Team:UniGE-Geneva/Measurement
Inspiration
The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.
Project
We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.
Content
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Measurement
There are a lot of exciting parts in the Registry, but many parts have still not been characterized or need more characterization to make them more useful. Synthetic Biology needs great measurement approaches for characterizing parts, and efficient new methods for characterizing many parts at once. If you've done something exciting in the area of Measurement, describe it here!
Best Measurement Special Prize
If you've done excellent work in measurement, you should consider nominating your team for this special prize. Designing great measurement approaches for characterizing new or existing parts or developing and implementing an efficient new method for characterizing thousands of parts are good examples.
To compete for the Best Measurement prize, please describe your work on this page and also fill out the description on the judging form.
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Inspiration
You can look at what other teams did to get some inspiration!
Here are a few examples: