Team:UniGE-Geneva/Hardware
Inspiration
The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.
Project
We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.
Content
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Hardware
Best Hardware Special Prize
In addition to encouraging teams to work with DNA parts and build biological devices in the lab, iGEM also encourages other types of technical solutions for synthetic biology. This can include physical devices (hardware) related to robotic assembly, microfluidics, low-cost measurement devices, to name a few examples. There are many exciting opportunities for hardware innovation in synthetic biology.
Teams who are interested in working with hardware in their project, or as a side project, are encouraged to apply for the Best Hardware award.
To compete for the Best Hardware prize, please describe your work on this page and also fill out the description on the judging form.
You must also delete the message box on the top of this page to be eligible for this prize.
Inspiration
You can look at what other teams did to get some inspiration!
Here are a few examples: