Team:UniGE-Geneva/Composite Part
Inspiration
The replacement of animal testing by alternative in vitro methods is now being encouraged by the World Health Organization and the US Food and Drug Administration (FDA). However, replacing animal models is a big challenge for laboratories because current in vitro cell cultures poorly reflect the physiological organization of tissues. This has led to low success rates for drugs because a high proportion (~98%) of those that appear efficacious in vitro do not succeed during in vivo trials. Therefore, we believe there is an urgent need to improve in vitro drug testing to better simulate the in vivo physiology of animal models.
Project
We would like to create a drug-testing toolbox that is capable of measuring the effects of multiple interdependent biological activities with physiological relevance. By mimicking physiological conditions that occur in vivo, our goal is to improve in vitro drug testing to reduce the reliance on animal experimentation, as well as increase the efficiency and accuracy of drug screening. For this aim, we will use novel cell co-culture formats, including cancer and hepatocyte cell lines. Importantly, our co-culture formats aim to improve upon several aspects of existing spheroid cultures.
Content
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★ ALERT!
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Composite Parts
A composite part is a functional unit of DNA consisting of two or more basic parts assembled together. BBa_I13507 is an example of a composite part, consisting of an RBS, a protein coding region for a red fluorescent protein, and a terminator.
New composite BioBrick devices can be made by combining existing BioBrick Parts (like Inverters, Amplifiers, Smell Generators, Protein Balloon Generators, Senders, Receivers, Actuators, and so on).
Note
This page should list all the composite parts your team has made during your project and include direct links to your Parts main pages on the Registry. You must add all characterization information for your parts on Parts Main Page on the Registry. You should not put characterization information on this page. Remember judges will only look at the first part in the list for the Best Composite Part award, so put your best part first!
Best Composite Part Special Prize
To be eligible for this award, this part must be well documented on the part's Main Page on the Registry. If you have a part you wish to nominate your team for this special prize, make sure you add your part number to your judging form and delete the alert box at the top of this page.
Please note: Judges will only look at the first part number you list, so please only enter ONE (1) part number in the judging form for this prize.