> |
| + | At the very beginning of our project, we came up with an idea of making a promotional video for the |
| + | children and teenagers. |
| + | Considering they may not know much about synthetic biology or even biology, we made our video |
| + | uncomplicated and cute, |
| + | only want to encourage them to step in and explore by themselves. We believe it's the best way to appeal |
| + | to an amateur. |
| + | <br><br> |
| + | <div class="psgImg"> |
| + | <video width="760" height="480" controls="" __idm_id__="787084289"> |
| + | <source src="https://static.igem.org/mediawiki/2019/f/ff/T--USTC-Software--educational_video.mp4" type="video/mp4"> |
| + | </video> |
| + | </div> |
| + | <br><br> |
| + | Teenagers, especially kids, love cartoons. Through our fascinating video, the children not only gained |
| + | happiness but |
| + | also increased their biological knowledge. |
| + | We contacted the Bureau of Education of Yongji County, Jilin City, Jilin Province, hoping that we could |
| + | play our |
| + | video in a primary school. They are pleased with our idea and speak highly of our popular science work. |
| + | Then our video was permitted to be played in all of the schools there. The influence was beyond our |
| + | expectation, |
| + | and the pupils and junior students were indeed stimulated by the marvel world of synthetic biology. |
| + | <br><br> |
| + | <div class="psgImg"> |
| + | <img src="https://static.igem.org/mediawiki/2019/5/51/T--USTC-Software--public_lesson2.jpg" alt=""> |
| + | <p>Land on class</p> |
| + | </div> |
| + | <div class="psgImg"> |
| + | <img src="https://static.igem.org/mediawiki/2019/b/b0/T--USTC-Software--public_video1.jpg" alt=""> |
| + | <p>Concentrating in the class</p> |
| + | </div> |
| + | How do we say that? The teachers there mailed us, retelling several questions; for example, in the first |
| + | edition of our video, |
| + | we simply implant the "Fragrant Gene" and complete the workflow, which is inaccurate. Some students were |
| + | confused if that's |
| + | all we need to perform synthesis. We then replied, answering the question, and modified our video. We |
| + | regard such positive |
| + | feedback as our success in the effort of education towards the youngers. |
| + | <br> |
| + | <div class="psgImg"> |
| + | <img src="https://static.igem.org/mediawiki/2019/1/19/T--USTC-Software--public_video2.jpg" alt=""> |
| + | <p>Watching the iGEM videos</p> |
| + | </div> |
| + | <br> |
| + | <div class="psgImg"> |
| + | <img src="https://static.igem.org/mediawiki/2019/2/25/T--USTC-Software--public_video3.jpg" alt="" style="max-height: 700px"> |
| + | <p>Propaganda biology</p> |
| + | </div> |
| </div> | | </div> |
− | We first considered to support a wild and customized searching function based on the optimization of | + | <h4>Lecture for teenagers</h4> |
− | databases. After a job done by UESTC-Software in 2018, we wanted to do some upgrade of the scale of
| + | <div class="passage"> |
− | databases.
| + | Besides this, we also planned to promote synthetic biology to high school students. |
− | <br>
| + | For sure, the video we made seems too simple to them, so we decided to present them a lecture, namely, a |
− | Then we visited Wenfei Yu, the leader of team USTC in 2018, and got acknowledged about some common databases
| + | lesson. |
− | used in Syn-Biology and their shortcomings. Also, we became aware of cobrapy, a tool that offers several
| + | Back to his alma mater, our biology team leader Suyang Zhong gave his junior students a speech about |
− | APIs to do FBA.
| + | biology and synthetic biology. |
− | <br>
| + | <br><br> |
− | To help us, USTC 2019 team gave us a hand, which enabled us to be instantly familiar with cobra. <br>
| + | <div class="psgImg"> |
− | <div class="text-center psgImg">
| + | <img src="https://static.igem.org/mediawiki/2019/5/51/T--USTC-Software--public_lesson2.jpg" alt=""> |
− | <img src="https://static.igem.org/mediawiki/2019/3/34/T--USTC-Software--hp_cobra.jpg" alt="">
| + | <p>Land on class</p> |
| + | </div> |
| + | According to the biology teacher, current students prefer to spend more time studying math or physics. |
| + | Though they are indeed the basis of biology, |
| + | it's also true that they are more likely to choose other majors after going to college. |
| + | <br><br> |
| + | In the lecture, we first introduced the fantastic biology world. Then we elaborated on what is synthetic |
| + | biology about and what is iGEM Foundation. |
| + | Of course, we propaganda our team and our project. They listened carefully, seemed that we had Ignited |
| + | their passion for biology. And we sincerely |
| + | hope these potential students can join us, becoming the future generation of iGEMers. |
| + | <div class="psgImg"> |
| + | <img src="https://static.igem.org/mediawiki/2019/d/d6/T--USTC-Software--public_meeting.jpg" alt=""> |
| + | <p>Lesson</p> |
| + | </div> |
| </div> | | </div> |
− | </div>
| + | <h4>Meeting</h4> |
− | <h3>Mid-term: A Change of Emphasis</h3>
| + | <div class="passage"> |
− | <h4>Meetup with SYSU 2019 team</h4>
| + | Our university has made significant achievements in physics and math, and we have plenty of undergraduates |
− | <div class="passage">
| + | majoring in them. However, |
− | We went to Guangzhou in July and visited the iGEM team of Sun Yat-sen University. In the meetup, we
| + | we found our mates knew little about synthetic biology and iGEM. Therefore, Team USTC and we held a |
− | introduced our projects to each other. At that time, we devoted ourselves to optimize our database which was
| + | meeting in our university to |
− | at a great scale and then linking the output to FBA’s input. However, our idea hadn’t been fully approved by
| + | popularize synthetic biology and present our projects to the entire school, trying to absorb new force. |
− | the SYSU team and their professor. They put forward that out idea about optimizing massive databases was not
| + | <br><br> |
− | targeted for Synthetic Biology. In other words, there was a bias in our aim, for the work done to optimize
| + | |
− | the databases will distract us to design FBA workflow and its efficiency.
| + | |
− | <br>
| + | |
− | In the emergency meeting that night we all admitted that the problem did exist. Then we decided immediately
| + | |
− | a change of emphasis of our project, which would more concentrated on the optimization of FBA and the whole
| + | |
− | framework.
| + | |
| | | |
− | </div>
| + | <div class="psgImg"> |
− | <h4>Discussion with upperclassmen</h4>
| + | <img src="https://static.igem.org/mediawiki/2019/6/6e/T--USTC-Software--public_lesson.jpg" alt=""> |
− | <div class="passage">
| + | <p>Meeting</p> |
− | He helped us tease out our whole project and his clear thinking impressed us very much. He then raised a
| + | </div> |
− | question that whether we can provide a recommendation of Biobricks when we end up giving graphs of analysis.
| + | In our meeting room, students, namely, our potential iGEMers from all kinds of majors, listened carefully. |
− | For example, if modifications and analysis had been done to the user's model based on E. coli, the
| + | We told them what is synthetic biology in detail, like how a synthetic biologist works, and what we have |
− | researcher can immediately be acknowledged by our system which Biobricks he or she can use. After more
| + | acquired during this year's project. |
− | discussion, we found it would be a pretty useful function. So we decided to append our system with a micro
| + | They are deeply fascinated by the world of synthetic biology that we described. During our Q&A time, they |
− | recommendation system for proper Biobricks. <br>
| + | asked many questions and were eager |
− | <div class="text-center psgImg">
| + | to know what do they need to join us. We were surprised by their enthusiasm, and it seems that we |
− | <img src="https://static.igem.org/mediawiki/2019/4/42/T--USTC-Software--hp_upperclassman.jpg" alt="">
| + | successfully intrigued more people participating in synthetic biology. |
| </div> | | </div> |
− | </div>
| + | <h3>Conclusion</h3> |
− | <h3>CCIC: Weighing and Cooperating</h3>
| + | <div class="passage"> |
− | <div class="passage">
| + | By presenting lectures at schools and introducing our project into the broader community, we are sure such |
− | CCic, which stands for the Conference of China iGEMer Community, is the biggest synthetic biology conference
| + | activities can help promote synthetic biology and iGEM. We interacted with many schools and successfully |
− | in China. This year we had a wonderful time there in Shenzhen. We did presentations and our idea was
| + | promoted mutual learning and engagement. We also thought seriously about the difference between elementary |
− | evaluated by many experts and lovers in the field of synthetic biology. There we were encouraged to expand
| + | students and undergraduates, using different methods to promote synthetic biology instead of using only |
− | our project to a platform, using which users can share their models, and see the history of modifying. It
| + | one type of propaganda. Meanwhile, we made some efforts to collaborate with our broader community. We |
− | enriched our project, made it closer to a mature one.
| + | talked with a popular café and introduced our project. Then we designed a syn-bio relating board game and |
− | <br>
| + | rendered them for their customers. No one can say no to coffee and games, and so do someone may love |
− | <div class="psgImg text-center">
| + | biology. We're sure such activities can enable more people to contribute and participate in synthetic |
− | <img src="https://static.igem.org/mediawiki/2019/8/8a/T--USTC-Software--hp_meetinccic.jpg" alt=""> | + | biology. Our works are bitter like coffee, but the rewards are pleasant like board games. |
| </div> | | </div> |
− | </div>
| |
− | <h4>Communication with Tongji 2019</h4>
| |
− | <div class="passage">
| |
− | After our presentation, teammates of Tongji 2019 found us and asked whether we can offer some more specific
| |
− | suggestions, for their project was related to increasing generation rate of products of fermentation.
| |
− | After knowing that we can only analyze changes of major metabolites’ flux, they were quite disappointed. We
| |
− | talked to the professors and some senior students there at CCIC and they approved our design. For "it is not
| |
− | unnecessary for a researcher who does flux analysis to do this job, for it should be considered during
| |
− | experimental design. Your analysis of flux major metabolites is much more useful in a generative perspective
| |
− | and considering the accuracy."
| |
− | </div>
| |
− | <h4>Cooperating with UESTC-Software</h4>
| |
− | <div class="passage">
| |
− | During the communication with UESTC-Software 2019, we came up with the idea to build our recommendation
| |
− | system base on their well-handled data, for they had done a great job in collecting data and optimizing
| |
− | databases. We then reached cooperation with each other and the first time opened up collaboration lying
| |
− | deeply in the projects of iGEM Software Teams.
| |
− | </div>
| |
− | <h3>The Test Run</h3>
| |
− | <h4>With USTC 2019</h4>
| |
− | <div class="passage">
| |
− | Team USTC has always been enthusiastic to help us test our tool and improve our project. We had done several
| |
− | tests together, during which some small functions, such as optimizations with the display of graphs in the
| |
− | output, comparisions between different but alike models and polishing UI of the interface, were added in.
| |
− | </div>
| |
− | <h4>With SJTU-Software 2019</h4>
| |
− | <div class="passage">
| |
− | unfinished yet
| |
− | </div>
| |
− | <h2 class="ref">References</h2>
| |
− | <div class="ref-list">
| |
− | <ul>
| |
− | <li>1. https://www.ncbi.nlm.nih.gov</li>
| |
− | <li>2. https://2018.igem.org/Team:UESTC-Software/Description</li>
| |
− | </ul>
| |
| </div> | | </div> |
| </div> | | </div> |
| </div> | | </div> |
| </div> | | </div> |
− | </div>
| |
| | | |
| | | |
− | </div> | + | </div> |
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