Team:UniGE-Geneva/Team

Unige iGEM 2019

Inspiration

The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.

Project

We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.

Content

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Team

In this page you can introduce your team members, instructors, and advisors.

What should this page contain?

  • Include pictures of your teammates, don’t forget instructors and advisors!
  • You can add a small biography or a few words from each team member, to tell us what you like, and what motivated you to participate in iGEM.
  • Take team pictures! Show us your school, your lab and little bit of your city.
  • Remember that image galleries can help you showcase many pictures while saving space.

Inspiration

You can look at what other teams did to get some inspiration!
Here are a few examples: