Team:UniGE-Geneva/Contribution


Unige iGEM 2019

Inspiration

The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.

Project

We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.

Content

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Characterization or Contribution

Bronze Medal Criterion #5

Characterization - Standard Tracks: Convince the judges that you have added quantitative experimental characterization data to an existing Part from the Registry of Standard Biological Parts. Clearly document the experimental characterization on the Part's Main Page on the Registry (see the Registry Document Parts page for instructions). The part that you are characterizing must NOT be from a 2019 part number range. It is acceptable to add new data to an already highly characterized part. Please see the Measurement Resources page for more information about experimental characterization data. Sample submission is not required.

You should list the part(s) you characterized for this medal criterion on this page and include links to the part's Registry pages, but all data must be added to the Part's Main Page on the Registry.

Contribution - Special Tracks: Document on your team wiki at least one new substantial contribution to the iGEM community that showcases a project related to BioBricks. This contribution should be central to your project and equivalent in difficulty to characterizing a BioBrick Part.