Team:UniGE-Geneva/Part Collection

Unige iGEM 2019

Inspiration

The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.

Project

We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.

Content

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Part Collection

Did your team make a lot of great parts? Is there a theme that ties all your parts together? Do you have more than 10 parts in this collection? Did you make a CRISPR collection, a MoClo collection, or a collection of awesome pigment parts? Describe your parts collection on this page, so the judges can evaluate you for the Best Part Collection award.

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Note

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Best Part Collection Special Prize

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