Team:UniGE-Geneva/Improve
Inspiration
The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.
Project
We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.
Content
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Improve a Previous Part or Previous Project
For teams seeking to improve upon a previous part or project, you should document all of your work on this page. Please remember to include all part measurement and characterization data on the part's main page on the Registry. Please include a link to your improved part's Registry page on this page.
Gold Medal Criterion #2
Improve a Previous Part - Standard Tracks: Convince the judges that you have created a new BioBrick Part that has a functional improvement upon an existing BioBrick Part. You must perform experiments with both parts to demonstrate this improvement. Clearly document the quantitative experimental characterization data on the Part's Main Page on the Registry for both the existing and new parts (see the Registry Document Parts page for instructions).
Both the existing and new part must be RFC10 or Type IIS compatible. The sequences of the new and existing parts must be different. The existing part must NOT be from your 2019 part number range and must be different from the part you used in Bronze #4. The new part you create must also be different from the new part documented in Silver #1. Please see the Measurement Resources page for more information about experimental characterization data.
Improve a Previous Project - Special Tracks: Improve the function of an existing iGEM project (that your current team did not originally create) and display your achievement on your wiki.